The novel resveratrol analogue HS-1793 induces apoptosis via the mitochondrial pathway in murine breast cancer cells

Kim, Hyoun-Ji; Yang, Kwangmo; Park, Yoo-Soo; Choi, Yoo-Jin; Yun, JiHyeon; Son, Cheol; Suh, Hongsuk; Jeong, Min-Ho; Jo, Wol-Soon

doi:10.3892/ijo.2012.1615

Cited by 25 publications

(21 citation statements)

References 35 publications

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“…The absence of apoptosis‐inducing effect of RVT in ESCs is also distinguished from findings reported in cancer cells . Regarding the mechanism, RVT exerts its apoptosis‐inducing effects by inhibiting various survival pathways such as PI3‐kinase and STAT3 and suppressing the expression of anti‐apoptotic molecules such as survivin, bcl‐2, and bcl‐x .…”

Section: Discussionmentioning

confidence: 76%

Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells

Taguchi

Koga

Kawana

et al. 2016

American J Rep Immunol

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Section: Discussionmentioning

confidence: 76%

Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells

Taguchi

Koga

Kawana

et al. 2016

American J Rep Immunol

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“…The agents (Fas L) connected with Fas (CD95) then trigger the extrinsic pathway followed by the activation of caspase-8 and then activation of effector caspase-3 to cause cell apoptosis (23). Thus, we hypothesized that the extrinsic apoptotic pathway in NCI-H460 cells was activated following exposure to DMC.…”

Section: Discussionmentioning

confidence: 99%

Demethoxycurcumin induces the apoptosis of human lung cancer NCI-H460 cells through the mitochondrial-dependent pathway

Lien

Liu

et al. 2015

Oncology Reports

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Abstract. Lung cancer is the most common cause of cancerrelated mortality in the US as well as other regions of the world. Curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) are the major components of Curcuma longa L. It has been reported that curcumin inhibits the growth of various types of cancer cells in vitro and in vivo. However, the mechanisms involved in the inhibition of cell growth and induced apoptosis by DMC in human lung cancer cells remain unclear. In the present study, we investigated the effect of DMC on cell death via the induction of apoptosis in NCI-H460 human lung cancer cells. Flow cytometric assay was used to examine the total percentage of viable cells, the population of cells in the sub-G1 phase of the cell cycle, the level of reactive oxygen species (ROS), Ca 2+ production, mitochondrial membrane potential (ΔΨm) and caspase activity. Western blotting was used to examine the changes in the expression of cell cycle-and apoptosis-associated proteins. Confocal microscopy was used to examine the translocation of apoptosis-associated proteins. The results indicated that DMC significantly induced cell morphological changes and decreased the percentage of viable NCI-H460 cells and DMC induced apoptosis based on the cell distribution in the sub-G1 phase. Moreover, DMC promoted ROS and Ca 2+ production and decreased the level of ΔΨm and promoted the activities of caspase-3, -8 and -9. The Western blotting results showed that DMC promoted the expression of AIF, Endo G and PARP. The levels of Fas ligand (Fas L) and Fas were also upregulated. Furthermore, DMC promoted expression of ER stress-associated proteins such as GRP78, GADD153, IRE1β, ATF-6α, ATF-6β and caspase-4. Based on the findings, we suggest that DMC may be used as a novel anticancer agent for the treatment of lung cancer in the future.

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“…Major treatment strategies for breast cancer consist, either separately or in combination of, radio therapy, surgery and chemotherapy (3). Many agents used to treat breast cancer are often associated with severe systemic toxicities.…”

Section: Introductionmentioning

confidence: 99%

“…However, exposure to high doses of resveratrol is required to induce apoptosis in cancer cells. In addition, resveratrol is photosensitive and metabolically unstable, with stilbene double bonds being readily oxidized (3,10).…”

Section: Introductionmentioning

confidence: 99%

HS-1793, a resveratrol analogue, induces cell cycle arrest and apoptotic cell death in human breast cancer cells

Kim

Hossain

et al. 2013

International Journal of Oncology

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Abstract. Resveratrol, a polyphenolic compound, is a naturally occurring phytochemical and is found in a variety of plants, including food such as grapes, berries and peanuts. It has gained much attention for its potential anticancer activity against various types of human cancer. However, the usefulness of resveratrol as a chemotherapeutic agent is limited by its photosensitivity and metabolic instability. In this study the effects of a synthetic analogue of resveratrol, HS-1793, on the proliferation and apoptotic cell death were investigated using MCF-7 (wild-type p53) and MDA-MB-231 (mutant p53) human breast cancer cells. HS-1793 inhibited cell growth and induced apoptotic cell death in a concentration-dependent manner. The induction of apoptosis was determined by morphological changes, cleavage of poly(ADP-ribose) polymerase, alteration of Bax/Bcl-2 expression ratio and caspase activities. Flow cytometric analysis revealed that HS-1793 induced G2/M arrest in the cell cycle progression in both types of cells. Of note, HS-1793 induced p53/p21 WAF1/CIP1 -dependent apoptosis in MCF-7 cells, whereas it exhibited p53-independent apoptosis in MDA-MB-231 cells. Furthermore, HS-1793 showed more potent anticancer effects in several aspects compared to resveratrol in MCF-7 and MDA-MB-231 cells. Thus, these findings suggest that HS-1793 has potential as a candidate chemotherapeutic agent against human breast cancer. IntroductionBreast cancer is one of the most common malignant tumors and is the leading cause of cancer-related deaths in women worldwide (1). Five-year survival rate for tumor confined to the breast has increased to ~80-90% over the last decade. However, approximately one-third of breast cancer patients still die from the disease once tumor metastasized to other organs (2).Major treatment strategies for breast cancer consist, either separately or in combination of, radio therapy, surgery and chemotherapy (3). Many agents used to treat breast cancer are often associated with severe systemic toxicities. Acquired tumor drug resistance also limits their use in the treatment of breast cancer. Therefore, novel non-toxic therapeutic agents active against breast cancer are under investigation, with the need to develop new agents acting on novel targets.Resveratrol (trans-3,4,5'-trihydroxydtilbene, Fig. 1A) is a natural polyphenol compound (4,5). It has been reported to exhibit a wide range of biological and pharmacological properties. It exists in two isoforms: trans-resveratrol and cis-resveratrol; however, the trans-isomer is more stable than cis-resveratrol. Resveratrol-glucuronide is the major form absorbed when compared to the very minute amounts of unconjugated resveratrol and resveratrol sulfate are absorbed (6). Resveratrol has been reported to induce apoptosis in various cancerous or transformed cells in culture, chemically induced mouse skin tumors, and in transplanted tumors in nude mice by activating both extrinsic and intrinsic pathways of cell death machinery (7,8). Resveratrol has shown to inhibit th...

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The novel resveratrol analogue HS-1793 induces apoptosis via the mitochondrial pathway in murine breast cancer cells

Cited by 25 publications

References 35 publications

Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells

Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells

Demethoxycurcumin induces the apoptosis of human lung cancer NCI-H460 cells through the mitochondrial-dependent pathway

HS-1793, a resveratrol analogue, induces cell cycle arrest and apoptotic cell death in human breast cancer cells

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