2022
DOI: 10.21203/rs.3.rs-2200026/v1
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The Novel Role of Midbody-Associated mRNAs in Regulating Abscission

Abstract: Midbodies (MBs) have been shown to function during telophase as a recruiting hub, especially for ESCRT-III complex subunits, including CHMP4B, to regulate the abscission step of cytokinesis. However, the molecular machinery governing specific protein targeting and activation at the MB remains poorly understood. Until recently, it was thought that abscission regulating proteins, such as ESCRT-III complex subunits, accumulate at the MB by directly or indirectly binding to the MB resident protein, CEP55. However,… Show more

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