2022 Help me understand this report
The Nrf1 transcription factor is induced by patulin and protects against patulin cytotoxicity
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“…In addition, NFE2L1 also participate in metal-based chemotherapy. Several metal compounds can disrupt UPS and interfere with proteasome function [ 171 ], thus NFE2L1 can mediate detoxification of metal exposure by maintaining proteostasis to protect cells from patulin cytotoxicity [ 172 ], and cadmium toxicity [ 173 ]. Persistent toxic stress can induce several cancers, for instance, prolonged arsenic exposure is highly linked to lung cancer development.…”
Section: Nfe2li-mediated Diseases and Therapeutic Interventionmentioning
confidence: 99%
“…In addition, NFE2L1 also participate in metal-based chemotherapy. Several metal compounds can disrupt UPS and interfere with proteasome function [ 171 ], thus NFE2L1 can mediate detoxification of metal exposure by maintaining proteostasis to protect cells from patulin cytotoxicity [ 172 ], and cadmium toxicity [ 173 ]. Persistent toxic stress can induce several cancers, for instance, prolonged arsenic exposure is highly linked to lung cancer development.…”
Section: Nfe2li-mediated Diseases and Therapeutic Interventionmentioning
confidence: 99%
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