The nuclear 16-kD protein methylation increases in the early period of liver regeneration in a hepatectomized rat

Lee, Kyounghwa; Lee, Kyung Mi; Kim, Tae Jin; Kim, Meyoung Kon; Han, Jong Seo l; Hong, Yaoqin; Park, Gil Hong; Lee, Kyo Won

doi:10.1038/emm.2004.72

Cited by 8 publications

(1 citation statement)

References 21 publications

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“…Lee et al showed that p16 undergoes methylation after PH which correlated with liver proliferation. 57 Another study of liver proliferation in aged mice revealed that p16 is elevated in livers of old mice and contributes to the weak proliferative response of livers to PH. 58 Studies of 130 old human patients who underwent hepatectomy showed that these patients had much higher levels of p16 and that these levels negatively correlated with liver regeneration.…”

Section: 54mentioning

confidence: 99%

Elimination of Tumor Suppressor Proteins during Liver Carcinogenesis

Timchenko

Lewis²

2014

Cancer Stud Mol Med Open J

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Liver cancer is one of the most lethal cancers. Quiescent liver expresses up to 20 tumor suppressor proteins including Rb, p53, CCAAT-Enhancer-Binding Protein (C/EBP)α, Hepatocyte Nuclear Factor (HNF4)α and p16 and it is well protected from development of liver cancer. However, the negative control of liver proliferation by these factors and other tumor suppressor genes is eliminated in liver cancer. Studies of liver regeneration after surgery and injury have provided fundamental mechanisms on how liver neutralizes tumor suppressor proteins for the time of regeneration; however, studies of liver cancer in animal models and in human samples showed several additional pathways of this neutralization. One of these additional pathways includes activation of a small subunit of the proteasome, Gankyrin. Gankyrin is dramatically increased in human hepatocellular carcinoma (HCC) and in animal models of carcinogenesis. Once activated Gankyrin triggers degradation of main tumor suppressor proteins during development of liver cancer using slightly different mechanisms. Recent studies identified mechanisms which repress Gankyrin in quiescent livers and mechanisms of activation of Gankyrin in liver cancer. These mechanisms involve a communication between Farnesoid X Receptor (FXR) signaling and chromatin remodelling proteins mediated by members of C/EBP family. It has been recently shown that C/EBPα plays a critical role in this network and that the activation of C/EBPα in cirrhotic livers with HCC inhibits cancer progression. This C/EBPα-dependent inhibition of liver cancer involves activation of a majority of tumor suppressor genes and repression of tumor initiating pathways such as β-catenin and c-myc. These recent findings provide a background for FXR-based and C/EBPα-based approaches to treat liver cancer.

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Section: 54mentioning

confidence: 99%

Elimination of Tumor Suppressor Proteins during Liver Carcinogenesis

Timchenko

Lewis²

2014

Cancer Stud Mol Med Open J

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The potential roles of p53 tumor suppressor in nucleotide excision repair (NER) and base excision repair (BER)

Seo

Jung²

2004

Exp Mol Med

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The upstream sequence of Mycobacterium leprae 18-kDa gene confers transcription repression activity in orientation-independent manner

Kim

You²

2004

Exp Mol Med

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A bstractIn order to understand the role of the upstream region of the M ycobacterium leprae 18-kD a gene on the g en e regulation, th e region w as divided in to tw o at th e -50 p o sitio n fro m th e first start codon of the gene and their effect on transcription w as exam in ed by u sin g a L acZ transcriptional repo rter g en e assay. T he presen ce o f each of th ese tw o region s conferred transcription repressio n no t o nly on its co gnate M . lep raerae 18-kD a gene p rom oter, bu t also on a hetero logo us p rom oter such as the M yco bacteriu m b ovis B C G hsp65 gene prom o ter. M oreover, it w as found that these regions could confer transcription repression activity in both cases in an o rien tation-ind ep en dent m ann er. Thu s, these results indicate that the up stream reg ion of the M . leprae 18-kD a gene harbors transcription repressio n resp onsive elem en t(s) actin g as an operator and can be further divided into tw o sep arately functional region s, sug gesting a b ipartite structu re of the elem ent(s). T he identification of transcription repression activity of the u pstream region in the M . leprae 18-kD a g en e w ill co n trib u te g reatly fo r th e u n d erstan ding o f th e 18-kD a gene reg ulatio n m echanism , and provide also useful inform ation for the m anipu lation of m ycobacterium gene exp ression.

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The nuclear 16-kD protein methylation increases in the early period of liver regeneration in a hepatectomized rat

Cited by 8 publications

References 21 publications

Elimination of Tumor Suppressor Proteins during Liver Carcinogenesis

Elimination of Tumor Suppressor Proteins during Liver Carcinogenesis

The potential roles of p53 tumor suppressor in nucleotide excision repair (NER) and base excision repair (BER)

The upstream sequence of Mycobacterium leprae 18-kDa gene confers transcription repression activity in orientation-independent manner

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