The nuclear receptor LXRα controls the functional specialization of splenic macrophages

A-González, Noelia; Guillén, José Ángel; Gallardo, Germán; Diaz, Moises; Rosa, Juan Vladimir de la; Hernández, Irene; Casanova-Acebes, María; López, Félix; Tabraue, Carlos; Beceiro, Susana; Hong, Cynthia; Lara, Pedro C.; Andújar, Miguel; Arai, Satoko; Miyazaki, Toru; Li, Senlin; Corbí, Ángel L.; Tontonoz, Peter; Hidalgo, Andrés; Castrillo, Antonio

doi:10.1038/ni.2622

Cited by 163 publications

(123 citation statements)

References 48 publications

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“…Splenic marginal-zone macrophage development is dependent on the nuclear receptor LXR and functions to limit bloodborne infections (A-Gonzalez et al, 2013). Although the precise origin of marginal-zone macrophages is not known, these cells proliferate in the first weeks of life.…”

Section: Monocyte and Macrophage Dynamics And Function In Tissuesmentioning

confidence: 99%

Origin and Functions of Tissue Macrophages

2014

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Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult tissue macrophages originate during embryonic development and not from circulating monocytes. Each tissue has its own composition of embryonically derived and adult-derived macrophages, but it is unclear whether macrophages of distinct origins are functionally interchangeable or have unique roles at steady state. This new understanding also prompts reconsideration of the function of circulating monocytes. Classical Ly6chi monocytes patrol the extravascular space in resting organs, and Ly6clo nonclassical monocytes patrol the vasculature. Inflammation triggers monocytes to differentiate into macrophages, but whether resident and newly recruited macrophages possess similar functions during inflammation is unclear. Here, we define the tools used for identifying the complex origin of tissue macrophages and discuss the relative contributions of tissue niche versus ontological origin to the regulation of macrophage functions during steady state and inflammation.

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Section: Monocyte and Macrophage Dynamics And Function In Tissuesmentioning

confidence: 99%

Origin and Functions of Tissue Macrophages

2014

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“…For example, colony stimulating factor 1 (CSF1/M-CSF) is essential for Kupffer cells 90 , TGFβ1 and IL-34 for microglia and Langerhans cells 88, 91, 92, 93 , colony stimulating factor 2 (CSF2/GM-CSF) for the differentiation or maintenance of alveolar macrophages in mice and humans 94, 95, 96, 97, 98, 99 , and retinoic acid and GATA6 for large peritoneal macrophages 88, 100, 101 . SPIC is important for the development of red pulp macrophages 102 , while LXR-deficient mice are defective in the generation of maginal zone and metallophilic macrophages 103 .…”

Section: Conclusion and Perspectives On Macrophage Functionsmentioning

confidence: 99%

The development and maintenance of resident macrophages

2015

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The molecular and cellular mechanisms that underlie the many roles of macrophages in health and disease states in vivo remain poorly understood. The purpose of this Review is to present and discuss current knowledge on the developmental biology of macrophages, as it underlies the concept of a layered myeloid system composed of ‘resident’ macrophages that mostly originate from yolk sac progenitors and of ‘passenger’ or ‘transitory’ myeloid cells that originate and renew from bone marrow hematopoietic stem cells, and to provide a framework to investigate the functions of macrophages in vivo.

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“…Several examples of transcription factors that dictate tissue-specific transcription programs in macrophages have been reported, and the deletion of these transcription factors resulted in the ablation of particular tissue macrophage subsets (Kohyama et al, 2009; A-Gonzalez et al, 2013; Takayanagi et al, 2002), suggesting their involvement in the differentiation of the corresponding macrophage populations. In addition, mature macrophages can undergo functional polarization in response to environmental signals (Stout et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages

Okabe

Medzhitov

2014

Cell

760

859

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SUMMARY Tissue-resident macrophages are highly heterogeneous in terms of their functions and phenotypes as a consequence of adaptation to different tissue environments. Local tissue-derived signals are thought to control functional polarization of resident macrophages; however, the identity of these signals remains largely unknown. It is also unknown whether functional heterogeneity is a result of irreversible lineage-specific differentiation or a consequence of continuous but reversible induction of diverse functional programs. Here, we identified retinoic acid as a signal that induces tissue-specific localization and functional polarization of peritoneal macrophages through the reversible induction of transcription factor GATA6. We further found that GATA6 in macrophages regulates gut IgA production through peritoneal B-1 cells. These results provide insight into the regulation of tissue-resident macrophage functional specialization by tissue-derived signals.

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The nuclear receptor LXRα controls the functional specialization of splenic macrophages

Cited by 163 publications

References 48 publications

Origin and Functions of Tissue Macrophages

Origin and Functions of Tissue Macrophages

The development and maintenance of resident macrophages

Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages

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