“…BRK substrates include RNA-binding proteins (Sam68 (Coyle et al, 2003;Derry et al, 2000;Lukong et al, 2005), SLM-1/2 (Haegebarth et al, 2004), and the polypyrimidine tractbinding protein-associated splicing factor (PSF) (Lukong et al, 2009)), transcription factors (STAT3 (Liu et al, 2006) and STAT5A/B (Weaver and Silva, 2007)), adaptor molecules (STAP-2) (Mitchell et al, 2000), and a variety of signaling molecules (paxillin (Chen et al, 2004), p190RhoGAP (Shen et al, 2008), kinesin-associated protein 3A (KAP3A) (Lukong and Richard, 2008), Akt (Zhang et al, 2005), -catenin (Palka-Hamblin et al, 2010), and ARAP1 (Arf-GAP, Rho-GAP, ankyrin repeat and PH domain-containing protein 1; also known as centaurin δ-2) (Kang et al, 2010)). Although BRK expression is known to induce tyrosine phosphorylation in some of these, similar actions in others have yet to be confirmed.…”