The nucleolar protein GNL3 prevents resection of stalled replication forks
Rana Lebdy,
Marine Canut,
Julie Patouillard
et al.
Abstract:Faithful DNA replication requires specific proteins that protect replication forks and so prevent the formation of DNA lesions that may damage the genome. Identification of new proteins involved in this process is essential to understand how DNA lesions accumulate in cancer cells and how they tolerate them. Here, we show that human GNL3/nucleostemin, a GTP‐binding protein localized mostly in the nucleolus and highly expressed in cancer cells, prevents nuclease‐dependent resection of nascent DNA in response to … Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.