The optical potential without any free parameters for 7 Li-nucleus interaction system is studied in a microscopic approach. It is obtained by folding the microscopic optical potentials of the constituent nucleons of 7 Li over their density distributions. We employ an isospin-dependent nucleon microscopic optical potential, which is based on the Skyrme nucleon-nucleon effective interaction and derived by using the Green's function method, to be the nucleon optical potential. Harmonic oscillator shell model is used to describe the internal wave function of 7 Li and get the nucleon density distribution. The 7 Li microscopic optical potential is used to predict the reaction cross sections and elastic scattering angular distributions for target range from 27 Al to 208 Pb and energy range below 450 MeV. Generally the results can reproduce the measured data reasonably well. In addition, the microscopic optical potential is comparable to a global phenomenological optical potential in fitting the presently existing measured data generally.