The Nucleotide Oligomerization Domain-Like Receptors in Kidney Injury

Wang, Xiaojie

doi:10.1159/000444736

Cited by 7 publications

(3 citation statements)

References 70 publications

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“…NLRs are recently identified intracellular PRRs that are essential to innate immune responses and tissue homeostasis. Emerging evidence suggested a potential role of NLRs in kidney disease (47,48). Expression of Nod1, Nod2, or RICK induces NF-kB activation (49).…”

Section: Discussionmentioning

confidence: 99%

Single-Cell Profiling Reveals Transcriptional Signatures and Cell-Cell Crosstalk in Anti-PLA2R Positive Idiopathic Membranous Nephropathy Patients

Shen

Lin

et al. 2021

Front. Immunol.

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Idiopathic membranous nephropathy (IMN) is an organ-specific autoimmune disease of the kidney glomerulus. It may gradually progress to end-stage renal disease (ESRD) characterized by increased proteinuria, which leads to serious consequences. Although substantial advances have been made in the understanding of the molecular bases of IMN in the last 10 years, certain questions remain largely unanswered. To define the transcriptomic landscape at single-cell resolution, we analyzed kidney samples from 6 patients with anti-PLA2R positive IMN and 2 healthy control subjects using single-cell RNA sequencing. We then identified distinct cell clusters through unsupervised clustering analysis of kidney specimens. Identification of the differentially expressed genes (DEGs) and enrichment analysis as well as the interaction between cells were also performed. Based on transcriptional expression patterns, we identified all previously described cell types in the kidney. The DEGs in most kidney parenchymal cells were primarily enriched in genes involved in the regulation of inflammation and immune response including IL-17 signaling, TNF signaling, NOD-like receptor signaling, and MAPK signaling. Moreover, cell-cell crosstalk highlighted the extensive communication of mesangial cells, which infers great importance in IMN. IMN with massive proteinuria displayed elevated expression of genes participating in inflammatory signaling pathways that may be involved in the pathogenesis of the progression of IMN. Overall, we applied single-cell RNA sequencing to IMN to uncover intercellular interactions, elucidate key pathways underlying the pathogenesis, and identify novel therapeutic targets of anti-PLA2R positive IMN.

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Section: Discussionmentioning

confidence: 99%

Single-Cell Profiling Reveals Transcriptional Signatures and Cell-Cell Crosstalk in Anti-PLA2R Positive Idiopathic Membranous Nephropathy Patients

Shen

Lin

et al. 2021

Front. Immunol.

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“…Importantly, recombinant human PGRN has a therapeutic potential for the treatment of AKI [ 86 ]. Accumulating evidence has shown that nucleotide oligomerization domain (NOD)-like receptors (NLRs) are highly involved in the pathogenesis of kidney diseases [ 87 ]. Our studies further indicate that PGRN, at least in part, negatively regulates the inflammatory responses mediated by NOD2, a member of NLRs [ 86 ].…”

Section: Progranulinmentioning

confidence: 99%

The Growth Factors: Potential Biomarkers and Therapeutic Targets in Kidney Diseases

2022

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Background: Kidney diseases are a prevalent health problem worldwide. Although substantial progress has been made in understanding the pathophysiology of kidney disease, currently there is no satisfactory clinical treatment available to prevent or treat kidney disease. Therefore, strategies to establish early diagnosis, identify the key molecules, and develop novel therapeutic interventions to slow the progression of kidney diseases and reduce their complications are encouraged. Summary: The growth factors play a crucial role in the development of kidney diseases. The altered levels of growth factors are usually detected in circulation and urine in the disease course. A growing body of studies has suggested that growth factors, receptors, and related regulators are promising biomarkers for the diagnosis and/or prognosis and potential therapeutic targets for the treatment of kidney diseases. In this review, we summarize recent advances in the potential applications of growth factors for diagnostic biomarkers and therapeutic targets in kidney diseases and highlight their performances in clinical trials. Key Messages: Most diagnostic and therapeutic strategies targeting growth factors are still far from clinical implementation. The better understanding of growth factor-regulated pathophysiology and the progress of new intervention approaches are expected to facilitate the clinical translation of growth factor-based diagnosis and therapy of kidney diseases.

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“…NOD1 is expressed in human and murine renal tubular epithelial cells [ 85 , 86 ]. Renal ischemia/reperfusion injury activates NOD1 due to tubular epithelial apoptosis and inflammation [ 85 , 87 ]. Furthermore, a complex and interesting study linked immunosuppressive drugs such as CsA with NOD1: CsA inhibited the innate renal antibacterial responses of NOD1 in both mice and human transplant recipients [ 75 ].…”

Section: Nod1-related Diseases and Nutrients: The Potential Benefit Of Immunonutrition Approachesmentioning

confidence: 99%

NOD1-Targeted Immunonutrition Approaches: On the Way from Disease to Health

et al. 2021

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Immunonutrition appears as a field with great potential in modern medicine. Since the immune system can trigger serious pathophysiological disorders, it is essential to study and implement a type of nutrition aimed at improving immune system functioning and reinforcing it individually for each patient. In this sense, the nucleotide-binding oligomerization domain-1 (NOD1), one of the members of the pattern recognition receptors (PRRs) family of innate immunity, has been related to numerous pathologies, such as cancer, diabetes, or cardiovascular diseases. NOD1, which is activated by bacterial-derived peptidoglycans, is known to be present in immune cells and to contribute to inflammation and other important pathways, such as fibrosis, upon recognition of its ligands. Since immunonutrition is a significant developing research area with much to discover, we propose NOD1 as a possible target to consider in this field. It is relevant to understand the cellular and molecular mechanisms that modulate the immune system and involve the activation of NOD1 in the context of immunonutrition and associated pathological conditions. Surgical or pharmacological treatments could clearly benefit from the synergy with specific and personalized nutrition that even considers the health status of each subject.

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The Nucleotide Oligomerization Domain-Like Receptors in Kidney Injury

Cited by 7 publications

References 70 publications

Single-Cell Profiling Reveals Transcriptional Signatures and Cell-Cell Crosstalk in Anti-PLA2R Positive Idiopathic Membranous Nephropathy Patients

Single-Cell Profiling Reveals Transcriptional Signatures and Cell-Cell Crosstalk in Anti-PLA2R Positive Idiopathic Membranous Nephropathy Patients

The Growth Factors: Potential Biomarkers and Therapeutic Targets in Kidney Diseases

NOD1-Targeted Immunonutrition Approaches: On the Way from Disease to Health

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