The number of biological parents with alcohol use disorder histories and risk to offspring through age 30

Kosty, Derek; Farmer, Richard F.; Seeley, John R.; Merikangas, Kathleen R.; Klein, Daniel N.; Gau, Jeff M.; Duncan, Susan C.; Lewinsohn, Peter M.

doi:10.1016/j.addbeh.2019.106196

Cited by 9 publications

(9 citation statements)

References 40 publications

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“…Considering that FH+2 youth may experience greater vulnerability across many domains of functioning and psychopathologies [ 8 , 29 ], the results from the present study may be capturing reward hypoactivation as a broad liability marker for psychopathology. Indeed, reward dysfunction has been identified as a transdiagnostic marker of psychopathology [ 30 ].…”

Section: Discussionmentioning

confidence: 93%

“…One potential source of this difference in vulnerability is having two biological parents with histories of AUD as opposed to one. A recent study examining AUD risk trajectories in youth from ages 14 to 30 found a positive linear association between the number of parents with AUD and offspring AUD [ 8 ]. Similarly, in a study of 12- to 15-year-olds, youth with both a father and mother who engaged in heavy episodic drinking were at heightened risk for earlier and heavier drinking compared to youth whose parents were not heavy drinkers [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD Study® and Michigan Longitudinal Study

et al. 2022

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Having a family history of alcohol use problems (FH+) conveys risk for alcohol use in offspring. Reward-related brain functioning may play a role in this vulnerability. The present study investigated brain function in the nucleus accumbens (NAcc) associated with the anticipation of reward in youth with two biological parents with alcohol use problems (FH+2), one biological parent with alcohol use problems (FH+1), and no biological parents with alcohol use problems (FH-). Participants were from the large, national Adolescent Brain Cognitive Development (ABCD) Study (mean age: 9.93; 48% female; FH+2 n = 223, FH+1 n = 1447, FH- n = 9690) and the Michigan Longitudinal Study (MLS), consisting of community-recruited families with high rates of alcohol use disorder (mean age: 10.54; 39.3% female; FH+2 n = 40, FH+1 n = 51, FH- n = 40). Reward anticipation was measured by the monetary incentive delay task. Regression models were used to assess associations between FH status and the anticipation of large rewards in right and left NAcc regions of interest. In both studies, FH+2 youth showed blunted anticipatory reward responding in the right NAcc compared to FH+1 youth. In the MLS, FH+2 youth also had blunted anticipatory reward responding in the right NAcc compared to the FH- group. Convergent results across two separate samples provide insights into a unique vulnerability of FH+2 youth and suggest that binary FH+ versus FH- categorizations may obscure important differences within FH+ youth.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD Study® and Michigan Longitudinal Study

et al. 2022

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“…The 28 articles identified on parental alcohol intake only (i.e., not specifying children's observation of alcohol use) linked greater frequency and/or volume of consumption to negative alcohol‐related outcomes for their children [46, 79, 80, 83–107]. This effect was observed across numerous countries and cultural contexts, including Australia [87], Brazil [85, 90], Chile [86], China [105], Germany [97], Ireland [98], Japan [88], Mexico [107], Slovenia [96], Spain [101], Taiwan [79], the United Kingdom [91, 93, 94] and the United States [89, 92].…”

Section: Resultsmentioning

confidence: 99%

The potential adverse effects of minors' exposure to alcohol‐related stimuli via licenced venues: A narrative review

Booth,

Miller,

Pettigrew

2023

Drug and Alcohol Review

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IssuesYoung people are particularly impressionable when it comes to forming expectations and attitudes around alcohol consumption. Any stimuli that normalise and foster positive expectations around alcohol use may increase the risk of underage alcohol consumption. Alcohol venues that market themselves as being appropriate ‘family friendly’ establishments for children risk exposing minors to environments that are saturated with alcohol‐related stimuli. However, research examining how exposure to licenced venues affects underage people is very limited. The aim of this narrative review was to identify and synthesise relevant evidence to better understand how attending these venues might affect minors.ApproachA narrative review of research published between January 2016 and November 2022 was conducted to investigate the potential effects on underage people of exposure to licenced venues and stimuli encountered in/around these venues. Examined stimuli included alcohol advertising, people consuming alcohol and alcohol outlets.Key FindingsThe reviewed literature indicates that the risk of alcohol‐related harm among minors is likely to increase with greater exposure to alcohol venues due to the associated exposure to alcohol advertising, exposure to others consuming alcohol and higher outlet density. In combination, these factors are likely to normalise alcohol consumption for minors and create positive alcohol expectancies.Implications and ConclusionVenues serving alcohol should be discouraged from targeting families and parents should be warned about the risks associated with taking minors to venues where alcohol is sold and consumed.

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“…Çalışmamızın sonuçlarına baktığımızda, düşük benlik saygısı yanısıra biyolojik ve koşullandırıcı bir yatkınlık faktörü olan "ailede madde bağımlısı olma" diğer risk faktörlerinin önüne geçiyor görünmektedir. Literatürde ailede madde kullanımı varlığının madde bağımlılığı gelişmesinde ve olumsuz seyrinde öngördürücü olduğunu bildiren çalışmalar bulunmaktadır (56)(57)(58)(59). Babanın madde kullanımı, daha sonraki kuşakların nörobiyolojisinde ve öğrenilmiş davranışlarında belirgin değişiklikler oluşturmaktadır (60).…”

Section: Discussionunclassified

Madde Bağımlılığının Gelişiminde Birikimli Risk Faktörlerinin Rolü

Ünal

Mutlu²,

Topaktaş³

2021

Bağımlılık Dergisi

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Objective: In this study, the hypothesis that the cumulative effect of possible risk factors is more effective in the development of substance addiction was tested. Method: 200 substance addicts and 200 healthy controls were included in the study. SCID-I clinical interview, sociodemographic data form, Rosenberg self-esteem scale, Parenting Styles Scale were applied to the subjects. A questionnaire was given to identify risks related to family and childhood life. 14 variables were considered as risk factors. The sample was divided into high and low risk groups. Results: After the age of 14, parental loss and separation, definition of family relationships as "bad", presence of substance addiction in family members, low self-esteem, and father's lack of interest / acceptance were more common in substance addicts than in healthy controls. Separation from parents before the age of 13 and continuous family quarrels were reported with a higher rate in healthy controls. The effects of mother control dimension, father acceptance dimension and self-esteem were found to be high in the development of addiction. The effects of mother control dimension, father acceptance dimension and self-esteem were found to be high in the development of addiction. Discusion: When the risk factors are considered individually, the substance addiction group is disadvantaged, while the risk ratio is equalized in both groups in terms of cumulative risk factors. This situation brings to mind the concept of "resilience". The fact that healthy controls did not develop addiction was interpreted as that they might have developed appropriate coping skills against the negative living conditions they encountered from childhood. In addition to reducing risk factors in the prevention of substance addiction, it would be an appropriate approach to focus on practices that will increase resilience. . Keywords: Substance abuse, cumulative risk, parenting style, self-esteem ÖZ Amaç: Çalışmamızda, olası risk faktörlerinin birikimli etkisinin madde bağımlılığı gelişmesinde tek tek risk faktörlerinin varlığından daha etkili olduğu hipotezi test edilmiştir. Yöntem: Çalışmaya 200 madde bağımlısı, 200 sağlıklı kontrol dahil edilmiştir. Deneklere SCID-I klinik görüşme, sosyodemografik veri formu, Rosenberg Benlik Saygısı Ölçeği, Ebeveynlik Stilleri Ölçeği uygulandı. Aile ve çocukluk yaşamı ile ilgili riskleri belirlemek için bir anket formu verildi. Risk faktörü olarak 14 değişken belirlendi. Örneklem yüksek ve düşük risk grubu olarak ikiye ayrıldı. Bulgular: 14 yaşından sonra ebeveyn kaybı ve ebeveynden ayrılık yaşama, aile ilişkilerini "kötü" olarak tanımlama, ailede madde bağımlılığı varlığı, düşük benlik saygısı, babanın ilgi / kabul eksikliği madde bağımlılarında sağlıklı kontrollere göre daha yaygındı. Sağlıklı kontrollerde 13 yaşından önce ebeveynden ayrılma ve sürekli aile kavgası madde bağımlılarına göre daha yüksek oranda bildirilmişti. Bağımlılığın gelişiminde anne kontrol boyutu, baba kabul boyutu ve benlik saygısının etkisi yüksek olarak belirlendi. Tartı...

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The number of biological parents with alcohol use disorder histories and risk to offspring through age 30

Cited by 9 publications

References 40 publications

Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD Study® and Michigan Longitudinal Study

Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD Study® and Michigan Longitudinal Study

The potential adverse effects of minors' exposure to alcohol‐related stimuli via licenced venues: A narrative review

Madde Bağımlılığının Gelişiminde Birikimli Risk Faktörlerinin Rolü

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