The number of multinucleated trophoblastic giant cells in the basal decidua is decreased in retained placenta

Beekhuizen, Heleen J. van; Joosten, Irma; Groot, A.N.J.A. de; Lotgering, F.K.; Laak, J.A.W.M. van der; Bulten, Johan

doi:10.1136/jcp.2009.065953

Cited by 9 publications

(6 citation statements)

References 28 publications

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“…5A, insert 3). A known distinctive feature of invasive placentation is the relative paucity of MNGCs seen in late normal placentation 16,28. Our semiquantitative analysis confirmed this observation (% MNGC average ± SEM, accreta: 3±1% vs. normal placental bed biopsies: 36±13%, P =0.001).…”

Section: Resultssupporting

confidence: 82%

Accreta complicating complete placenta previa is characterized by reduced systemic levels of vascular endothelial growth factor and by epithelial-to-mesenchymal transition of the invasive trophoblast

Wehrum

Buhimschi

Salafia³

et al. 2011

American Journal of Obstetrics and Gynecology

105

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OBJECTIVE-To characterize serum angiogenic factor profile of women with complete placenta previa and determine if invasive trophoblast differentiation characteristic of accreta, increta or percreta shares features of epitehelial-mesenchymal-transition (EMT).STUDY DESIGN-We analyzed gestational age matched serum samples from 90 pregnant women with either complete placenta previa (n=45) or uncomplicated pregnancies (n=45). Vascular-endothelial-growth-factor (VEGF), placental-growth-factor (PlGF) and soluble fms-liketyrosine-kinase-1 (sFlt-1) were immunoassayed. VEGF and phosphotyrosine (P-Tyr) immunoreactivity was surveyed in histological specimens relative to expression of vimentin and cytokeratin-7. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. RESULTS-Women Disclosure statement:The authors have nothing to disclose CONTRIBUTIONS TO AUTHORSHIP MJW, EF, IAB and CSB formulated the hypothesis, designed the study, collected, analyzed, and interpreted the data and drafted the manuscript. MJW and CSB recruited patients and together with ST, MOB, EW, KC, AKS and CL collected biological specimens and followed the patients prospectively to the point of delivery. MJW and GZ conducted the ELISA assays and the immunohistochemistry experiments. IAB, MJW, CSB and CMS evaluated and performed the histological analysis of our specimens. All the co-authors participated with aspects of study design, critical interpretation of the data, contributed to writing of the paper and have reviewed and approved the final version. NIH Public Access Author ManuscriptAm J Obstet Gynecol. Author manuscript; available in PMC 2012 May 1. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript CONCLUSIONS-Lower systemic free VEGF and a switch of the interstitial EVT to a metastable cell phenotype characterize placenta previa with excessive myometrial invasion.

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Section: Resultssupporting

confidence: 82%

Accreta complicating complete placenta previa is characterized by reduced systemic levels of vascular endothelial growth factor and by epithelial-to-mesenchymal transition of the invasive trophoblast

Wehrum

Buhimschi

Salafia³

et al. 2011

American Journal of Obstetrics and Gynecology

105

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“…Another clinical condition associated with shallow implantation, extravillous trophoblast dysfunction, and its placental accumulation is the placenta creta [5][6][7]. In most cases of the adherent placenta, MTGC were seen in the decidua basalis and in none of the control placentas [32]. On the contrary, placenta previa is associated with significantly higher myometrial trophoblastic giant cell infiltration and presence of physiologic changes in the myometrial spiral arterioles [33].…”

Section: Discussionmentioning

confidence: 96%

Sensitivity and specificity of finding of multinucleate trophoblastic giant cells in decidua in placentas from high-risk pregnancies

Stanek

Biesiada

2012

Human Pathology

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“…In women with focal placenta accreta, the numbers of myometrial multinucleate trophoblast giant cells are highly reduced in areas lacking decidua compared with areas with intact decidua, suggesting that decidual derived factors mediate or initiate this fusion process as the cells move towards the myometrium ( Hannon et al 2012 ). Furthermore, in placenta adhesiva, the mildest form of adherent placenta in which decidua basalis is present (van Beekhuizen et al 2009 ), numbers of uNK cells were markedly reduced (van Beekhuizen et al 2010 ). It is tempting to speculate that uNK cells may play a role in the fusion of mononuclear to multinucleate trophoblast.…”

Section: Uterine Nk Cell: Trophoblast Cell Interactionsmentioning

confidence: 95%

The Role of Uterine NK Cells in Normal Reproduction and Reproductive Disorders

Bulmer

Lash

2015

Advances in Experimental Medicine and Biology

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The human endometrium contains a substantial population of leucocytes which vary in distribution during the menstrual cycle and pregnancy. An unusual population of natural killer (NK) cells, termed uterine NK (uNK) cells, are the most abundant of these cells in early pregnancy. The increase in number of uNK cells in the mid-secretory phase of the cycle with further increases in early pregnancy has focused attention on the role of uNK cells in early pregnancy. Despite many studies, the in vivo role of these cells is uncertain. This chapter reviews current information regarding the role of uNK cells in healthy human pregnancy and evidence indicating their importance in various reproductive and pregnancy problems. Studies in humans are limited by the availability of suitable tissues and the limitations of extrapolation from animal models.

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The number of multinucleated trophoblastic giant cells in the basal decidua is decreased in retained placenta

Cited by 9 publications

References 28 publications

Accreta complicating complete placenta previa is characterized by reduced systemic levels of vascular endothelial growth factor and by epithelial-to-mesenchymal transition of the invasive trophoblast

Accreta complicating complete placenta previa is characterized by reduced systemic levels of vascular endothelial growth factor and by epithelial-to-mesenchymal transition of the invasive trophoblast

Sensitivity and specificity of finding of multinucleate trophoblastic giant cells in decidua in placentas from high-risk pregnancies

The Role of Uterine NK Cells in Normal Reproduction and Reproductive Disorders

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