The number of regulatory Foxp3+ T-cells in different stages of malignant transformation of large intestinal polyps

Rubinkiewicz, Mateusz; Migaczewski, Marcin; Hankus, Jerzy; Dembiński, Marcin; Pędziwiatr, Michał; Okoń, Krzysztof; Pisarska, Magdalena; Budzyński, Andrzej

doi:10.1016/j.advms.2016.03.008

Cited by 10 publications

(8 citation statements)

References 18 publications

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“…A class of cells which has gained special interest and been extensively studied in cancers is regulatory lymphocytes [4,5,6,20]. Merlo et al [4] published an analysis of regulatory lymphocytes in breast carcinoma, in which they reported a significant survival benefit in FOXP3 negative cases.…”

Section: Discussionmentioning

confidence: 99%

“…Petersen et al [5] reviewed cases of non-small-cell pulmonary carcinomas and found that patients with a higher FOXP3 positive/overall T lymphocyte ratio were at greater risk of relapse. Salama et al [6] analyzed the popu- [20], who analyzed colorectal adenoma and cancers, observed that the mean FOXP3/CD4 cell ratio increases during the progression to malignancy. The number of studies on FOXP3 positive cells in prostatic carcinoma is more limited.…”

Section: Discussionmentioning

confidence: 99%

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Prostate cancer with different ERG status may show different FOXP3-positive cell numbers

Kaczmarczyk-Sekuła¹,

Gałązka²,

Glajcar³

et al. 2016

pjp

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Prostatic carcinoma is the most frequent cancer in males in the Western world. A significant proportion of these cancers have a recurrent translocation involving ETS family genes, which leads to the overexpression of ERG transcription factor. Prostate cancers, which bear this mutation, differ in a number of features, including tumor microenvironment. One of the components of the tumor microenvironment is FOXP3 positive lymphocytes, which may participate in breaking immunosurveillance and promoting tumor growth. 2 for all cases, 21.43/ mm 2 for the ERG negative and 42.28/mm 2 for the ERG positive group (p < 0.02). There were no significant relationships between FOXP3 positive cell count and any other parameters studied. Our results suggest that the immune response may differ between ERG negative and ERG positive prostatic carcinomas.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prostate cancer with different ERG status may show different FOXP3-positive cell numbers

Kaczmarczyk-Sekuła¹,

Gałązka²,

Glajcar³

et al. 2016

pjp

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“…The role of Tregs remains controversial. It is worth mentioning that we also found an increased number of Foxp3 cells in tumor microenvironment in early stages of colorectal carcinoma development, such as adenoma with high-grade dysplasia ( 18 ). Waniczek et al .…”

Section: Discussionmentioning

confidence: 55%

Perioperative Changes in Lymphocyte Subpopulations in Patients Undergoing Surgery for Colorectal Cancer

Rubinkiewicz

Siemińska

Małczak

et al. 2019

ACC

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SUMMARYSurgical procedure has immense impact on the immune balance. However, little is known about perioperative changes in T regulatory and Th17 lymphocyte subpopulations in patients undergoing colorectal resection. Patients with resectable colon cancer were enrolled in the study. Blood samples were obtained on two occasions, i.e. before the procedure and two days after the surgery. We also recruited a control group of young, healthy individuals. Lymphocyte subpopulations were analyzed with the use of flow cytometry. Investigated subpopulations consisted of total lymphocyte count, CD4+, CD8+, T regulatory Foxp3+ (Tregs), Th17 lymphocytes and white blood cell (WBC) count. There were significant differences in immune cell levels before and after the surgery. Reduction was recorded in the CD4+, CD8+, Tregs and total lymphocyte counts (p=0.002, p=0.01, p=0.008 and p=0.001, respectively). Increase was observed in total WBC and Th17 cells, however, Th17 lymphocytes did not reach statistical significance (p=0.01 and p=0.5, respectively). In conclusion, surgical intervention caused changes in all lymphocyte subpopulations investigated in patients undergoing surgery for colorectal cancer. However, it seemed to be an effect of perioperative trauma. Further studies are needed to investigate the impact of surgical intervention on lymphocyte subpopulations.

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“…Together, they suppress the anti-colorectal tumour immune response in a COX-2-dependent manner [ 72 ]. The number of intraepithelial regulatory T cells was observed to increase when adenomatous polyps with low-grade dysplasia were compared to advanced adenomas and CRCs [ 73 , 74 ]. Interestingly, this accumulation appears specific to sporadic adenomas and has not been reported in familial adenomatous polyposis [ 75 ].…”

Section: Immunological Environment Within Polypsmentioning

confidence: 99%

Genomic, Microbial and Immunological Microenvironment of Colorectal Polyps

Tse

Welham

Engel

et al. 2021

Cancers

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Colorectal cancer (CRC) develops from pre-cancerous cellular lesions in the gut epithelium, known as polyps. Polyps themselves arise through the accumulation of mutations that disrupt the function of key tumour suppressor genes, activate proto-oncogenes and allow proliferation in an environment where immune control has been compromised. Consequently, colonoscopic surveillance and polypectomy are central pillars of cancer control strategies. Recent advances in genomic sequencing technologies have enhanced our knowledge of key driver mutations in polyp lesions that likely contribute to CRC. In accordance with the prognostic significance of Immunoscores for CRC survival, there is also a likely role for early immunological changes in polyps, including an increase in regulatory T cells and a decrease in mature dendritic cell numbers. Gut microbiotas are under increasing research interest for their potential contribution to CRC evolution, and changes in the gut microbiome have been reported from analyses of adenomas. Given that early changes to molecular components of bowel polyps may have a direct impact on cancer development and/or act as indicators of early disease, we review the molecular landscape of colorectal polyps, with an emphasis on immunological and microbial alterations occurring in the gut and propose the potential clinical utility of these data.

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The number of regulatory Foxp3+ T-cells in different stages of malignant transformation of large intestinal polyps

Cited by 10 publications

References 18 publications

Prostate cancer with different ERG status may show different FOXP3-positive cell numbers

Prostate cancer with different ERG status may show different FOXP3-positive cell numbers

Perioperative Changes in Lymphocyte Subpopulations in Patients Undergoing Surgery for Colorectal Cancer

Genomic, Microbial and Immunological Microenvironment of Colorectal Polyps

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