The Number of Removed Lymph Nodes for an Acceptable False Negative Rate in Sentinel Lymph Node Biopsy for Breast Cancer

Koo, Bon Young; Jeong, Seong Gu; Eom, Tae Ik; Kang, Hee Joon; Kim, Lee Su

doi:10.4048/jbc.2009.12.2.100

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…1 [18,[21][22][23]. Accoding to previous studies [24][25][26][27], the likelihood of a false-negative SLN nding was signi cantly decreased, when SLNs detection number reaches 3, the FNR can reached an acceptable level of less than 5%, the relationship between SLNs removed and FNR was shown in Fig. 2.…”

Section: Discussionmentioning

confidence: 50%

Intraoperative palpation increases the efficiency of sentinel lymph node biopsy but is not necessary for every operation

Qin

Zheng

et al. 2021

Preprint

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Background Although intraoperative palpation (IOP) is recommended during the sentinel lymph node biopsy (SLNB), its actual effect on SLNB remains unclear. Meanwhile, controversy exists regarding whether IOP is necessary for all SLNB. The study examined the impacts of IOP on SLNB and determined whether IOP is necessary for every operation. Methods 126 patients with early stage breast cancer underwent SLNB using Indocyanine green (n = 64) and Methylene blue (n = 62). Traced lymph nodes (TLNs) were resected, followed by the palpated lymph nodes (PLNs) surrounding the original TLNs. and we analyzed the results (with and without IOP) in terms of detection rate, number of removed SLNs and detection rate of metastatic SLNs. Results Without IOP, the detection rates of the two group were 90.6%(58/64), 88.7%(55/62), but with IOP, all the rates increased to 100% (p < 0.05).The mean number also increased (With palpitation: Without palpitation = 3.5 : 2.9; 3.1 : 1.8, p < 0.05).73 (57.9%) patients were detected with PLNs and 13 (10.3%) were detected with only PLNs. In the 26 patients detected with metastatic nodes, 4 (15.4%) were detected with only palpated metastatic nodes. Conclusions Intraoperative palpation increases detection rate and number of SLNs and reduced the potential false-negative rate. But intraoperative palpation is not necessary for all SLNB when the number of TLNs reaches three or more.

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Section: Discussionmentioning

confidence: 50%

Intraoperative palpation increases the efficiency of sentinel lymph node biopsy but is not necessary for every operation

Qin

Zheng

et al. 2021

Preprint

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“…Actually, the numbers of removed SLNs were informative in predicting metastasis in axillary lymph node. According to previous studies [181920], the increase in the number of removed SLNs would result in enhanced accuracy and decline in false negative rate. Particularly, when SLNs detection number reaches 4, the accuracy rate can be stabilized at 95% and the false negative rate can be controlled below 5%.…”

Section: Discussionmentioning

confidence: 99%

“…The false negative rate can be controlled below 11% and the accuracy rate can be over 94% when the number of SLNs reaches 3. When 4 SLNs were detected, the false negative rate was below 2%, and the accuracy rate was above 98% [181920].…”

Section: Discussionmentioning

confidence: 99%

Comparative study of indocyanine green combined with blue dye with methylene blue only and carbon nanoparticles only for sentinel lymph node biopsy in breast cancer

2019

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Purpose The combination of indocyanine green and methylene blue (ICG + MB) was reported to be an efficient tracer method in sentinel lymph node biopsy (SLNB). However, whether this method is superior to MB only or carbon nanoparticles (CN) is controversial. This study was to evaluate the efficacy of the three methods in SLNB for breast cancer, and to analyze its influencing factors. Methods One hundred eighty patients with early breast cancer were recruited and randomly divided into 3 groups. Each group comprising of 60 patients with SLNB using ICG + MB, MB, and CN, respectively. Then the 3 groups were compared in detection rate, mean number of SLNs, and the detection rates and number of metastatic sentinel lymph nodes (SLNs). Results The detection rate of SLNs was 100% (60 of 60) in ICG + MB group, 96.7% (58 of 60), and 98.3% (59 of 60) in MB and CN group, respectively, with no significant difference (P = 0.362). Totally, 204 SLNs (mean ± standard deviation [SD] [range], 3.4 ± 1.4 [2–8]) were detected in ICG + MB group, 102 (1.7 ± 0.7 [0–3]) and 145 (2.4 ± 0.7 [0–6]) in MB and CN group, indicating significant difference (P < 0.001). The detection rate of metastatic SLN was 23.3% (14 of 60) in ICG + MB group, which was higher than 18.3% (11 of 60) and 20% (11 of 60) in MB and CN group, respectively, but showed no statistical significance (P = 0.788). Conclusion ICG + MB method was superior to MB only and CN only methods in the mean number of SLNs, thus predicting axillary lymph node metastasis more accurately. Therefore, in areas where the standard method is not available, ICG + MB may be more suitable as an alternative tracer for SLNB.

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Commentary on "The Number of Removed Lymph Nodes for an Acceptable False Negative Rate in Sentinel Node Biopsy for Breast Cancer"

Nam

Lee

2009

J Breast Cancer

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The Number of Removed Lymph Nodes for an Acceptable False Negative Rate in Sentinel Lymph Node Biopsy for Breast Cancer

Cited by 5 publications

References 27 publications

Intraoperative palpation increases the efficiency of sentinel lymph node biopsy but is not necessary for every operation

Intraoperative palpation increases the efficiency of sentinel lymph node biopsy but is not necessary for every operation

Comparative study of indocyanine green combined with blue dye with methylene blue only and carbon nanoparticles only for sentinel lymph node biopsy in breast cancer

Commentary on "The Number of Removed Lymph Nodes for an Acceptable False Negative Rate in Sentinel Node Biopsy for Breast Cancer"

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