Let f be a positive definite (non-classic) integral quaternary quadratic form. We say f is strongly s-regular if it satisfies a regularity property on the number of representations of squares of integers. In this article, we prove that there are only finitely many strongly s-regular quaternary quadratic forms up to isometry if the minimum of the nonzero squares that are represented by the quadratic form is fixed. Furthermore, we show that there are exactly 34 strongly s-regular diagonal quaternary quadratic forms representing one (see Table 1). In particular, we use eta-quotients to prove the strongly s-regularity of the quaternary quadratic form x 2`2 y 2`3 z 2`1 0w 2 , which is, in fact, of class number 2 (see Lemma 5.5 and Proposition 5.6).2010 Mathematics Subject Classification. Primary 11E12, 11E20, 11E45.