The number of the intraepithelial T cells correlate with the proliferation index in human bulbourethral gland epithelium

Боронихина, Т. В.; Piavchenko, Gennadii; Венедиктов, А. А.; Kustavinova, Ekaterina  V.; Mukhamedova, Svetlana; Kartashkina, N. L.; Кузнецов, С. Л.; Meglinski, Igor; Yatskovskiy, Alexander

doi:10.1016/j.heliyon.2022.e11658

Cited by 1 publication

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“…At least two alternatives to androgen-mediated stimulation of allometric growth have been suggested. In humans, T cells may stimulate the proliferation of cells in the bulbourethral glands [20]. The possibility exists that T cells might be involved in the initial allometric growth in control boars, although further investigation is beyond the scope of the current work.…”

Section: Discussionmentioning

confidence: 89%

Gene Expression in Porcine Bulbourethral Glands

Noto,

Nitta-Oda,

Berger

2024

Animals

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The porcine bulbourethral glands produce a gel-type secretion. Although the role of these contributions to reproductive success remains murky, the bulbourethral glands are major accessory sex glands in this species. Isometric growth in the early neonatal interval is followed by allometric growth in the late juvenile interval (6 to 11 weeks of age), while circulating endogenous steroids are low. The rate of allometric growth increases during the peripuberal interval (16 to 20 weeks of age) when systemic testosterone is relatively high. Gene expression for androgen receptor (AR) and for the steroid 5 alpha-reductase 2 (SRD5A2) enzyme that synthesizes the more potent androgen dihydrotestosterone from its precursor was evaluated by qPCR analyses of bulbourethral gland tissue. Tissues were collected from control boars (2 weeks to 40 weeks of age) and from littermates of these boars treated with letrozole to suppress endogenous estrogen synthesis. Gene expression for these two key proteins in androgen signaling was quite low during the initial allometric growth in the late juvenile and prepuberal intervals, suggesting that this initial growth was not primarily stimulated by androgens. These observations are consistent with a more direct estrogen-mediated inhibition of growth via GPER previously proposed, with the sensitivity extending into the late juvenile interval when estrogens as well as androgens are normally relatively low.

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Section: Discussionmentioning

confidence: 89%