2017
DOI: 10.1111/nmo.13046
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The nutrient‐sensing repertoires of mouse enterochromaffin cells differ between duodenum and colon

Abstract: We highlight the diversity of EC cell physiology and identify differences in the regional sensing repertoire of EC cells to an assortment of nutrients. These data indicate that not all EC cells are similar and that differences in their physiological responses are likely dependent on their location within the GI tract.

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Cited by 58 publications
(68 citation statements)
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“…In this issue of Neurogastroenterology and Motility, Martin et al . reveal remarkable differences in expression levels for nutrient receptor and transporter genes in highly enriched isolates of EC cells from mouse duodenum and colon.…”
Section: Heterogeneity Of 5‐ht Roles and Cell Typesmentioning
confidence: 99%
See 3 more Smart Citations
“…In this issue of Neurogastroenterology and Motility, Martin et al . reveal remarkable differences in expression levels for nutrient receptor and transporter genes in highly enriched isolates of EC cells from mouse duodenum and colon.…”
Section: Heterogeneity Of 5‐ht Roles and Cell Typesmentioning
confidence: 99%
“…The paper of Martin et al. in the current issue reveals free fatty acid receptor (FFAR) expression by duodenal EEC that contain 5‐HT . It is feasible that duodenal EC that express FFAR are the 5‐HT/CCK cells discussed above.…”
Section: Heterogeneity Of 5‐ht Roles and Cell Typesmentioning
confidence: 99%
See 2 more Smart Citations
“…Indeed, 5-HT cells in the duodenum exhibit a remarkably distinct repertoire of nutrient receptors compared to 5-HT cells in the colon (Martin et al 2017). Another study by this group compared functional responses in duodenal and colonic mouse 5-HT cells, and found that duodenal cells secreted more 5-HT in response to glucose than to fructose or sucrose, and that the opposite was true of colonic 5-HT cells (Martin et al 2017). Intraluminal glucose stimulated GLP-1 secretion from mouse upper small intestine but not from the colon (Moriya et al 2009).…”
Section: Species and Regional Differences In Eec Populationsmentioning
confidence: 99%