The Nutritional Intervention of Resveratrol Can Effectively Alleviate the Intestinal Inflammation Associated With Celiac Disease Induced by Wheat Gluten

Abstract

Background and AimsWheat gluten is a critical trigger for celiac disease, often causing inflammatory lesions and oxidative stress damage in the intestines of patients. In daily life, it is difficult for celiac disease patients to strictly avoid the dietary intake of gluten, which makes complementary preventive therapy particularly urgent. As such, we investigated the alleviating effects of resveratrol in vivo and in vitro models of celiac disease.MethodsWe established in vivo and in vitro models of gluten protein-induced celiac disease. The intervention effect of resveratrol was defined well based on relevant indicators of inflammation, immunity and oxidative stress, and its possible involvement in signaling pathways and genes were also identified.ResultsResveratrol was effective in reducing intestinal oxidative stress and inflammatory damage induced by wheat gluten in both cell and mouse models for celiac disease. We identified correlations between the genes (Fgf15, Nr0b2, Aire and Ubd) and signaling pathways (PPAR, AMPK and FoxO) in which resveratrol performed critical roles.ConclusionsResveratrol contributed to regulate development of autoimmunity through up-regulation of Aire and Ubd genes and promote nutrient absorption in intestine through down-regulation of Fgf15 and Nr0b2 genes, as well as played a role in regulating complex response system of oxidative stress, inflammatory response and immune response in intestine by activating PPAR, AMPK and FoxO signaling pathways, thus effectively alleviating the intestinal symptoms of celiac disease.

Dimethyl Fumarate and Intestine: From Main Suspect to Potential Ally against Gut Disorders

“…The protective role of Nrf2 was also demonstrated in the context of CeD. Particularly, wheat germ peptides exerted a beneficial role in an in vitro model of CeD through the activation of the Nrf2 pathway [ 113 ]; moreover, resveratrol, a well-known Nrf2 inducer, led to a reduction in oxidative stress and epithelial cell damage in in vitro and in vivo CeD models [ 114 ]. Similar results were also obtained in a gliadin-induced enteropathy mouse model using conjugated linoleic acid [ 115 ].…”

Prevalence of IgA Anti-tissue Transglutaminase Antibody in a Cohort of Iranians Patients with Inflammatory Bowel Disease

“…A possible explanation for this condition is silent celiac disease (CeD), which is about seven times more common than the classic type and its association with IBD has been reported in some cases. 5 Celiac disease occurs when the immune system reacts permanently to gluten. 6 CeD has now been recognized as a multisystem disease affecting various organs in genetically predisposed individuals.…”

“…A possible explanation for this condition is silent celiac disease (CeD), which is about seven times more common than the classic type and its association with IBD has been reported in some cases. 5…”