The nutritional roles of zinc for immune system and COVID-19 patients

Jin, Di; Wei, Xinran; He, Yunyi; Zhong, Luying; Lu, Huijie; Lan, Jiaxin; Wei, Yuting; Liu, Zheng; Liu, Hongbo

doi:10.3389/fnut.2024.1385591

Cited by 6 publications

(2 citation statements)

References 137 publications

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“…Deficiencies in essential proteins, vitamins, and minerals further weaken physical barriers and cellular immunity. This predisposition not only increases susceptibility to severe infections but also increases the risk of prolonged illness and complications [ 31 , 32 , 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

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Malnutrition and the Post-Acute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Multi-Institutional Population-Based Propensity Score-Matched Analysis

Lee,

Liang,

Hsu

et al. 2024

Life

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Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a global health crisis, exacerbating issues like malnutrition due to increased metabolic demands and reduced intake during illness. Malnutrition, a significant risk factor, is linked to worse outcomes in patients with COVID-19, such as increased mortality and extended hospital stays. This retrospective cohort study investigated the relationship between malnutrition and clinical outcomes within 90–180 days using data obtained from the TriNetX database. Patients aged >18 years diagnosed with COVID-19 between 1 January 2022, and 31 March 2024 were enrolled in the study. The propensity score-matching (PSM) method was used to match patients with malnutrition (malnutrition group) and those without malnutrition (control group). The primary composite outcome was the cumulative hazard ratio (HR) for post-COVID-19 condition, all-cause hospitalization, and all-cause mortality between 90 days and 180 days after COVID-19 diagnosis. The secondary outcomes were the individual components of the primary outcomes. Two cohorts, each consisting of 15,004 patients with balanced baseline characteristics, were identified using PSM. During the 90–180-day follow-up period, the malnutrition group exhibited a higher incidence of all-cause hospitalization, mortality, or post-COVID-19 condition (HR = 2.315, 95% confidence interval: 2.170–2.471, p < 0.0001). Compared with patients with COVID-19 without malnutrition, those with malnutrition may be associated with a higher risk of adverse clinical outcomes.

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Section: Discussionmentioning

confidence: 99%

“…It induces an imbalanced cytokine profile, promoting inflammatory pathways that can lead to the occurrence of cytokine storm syndrome, a known predictor of severe outcomes in COVID-19. Uncontrolled inflammation can result in tissue damage, multi-organ failure, and heightened mortality risk [ 32 , 35 , 36 , 37 , 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Malnutrition and the Post-Acute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Multi-Institutional Population-Based Propensity Score-Matched Analysis

Lee,

Liang,

Hsu

et al. 2024

Life

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Nanominerals Packaged in pH‐Responsive Alginate Microcapsules Exhibit Selective Delivery in Small Intestine and Enhanced Absorption and Bioavailability

Bhagat,

Singh

2024

Adv Funct Materials

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Mineral supplementation is crucial for human nutrition to facilitate appropriate growth, disease prevention, and improved reproductive health. The conventional forms of mineral supplementation involve an ionic form of elements mixed with biomolecules; however, suffer from unfavorable reactions under an acidic environment of stomach, ROS generation, and poor absorption in the small intestine. To address this, nanominerals (NMs) of six essential mineral elements are synthesized and packed in pH‐responsive microcapsule. Each NMs is coated with biomolecules that are known to rapidly absorb through the intestinal epithelium. Microcapsules are found intact at acidic pH (pH: 2.0–6.5); however, selectively release NMs at pH ≥7.0. The in vitro study demonstrates that the mixture of NMs and microcapsules is biocompatible and exhibits excellent ROS scavenging ability at physiological pH. Oral administration of NMs‐loaded microcapsules to rats shows enhanced levels of minerals, vitamin B12, hemoglobin, and total antioxidant activity in blood. The liver, kidneys, and spleen show enhanced expression of Cu/Zn‐SOD and Mn‐SOD enzymes due to high absorption and bioavailability of ZnO, Cu2O, and MnO2 NMs through the intestine. Thus, the pH‐responsive microcapsules hold promise to effectively stealth the encapsulated nutrient materials from the acidic environment of stomach and precisely deliver them to small intestine.

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Strategies and bibliometric analysis of legumes biofortification to address malnutrition

Altaf,

Liaqat,

Jamil

et al. 2024

Planta

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The nutritional roles of zinc for immune system and COVID-19 patients

Cited by 6 publications

References 137 publications

Malnutrition and the Post-Acute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Multi-Institutional Population-Based Propensity Score-Matched Analysis

Malnutrition and the Post-Acute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Multi-Institutional Population-Based Propensity Score-Matched Analysis

Nanominerals Packaged in pH‐Responsive Alginate Microcapsules Exhibit Selective Delivery in Small Intestine and Enhanced Absorption and Bioavailability

Strategies and bibliometric analysis of legumes biofortification to address malnutrition

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