The Nutritional Status of Chronic Obstructive Pulmonary Disease Exacerbators

Silvestre, Carina Rôlo; Domingues, Tiago Dias; Mateus, L.; Cavaco, M.J.; Nunes, André; Cordeiro, Ricardo José; Santos, Teresa Silva; Falcão, Teresa; Domingos, António

doi:10.1155/2022/3101486

Cited by 6 publications

(2 citation statements)

References 17 publications

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“…In this scenario, malnutrition plays a key role in COPD patients by reducing muscle mass and decreasing the strength and endurance of respiratory muscles. Furthermore, malnutrition is associated with the severity of the disease and is related to increased exacerbations, hospitalization, and prolonged hospital stays [27].…”

Section: Discussionmentioning

confidence: 99%

Controlling Nutritional Status Score as a Predictor for Chronic Obstructive Pulmonary Disease Exacerbation Risk in Elderly Patients

Lo Buglio,

Scioscia,

Bellanti

et al. 2023

Metabolites

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The Controlling Nutritional Status (CONUT) score is a simple screening tool able to assess poor nutritional status as well as to predict clinical adverse outcomes in different clinical settings. No data are available in older patients with chronic obstructive pulmonary disease (COPD). This study aimed to investigate the CONUT score as a predictor of frequent exacerbations. We retrospectively enrolled 222 patients aged 65 years or older, classified in two groups according to the number of exacerbations (or hospitalizations because AECOPD) during the previous year. The two groups were further divided according to low (<5) or high (≥5) CONUT scores. A total of 67.2% of frequent exacerbators had a high CONUT score. These patients exhibited a significantly higher CAT score, lower FEV1 percentage value, and higher prevalence of severe GOLD stages compared to those with low CONUT. Multivariate analysis showed that a CONUT score ≥ 5 was the best independent predictor (OR 20.740, p < 0.001) of the occurrence of ≥2 exacerbations (or 1 hospitalization) during the previous year. The CONUT score seemed to have a high prognostic value for frequent exacerbations for COPD in older patients. The predictive role of different CONUT score cut-off values needs to be validated in larger COPD populations in future multi-center, prospective clinical studies.

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Section: Discussionmentioning

confidence: 99%

Controlling Nutritional Status Score as a Predictor for Chronic Obstructive Pulmonary Disease Exacerbation Risk in Elderly Patients

Lo Buglio,

Scioscia,

Bellanti

et al. 2023

Metabolites

View full text Add to dashboard Cite

show abstract

“…5 Nutritionalrelated problems that are often encountered in COPD patients include malnutrition, sarcopenia and obesity. 6,7 Macronutrients, particularly carbohydrates, protein, and fat, play a significant role in COPD. 8,9 A poor macronutrient diet leads to an increased risk of COPD and declined lung function which relate to disease symptoms such as dyspnea, fatigue, anorexia, and weight loss.…”

Section: Introductionmentioning

confidence: 99%

The Role of Macronutrients in Chronic Obstructive Pulmonary Disease: A Review

Kristy,

Hardian,

Putra

et al. 2024

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The incidence of chronic obstructive pulmonary disease (COPD) is rising and is still regarded as one of the challenging medical issues. Regardless of the main relationship between tobacco smoking and toxic particle exposure with COPD, factors like nutritional status also play an important role in COPD progression and outcome, as the factor is an adaptable aspect. Malnutrition, sarcopenia, and obesity are nutritional problems that are often encountered in COPD patients. Macronutrients, namely carbohydrates, fat, and protein, support the adjunctive treatment options for COPD. The ideal dietary pattern includes low carbohydrates, medium fats preferably polyunsaturated fatty acids (PUFA), and high proteins to improve COPD symptoms, preserve muscle mass, and delay disease progression. High carbohydrate intake might also increase the respiratory quotient (RQ) which results in higher carbon dioxide (CO2) production and oxygen (O2) demand compared to fat and protein intake. Daily calorie intake should be adjusted to personal nutritional status. Higher calories in malnourished, sarcopenic patients and targeted weight loss in obese patients show improvements in lung function, frequency of exacerbations, and hospitalization rate. In obese individuals with COPD, however, maintaining a slightly higher body mass index (BMI) of 25-30 kg/m2 was associated with lower mortality. This literature review summarized the significant role of macronutrients in COPD patients and the practical approach to macronutrient intervention in individuals with different nutritional statuses.

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Malnutrition is associated with mortality in Sjögren’s syndrome-associated interstitial lung disease

Chung,

Woo,

Yong

et al. 2024

Sci Rep

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The role of nutritional status as a prognostic factor in patients with Sjögren’s syndrome-associated interstitial lung disease (SjS-ILD) is currently unclear. This study aimed to predict the prognosis of patients with SjS-ILD through their nutritional status assessment. In this retrospective observational study, nutritional status was evaluated at the time of diagnosis using body mass index (BMI) and nutritional markers such as controlling nutritional status (CONUT), the Glasgow prognostic score (GPS), and prognostic nutrition index (PNI) for all participants. Receiver operating characteristic (ROC) analyses were performed using BMI and each nutritional marker data to compare the area under the ROC curve (AUC) and find the cutoff value using the maximum Youden index. Kaplan–Meier analysis and Cox proportional hazards regression analysis were performed to predict the prognosis of SjS-ILD patients. A total of 112 SjS-ILD patients were enrolled in the study, and 8.9% died during the follow-up period. The median time from diagnosis to follow-up period was 4.2 years. The AUC for PNI was the highest among nutritional markers and BMI, and PNI cutoff value was used to distinguish between the PNI < 47.7 and PNI ≥ 47.7 groups. A statistical difference was observed in the Kaplan–Meier analysis and log-rank test ( p = 0.005). In multivariable analyses, PNI < 47.7 (hazard ratio 9.40, 95% confidence interval 1.54–57.21) is associated with increased mortality, suggesting the importance of early nutritional intervention for malnutrition in SjS-ILD patients.

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The Nutritional Status of Chronic Obstructive Pulmonary Disease Exacerbators

Cited by 6 publications

References 17 publications

Controlling Nutritional Status Score as a Predictor for Chronic Obstructive Pulmonary Disease Exacerbation Risk in Elderly Patients

Controlling Nutritional Status Score as a Predictor for Chronic Obstructive Pulmonary Disease Exacerbation Risk in Elderly Patients

The Role of Macronutrients in Chronic Obstructive Pulmonary Disease: A Review

Malnutrition is associated with mortality in Sjögren’s syndrome-associated interstitial lung disease

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