The nutritive and metabolic advantages of homologous milk

Casey, Clare E.

doi:10.1079/pns19890039

Cited by 7 publications

(4 citation statements)

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“…The only foods that had a significant effect were rat milk and colostrum, which both led to a higher level of UCP mRNA being present. Principally, this positive effect is in accordance with the idea that homologous milk is best for the development of the pups [39].…”

Section: Does Colostrum Contain An Inhibitory Factor For Lpl Gene Expsupporting

confidence: 84%

Postnatal selective suppression of lipoprotein lipase gene expression in brown adipose tissue (relative to the expression of the gene for the uncoupling protein) is not due to adrenergic insensitivity: a possible specific inhibitory effect of colostrum

Obregón

Cannon

Nedergaard

1996

Biochemical Journal

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The levels of mRNA coding for the uncoupling protein (UCP) and for lipoprotein lipase (LPL) were monitored in the brown adipose tissue of newborn rat pups. At 5 h after birth, the mRNA levels of UCP and LPL were high in pups exposed singly to 28 degrees C and low in pups kept singly at thermoneutrality (36 degrees C); in pups staying with the dam, the UCP mRNA levels were intermediate. However, the LPL mRNA levels were lower in pups staying with the dam than in pups at 36 degrees C, implying that factors additional to environmental temperature influenced LPL gene expression. Injection of noradrenaline into pups at thermoneutrality (36 degrees C) led to increases in UCP and LPL gene expression, but noradrenaline injections had no further effect in cold-exposed pups. The adrenergic effects were mediated via beta-adrenergic receptors. The cold-induced increases in both UCP and LPL gene expression were abolished by the beta-adrenergic antagonist propranolol. Thus differences in adrenergic responsiveness could not explain the differential expression of the UCP and LPL genes observed in pups staying with the dam. The presence of a physiological suppressor was examined by feeding single pups at 28 degrees C with different foods: nothing, water, Intralipid, cow's milk, rat milk and rat colostrum. None of these agents led to suppression of UCP gene expression, but colostrum led to a selective suppression of LPL gene expression. It was concluded that the genes for UCP and LPL were responsive to adrenergic stimuli immediately after birth, and it is suggested that a component of rat colostrum can selectively suppress LPL gene expression.

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Section: Does Colostrum Contain An Inhibitory Factor For Lpl Gene Expsupporting

confidence: 84%

Postnatal selective suppression of lipoprotein lipase gene expression in brown adipose tissue (relative to the expression of the gene for the uncoupling protein) is not due to adrenergic insensitivity: a possible specific inhibitory effect of colostrum

Obregón

Cannon

Nedergaard

1996

Biochemical Journal

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“…In addition, the 21-months old infant was not exclusively breastfed. Human milk volume and composition in this setting and period of lactation also differs from mature milk during exclusive breastfeeding ( Casey, 1989 ). During the first days postpartum, the immature blood-milk barrier might result in higher concentrations of medicines in colostrum ( Nguyen and Neville, 1998 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Bosentan and Sildenafil Exposure in Human Milk - A Contribution From the ConcePTION Project

Nauwelaerts

Ceulemans²,

Deferm³

et al. 2022

Front. Pharmacol.

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Introduction: Quantitative information on disposition of maternal medicines in human milk remains a major knowledge gap. This case report presents the clinical and pharmacokinetic data of a single mother-infant pair exposed to bosentan and sildenafil for the treatment of pulmonary arterial hypertension (PAH) during lactation.Case presentation: A 43-year old mother was treated with sildenafil (20 mg, 3x/day) and bosentan (125 mg, 2x/day) for PAH. Her 21-months old infant received breastfeeding in combination with adequate complementary foods. Milk samples were collected over 24 h, at day 637 and 651 after delivery. The observed average steady-state concentrations of sildenafil (2.84 μg/L) and bosentan (49.0 μg/L) in human milk were low. The Daily Infant Dosage ingested by the nursing infant through human milk was 0.02 μg/kg/day for sildenafil and 0.29 μg/kg/day for bosentan at day 637, and 0.03 μg/kg/day and 0.60 μg/kg/day at day 651. The Relative Infant Dose calculated for an exclusively breastfed infant with an estimated milk intake of 150 ml/kg/day, was 0.06% for sildenafil and 0.24% for bosentan. General health outcome of the infant, reported by the mother, was uneventful until the sampling days.Conclusion: Low medicine concentrations were found in human milk expressed 21 months after delivery after maternal intake of 20 mg sildenafil three times daily and 125 mg bosentan twice daily. General health of the nursing infant until sampling was reported as optimal by the mother.

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“…U svih životinjskih vrsta na sastav mlijeka najviše utječe stadij laktacije, jer su najznačajnije razlike između kolostruma i mlijeka nakon kolostruma (Casey, 1989.). Ubrzo nakon partusa stvara se kolostrum koji je bogat suhom tvari, proteinima, mastima, vitaminima i mineralima, a siromašniji laktozom od mlijeka.…”

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Prehrambene specifičnosti proteina i masti u kobiljem mlijeku u odnosu na humano i kravlje mlijeko

et al. 2021

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Zadnjih se desetljeća kobilje mlijeko istražuje kao funkcionalna i ljekovita hrana. Sastav kobiljeg, humanog i kravljeg mlijeka znatno se razlikuje, a varira i o genetskim, fiziološkim i prehrambenim čimbenicima, kao i o uvjetima okoliša. Uspoređujući ga s humanim i kravljim mlijekom, kobilje mlijeko ima nižu energetsku vrijednost i niže vrijednosti masti. Sadržaj proteina sirutke i kazeina u kobiljem mlijeku sličan je onom u humanom za prehranu ljudi i čini ga pogodnijim od kravljega. Kobilje i humano mlijeko formiraju precipitat koji je lakše probavljiv od koaguluma kravljeg mlijeka. Vanjska membrana masnih globula, kao i raspodjela di- i tri- glicerida iz kobiljeg i humanog mlijeka su slične. Postotak nezasićenih masnih kiselina u kobiljem i humanom mlijeku veći je nego u kravljem mlijeku, a najveći dio otpada na polinezasićene masne kiseline sa srednjim i većim brojem ugljikovih atoma. Kobilje mlijeko zauzima sve više prostora u nutricionizmu zbog svojih specifičnih kemijskih i nutritivnih karakteristika.

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The nutritive and metabolic advantages of homologous milk

Cited by 7 publications

References 57 publications

Postnatal selective suppression of lipoprotein lipase gene expression in brown adipose tissue (relative to the expression of the gene for the uncoupling protein) is not due to adrenergic insensitivity: a possible specific inhibitory effect of colostrum

Postnatal selective suppression of lipoprotein lipase gene expression in brown adipose tissue (relative to the expression of the gene for the uncoupling protein) is not due to adrenergic insensitivity: a possible specific inhibitory effect of colostrum

Case Report: Bosentan and Sildenafil Exposure in Human Milk - A Contribution From the ConcePTION Project

Prehrambene specifičnosti proteina i masti u kobiljem mlijeku u odnosu na humano i kravlje mlijeko

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