The Nuts and Bolts of Low-level Laser (Light) Therapy

Chung, Hoon; Dai, Tianhong; Sharma, Sunil; Huang, Ying‐Ying; Carroll, James D.; Hamblin, Michael R.

doi:10.1007/s10439-011-0454-7

Cited by 1,242 publications

(1,096 citation statements)

References 112 publications

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“…In contrast, LLLT keeps the cellular reaction below this threshold and thereby it can modulate the activity of the target cells. Therefore, LLLT is a therapeutic modality [4,8,9].…”

Section: Llt-mechanism Of Action On Molecular Levelmentioning

confidence: 99%

“…These processes will increase the cellular activity and improve the intracellular signal transmission pathways. This will eventually lead to the synthesis of DNA and RNA, enzymes, and proteins, resulting in an enhanced cell proliferation, cell activation, and repair of injured/ compromised cells [4,7,8].…”

Section: Llt-mechanism Of Action On Molecular Levelmentioning

confidence: 99%

“…NO is known to cause vasodilatation by triggering the relaxation of smooth muscle associated with endothelium. This vasodilation increases the availability of oxygen to exposed cells and also allows for greater traffic of immune cells into tissue [8,12].…”

Section: Llt-mechanism Of Action On Molecular Levelmentioning

confidence: 99%

“…Appropriate LLLT parameters seem to be crucial in the effectiveness of this treatment method in the described disorders [8].…”

Section: Laser Parametersmentioning

confidence: 99%

“…It is a noninvasive treatment option used to stimulate wound healing and reduce inflammation, edema, and pain. LLLT is applied in a variety of medical domains ranging from dermatology, physiotherapy, neurology, to dentistry [4][5][6][7][8]. The use of LLLT in an oncologic setting has become an interesting study object in the recent years.…”

Section: Introductionmentioning

confidence: 99%

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The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

et al. 2016

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Breast cancer is the most common cancer in women worldwide, with an incidence of 1.7 million in 2012. Breast cancer and its treatments can bring along serious side effects such as fatigue, skin toxicity, lymphedema, pain, nausea, etc. These can substantially affect the patients' quality of life. Therefore, supportive care for breast cancer patients is an essential mainstay in the treatment. Low-level light therapy (LLLT) also named photobiomodulation therapy (PBMT) has proven its efficiency in general medicine for already more than 40 years. It is a noninvasive treatment option used to stimulate wound healing and reduce inflammation, edema, and pain. LLLT is used in different medical settings ranging from dermatology, physiotherapy, and neurology to dentistry. Since the last twenty years, LLLT is becoming a new treatment modality in supportive care for breast cancer. For this review, all existing literature concerning the use of LLLT for breast cancer was used to provide evidence in the following domains: oral mucositis (OM), radiodermatitis (RD), lymphedema, chemotherapy-induced peripheral neuropathy (CIPN), and osteonecrosis of the jaw (ONJ). The findings of this review suggest that LLLT is a promising option for the management of breast cancer treatment-related side effects. However, it still remains important to define appropriate treatment and irradiation parameters for each condition in order to ensure the effectiveness of LLLT.

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“…In contrast, LLLT keeps the cellular reaction below this threshold and thereby it can modulate the activity of the target cells. Therefore, LLLT is a therapeutic modality [4,8,9].…”

Section: Llt-mechanism Of Action On Molecular Levelmentioning

confidence: 99%

Section: Llt-mechanism Of Action On Molecular Levelmentioning

confidence: 99%

Section: Llt-mechanism Of Action On Molecular Levelmentioning

confidence: 99%

“…Appropriate LLLT parameters seem to be crucial in the effectiveness of this treatment method in the described disorders [8].…”

Section: Laser Parametersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

et al. 2016

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Acupuncture for depression

Smith

Armour

Lee

et al. 2018

Cochrane Database of Systematic Reviews

156

155

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The reduction in severity of depression was less when acupuncture was compared with control acupuncture than when acupuncture was compared with no treatment control, although in both cases, results were rated as providing low-quality evidence. The reduction in severity of depression with acupuncture given alone or in conjunction with medication versus medication alone is uncertain owing to the very low quality of evidence. The effect of acupuncture compared with psychological therapy is unclear. The risk of adverse events with acupuncture is also unclear, as most trials did not report adverse events adequately. Few studies included follow-up periods or assessed important outcomes such as quality of life. High-quality randomised controlled trials are urgently needed to examine the clinical efficacy and acceptability of acupuncture, as well as its effectiveness, compared with acupuncture controls, medication, or psychological therapies.

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