The Obesity Paradox in Patients With Peripheral Arterial Disease

Body Composition and Survival in Stable Coronary Heart Disease

“…In addition, including COPD in our multivariable model did not change the influence of BF on mortality risk, although it weakened the relationship of LMI. Even in patients with peripheral arterial disease, in whom smoking and COPD are prevalent and strongly associated with this disease, COPD did not completely explain the obesity paradox (14,16). A recent study of more than 50,000 patients with ST-segment elevation myocardial infarction showed that the highest in-hospital mortality was in the "normal" BMI group, followed closely by the class 3 obese or severely obese patients.…”

Impact of weight on long-term survival among patients without known coronary artery disease and a normal stress SPECT MPI

“…[1][2][3][4][5][6][7][8][9][10][11] However, among patients with known cardiac disease, various studies have found a lower rate for adverse events among patients with increasing BMI, such as patients with heart failure, 16,17,21 patients undergoing percutaneous intervention, 15,18,19 patients with hypertension, 29 and peripheral arterial disease. 24 However, how weight impacts prognosis among patients without known CAD and a normal SPECT MPI is not well documented. In this study, we found that the obesity paradox extends to patients in whom functionally significant CAD has been excluded by cardiac testing, as determined by stress-rest myocardial perfusion imaging.…”

“…[1][2][3][4][5][6][7][8][9][10][11][12] The increased risk of obesity for cardiovascular disease is thought to be mediated in part by a pro-inflammatory state and increased prevalence of coronary artery disease (CAD) risk factors such as hypertension, hypercholesterolemia, and diabetes mellitus. 13,14 However, among patients with known cardiac disease, [15][16][17][18][19][20][21][22][23][24][25] body mass index (BMI), the most commonly employed measurement to categorize weight, has correlated poorly with cardiac outcomes, 26,27 and in a large meta-analysis, a BMI of 25-29.9 kg Á m 2 was associated with a 13% reduction for mortality. 22 This phenomenon has been termed the ''obesity paradox''.…”

The Obesity Paradox and Cardiovascular Disease

“…Galal et al [12] reviewed 2392 patients who underwent major vascular surgery for peripheral arterial disease (PAD) and were at high risk for mortality during the follow-up period. At a mean follow-up of 4.37 years, they reported significantly better survival among the patients in the normal-BMI, overweight, and obese quartiles compared with an underweight quartile of patients.…”