2019
DOI: 10.1016/s2213-8587(19)30026-9
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The obesity transition: stages of the global epidemic

Abstract: Our aim was to consolidate the evidence on the epidemiology of obesity into a conceptual model of the 'obesity transition'. Illustrative examples from the thirty most populous countries, representing 77•5% of the world's population, were used. Stage 1 of the obesity transition is characterised by a higher prevalence in women compared to men, in those with higher compared to lower socioeconomic status, and adults compared to children. Many countries in South Asia and sub-Saharan Africa are at this stage. In Sta… Show more

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Cited by 875 publications
(716 citation statements)
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“…Insulin resistance has long been viewed as the primary cause of the disease, whereas β‐cell failure has been considered its consequence, reflecting β‐cell “exhaustion” in an effort to overcome insulin resistance by a continuous increase in insulin production. Given that insulin resistance is a hallmark of obesity, the rise in T2D incidence has been largely attributed to the obesity epidemic . In obese people, hyperlipidemia impairs metabolism and function of multiple cell types in a number of ways, including reducing cell sensitivity to insulin .…”
Section: Beta‐cell Failure In Type 2 Diabetesmentioning
confidence: 99%
“…Insulin resistance has long been viewed as the primary cause of the disease, whereas β‐cell failure has been considered its consequence, reflecting β‐cell “exhaustion” in an effort to overcome insulin resistance by a continuous increase in insulin production. Given that insulin resistance is a hallmark of obesity, the rise in T2D incidence has been largely attributed to the obesity epidemic . In obese people, hyperlipidemia impairs metabolism and function of multiple cell types in a number of ways, including reducing cell sensitivity to insulin .…”
Section: Beta‐cell Failure In Type 2 Diabetesmentioning
confidence: 99%
“…In recent decades, the worldwide prevalence of cardiovascular and chronic non-communicable metabolic disease has dramatically increased among young, middle-aged and elderly adults [1,2]. Metabolic syndrome, obesity and type II diabetes mellitus all strongly increase the risk of cardiovascular disease [3].…”
Section: Introductionmentioning
confidence: 99%
“…[ 1 ] The global prevalence of obesity has increased dramatically over the past several decades among children as well as adults; from <1% in 1975 to 6–8% in 2016, among children, and from 3–6% to 11–15% among adults over the same time period. [ 2 ] As obesity is a major risk factor for type 2 diabetes (T2D), paralleling the increasing trend of obesity, the worldwide prevalence of T2D is estimated to reach 7.7% in 2030, affecting 439 million adults. [ 3 ]…”
Section: Introductionmentioning
confidence: 99%