The Object Space Task reveals increased expression of cumulative memory in a mouse model of Kleefstra syndrome

Schut, Evelien H. S.; Alonso, Alejandra; Smits, Steven; Khamassi, Mehdi; Samanta, Anumita; Negwer, Moritz; Kasri, Nael Nadif; Navarro‐Lobato, Irene

doi:10.1016/j.nlm.2020.107265

Cited by 6 publications

(3 citation statements)

References 36 publications

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“…The first week of training Ehmt1 +/- mice were exploring less than WT animals. As weeks went by, exploration time increased in Ehmt1 +/- mice, reaching the same values as WTs (Schut et al, 2020), similar to what we report in this study. Ehmt1 +/- hosts decrease the time they spent interacting after experiencing the task for a third time, reaching similar values to WTs.…”

Section: Discussionsupporting

confidence: 90%

“…Deficits in fear extinction learning, novel object recognition and spatial object recognition have been reported in single-trial experiments (Balemans et al, 2010). However, in spatial learning studies involving multi-trial experiences and in pattern separation assays, Ehmt1 +/- mice can outperform WTs (Benevento et al, 2017; Schut et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Defensive and offensive behaviors in social interaction settings in a Kleefstra syndrome mouse model

Alonso

Samanta

Meij

et al. 2022

Preprint

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Kleefstra syndrome in humans is characterized by general delay in development, intellectual disability and autistic features. The mouse model of this disease (Ehmt1+/-) expresses anxiety, autistic-like traits, and aberrant social interactions with non-cagemates. To investigate how Ehmt1+/- mice behave with unfamiliar conspecifics, we allowed adult, male animals to freely interact for 10 minutes in a neutral, novel environment within a host-visitor setting. In 17 out of 74 trials there were defensive and offensive behaviors. Our key finding was that Ehmt1+/- mice displayed defensive postures, attacking and biting; in contrast, wild-type (WT) interacting with other WT did not enact such behaviors. Further, if there was a fight between an Ehmt1+/- and a WT mouse, it was always the Ehmt1+/- who initiated these behaviors.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Defensive and offensive behaviors in social interaction settings in a Kleefstra syndrome mouse model

Alonso

Samanta

Meij

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Deficits in fear extinction learning, novel object recognition and spatial object recognition have been reported in singletrial experiments (Balemans et al 2010a). However, in spatial learning studies involving multi-trial experiences and in pattern separation assays, Ehmt1 ± mice can outperform WTs (Benevento et al 2017;Schut et al 2020). At the neuronal network level, these mice suffer from hippocampal synaptic dysfunctions, reduced dendritic branching and spine density (Balemans et al 2010a;Balemans et al 2014), delay in maturation of parvalbumin GABAergic interneurons in sensory cortical areas (Negwer et al 2020), and irregular cortical network bursting patterns (Martens Frega et al 2016), all of which could lead to disabilities in learning and in executive functions such as short term memory and social behaviour.…”

Section: Introductionmentioning

confidence: 99%

Defensive and offensive behaviours in a Kleefstra syndrome mouse model

et al. 2023

Self Cite

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Kleefstra syndrome in humans is characterized by a general delay in development, intellectual disability and autistic features. The mouse model of this disease (Ehmt1±) expresses anxiety, autistic-like traits, and aberrant social interactions with non-cagemates. To investigate how Ehmt1± mice behave with unfamiliar conspecifics, we allowed adult, male animals to freely interact for 10 min in a neutral, novel environment within a host-visitor setting. In trials where the Ehmt1± mice were hosts, there were defensive and offensive behaviors. Our key finding was that Ehmt1± mice displayed defensive postures, attacking and biting; in contrast, wild-type (WT) interacting with other WT did not enact such behaviors. Further, if there was a fight between an Ehmt1± and a WT mouse, the Ehmt1± animal was the most aggressive and always initiated these behaviors.

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