The occurrence and accumulation of d-pinitol in fenugreek (Trigonella foenum graecum L.)

Lahuta, Leśław B.; Szablińska, Joanna; Ciak, M. J.; Górecki, Ryszard J.

doi:10.1007/s11738-018-2734-4

Cited by 14 publications

(7 citation statements)

References 79 publications

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“…Baquer et al [39] used fenugreek seed powder orally in rats and confirmed the effect of blood glucose normalization, almost comparable to that of insulin. Fenugreek is a source of DP [52]. After the addition of small traces of metals, additive effects of vanadium were found, while manganese showed additive effects with insulin in vitro in animals with diabetes.…”

Section: Cyclitols Insulin Resistance and Diabetesmentioning

confidence: 99%

“…In fenugreek leaves, stems, pods and seeds d -pinitol is a major cyclitol, representing 43–94% of total cyclitols and 2–77% of total soluble carbohydrates. In dry mature seeds, both the free d -pinitol and its α- d -galactosides (mono-, di- and tri-galactosyl pinitol A) occur at the concentration 0.4–0.6% of dry mass [52].…”

Section: Cyclitols Insulin Resistance and Diabetesmentioning

confidence: 99%

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The Healing-Promoting Properties of Selected Cyclitols—A Review

et al. 2018

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Introduction: Myo-inositol and its derivatives cyclitols play an important role in the processes of cell regulation, signal transduction, osmoregulation, and ion channel physiology, and are a component of the cell membrane. Free cyclitols present in food or released during the degradation of galactosyl cyclitols by bacteria (in digestive tract) show some physiological benefits. Aim: The aim of this paper is to present and analyze the documented data about curative and healing properties of cyclitols. Results and discussion: Cyclitols are well known compounds in the treatment of an accompanied diabetes insulin resistance, and also obesity and polycystic ovarian syndrome. d-chiro-Inositol deficiency exacerbates insulin resistance in the liver, muscles, and fat, while depletion of myo-inositol results in the development of diabetic complications. Cyclitols are successfully applied in treatment of polycystic ovarian syndrome, simultaneous are observed effective reducing of BMI, improving the hormonal profile, and increasing fertility. Moreover, cyclitols have anti-atherogenic, anti-oxidative, anti-inflammatory, and anti-cancer properties. Conclusion: The properties of cyclitols may be a good therapeutic option in the reduction of metabolically induced inflammation. Due to well drugs tolerance and low toxicity of these compounds, cyclitols are recommend for pregnant women and also for children. Another advantage is their widespread presence and easy availability, which encourages their use in medicine.

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Section: Cyclitols Insulin Resistance and Diabetesmentioning

confidence: 99%

Section: Cyclitols Insulin Resistance and Diabetesmentioning

confidence: 99%

The Healing-Promoting Properties of Selected Cyclitols—A Review

et al. 2018

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“…On the other hand, the major detected carbohydrates were sugar alcohols (close to 2%), followed by sucrose and other disaccharides. Despite most of these carbohydrates could not be clearly identified by the used analytical procedure, very recently, Lahuta et al [ 34 ] found that the most abundant sugar alcohols in fenugreek seeds were d -pinitol and α- d -galactosides of d -pinitol, as well as galactosides of myo -inositol.…”

Section: Resultsmentioning

confidence: 99%

Chemical Characterization and Bioaccessibility of Bioactive Compounds from Saponin-Rich Extracts and Their Acid-Hydrolysates Obtained from Fenugreek and Quinoa

Hierro

Reglero

Martín

2020

Foods

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Saponin-rich extracts from edible seeds have gained increasing interest and their hydrolysis to sapogenin-rich extracts may be an effective strategy to enhance their potential bioactivity. However, it remains necessary to study the resulting chemical modifications of the extracts after hydrolysis as well as their impact on the subsequent bioaccessibility of bioactive compounds. The chemical composition of non-hydrolyzed and hydrolyzed extracts from fenugreek (FE, HFE) and quinoa (QE, HQE), and the bioaccessibility of saponins, sapogenins and other bioactive compounds after an in vitro gastrointestinal digestion was assessed. In general, FE mainly contained saponins (31%), amino acids (6%) and glycerides (5.9%), followed by carbohydrates (3.4%), fatty acids (FFA) (2.3%), phytosterols (0.8%), tocols (0.1%) and phenolics (0.05%). HFE consisted of FFA (35%), sapogenins (8%) and partial glycerides (7%), and were richer in phytosterols (1.9%) and tocols (0.3%). QE mainly contained glycerides (33%), FFA (19%), carbohydrates (16%) and saponins (7.9%), and to a lesser extent alkylresorcinols (1.8%), phytosterols (1.5%), amino acids (1.1%), tocols (0.5%) and phenolics (0.5%). HQE mainly consisted of FFA (57%), partial glycerides (23%) and sapogenins (5.4%), were richer in phytosterols (2.4%), phenolics (1.2%) and tocols (0.7%) but poorer in alkylresorcinols (1%). After in vitro digestion, saponins from FE and QE were fully bioaccessible, sapogenins from HFE displayed a good bioaccessibility (76%) and the sapogenin from HQE was moderately bioaccesible (38%). Digestion of saponin and sapogenin standards suggested that other components of the extracts were enhancing the bioaccessibility. Other minor bioactive compounds (phytosterols, alkylresorcinols, tocols and some phenolics) also displayed optimal bioaccessibility values (70–100%).

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“…This high to low concentration gradient, also observed in other plant taxa by both Streeter [17] and Ford [7], may point to the translocation of d -pinitol to the upper plant nodes in order to maintain metabolism in the younger, expanding leaves. In contrast to fenugreek [18], d -pinitol accumulation seemed to follow spatial (high to low) distribution which was not dependent on plant organs, as stem and bottom leaf samples had very comparable d -pinitol concentrations. Notable concentration gradients coupled with spatial differences in gene expression further emphasize the complexity of d -pinitol accumulation and demonstrate the necessity of future studies to be conducted on a whole plant basis in order to fully understand the adaptive process that plants undergo in response to osmotic stress.…”

Section: Discussionmentioning

confidence: 99%

“…d -Pinitol concentrations were found to be highest in upper leaf nodes and were observed to decrease over time in agreement with Ford [7] who also noted d -pinitol accumulated to higher concentrations in younger, more recently expanded leaves located at the top of the plant. More recently, d -pinitol concentration has been observed to vary spatially between different plant organs of fenugreek ( Trigonella foenum graecum L. ) [18].…”

Section: Introductionmentioning

confidence: 99%

Water Deficit Elicits a Transcriptional Response of Genes Governing d-pinitol Biosynthesis in Soybean (Glycine max)

Dumschott

Dechorgnat

Merchant

2019

IJMS

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d-pinitol is the most commonly accumulated sugar alcohol in the Leguminosae family and has been observed to increase significantly in response to abiotic stress. While previous studies have identified genes involved in d-pinitol synthesis, no study has investigated transcript expression in planta. The present study quantified the expression of several genes involved in d-pinitol synthesis in different plant tissues and investigated the accumulation of d-pinitol, myo-inositol and other metabolites in response to a progressive soil drought in soybean (Glycine max). Expression of myo-inositol 1-phosphate synthase (INPS), the gene responsible for the conversion of glucose-6-phosphate to myo-inositol-1-phosphate, was significantly up regulated in response to a water deficit for the first two sampling weeks. Expression of myo-inositol O-methyl transferase (IMT1), the gene responsible for the conversion of myo-inositol into d-ononitol was only up regulated in stems at sampling week 3. Assessment of metabolites showed significant changes in their concentration in leaves and stems. d-Pinitol concentration was significantly higher in all organs sampled from water deficit plants for all three sampling weeks. In contrast, myo-inositol, had significantly lower concentrations in leaf samples despite up regulation of INPS suggesting the transcriptionally regulated flux of carbon through the myo-inositol pool is important during water deficit.

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The occurrence and accumulation of d-pinitol in fenugreek (Trigonella foenum graecum L.)

Cited by 14 publications

References 79 publications

The Healing-Promoting Properties of Selected Cyclitols—A Review

The Healing-Promoting Properties of Selected Cyclitols—A Review

Chemical Characterization and Bioaccessibility of Bioactive Compounds from Saponin-Rich Extracts and Their Acid-Hydrolysates Obtained from Fenugreek and Quinoa

Water Deficit Elicits a Transcriptional Response of Genes Governing d-pinitol Biosynthesis in Soybean (Glycine max)

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