The occurrence and pattern of ameloblastoma in children and adolescents: an Indian institutional study of 41 years and review of the literature

Bansal, Sumit; Desai, Rajiv S.; Shirsat, Pankaj M; Prasad, Priyanka; Karjodkar, Freny; Andrade, Neelam N.

doi:10.1016/j.ijom.2015.01.002

Cited by 48 publications

(48 citation statements)

References 20 publications

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“…Unicystic ameloblastoma is the second most common ameloblastoma and accounts for about 5–15% of all cases (Dhanuthai et al , ). It is most often seen in younger patients with average age of 26.1 years, and its main location is the posterior mandible where it often presents as an asymptomatic swelling (Bansal et al , ). The majority of unicystic ameloblastomas resemble dentigerous cyst because of their association with an unerupted tooth.…”

Section: Advances In Histopathogenesis Of Ameloblastomamentioning

confidence: 99%

“…Most patients with ameloblastoma are between ages 30 and 60 years, but average age at time of diagnosis varies from continent to continent estimated to be approximately 42.3 and 30.4 years in Europe and Africa, respectively (Olusanya et al , ; Oomens and van der Waal, ). Only 10–15% of ameloblastoma cases occur in the pediatric population, but this can be as high as 25% in Africa and Asia (Bansal et al , ).…”

Section: Introductionmentioning

confidence: 99%

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Ameloblastoma: current etiopathological concepts and management

et al. 2017

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Ameloblastoma is a benign odontogenic tumor of epithelial origin. It is locally aggressive with unlimited growth capacity and has a high potential for malignant transformation as well as metastasis. Ameloblastoma has no established preventive measures although majority of patients are between ages 30 and 60 years. Molecular and genetic factors that promote oncogenic transformation of odontogenic epithelium to ameloblastoma are strongly linked to dysregulation of multiple genes associated with mitogen-activated protein kinase, sonic hedgehog, and WNT/b-catenin signaling pathways. Treatment of ameloblastoma is focused on surgical resection with a wide margin of normal tissue because of its high propensity for locoregional invasion; but this is often associated with significant patient morbidity. The relatively high recurrence rate of ameloblastoma is influenced by the type of molecular etiological factors, the management approach, and how early the patient presents for treatment. It is expected that further elucidation of molecular factors that orchestrate pathogenesis and recurrence of ameloblastoma will lead to new diagnostic markers and targeted drug therapies for ameloblastoma. Oral Diseases (2018) 24, 307-316

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Section: Advances In Histopathogenesis Of Ameloblastomamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ameloblastoma: current etiopathological concepts and management

et al. 2017

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“…This result is relatively high for a benign tumor. Unfortunately, we are not currently able to predict either recurrences or the development of malignant ameloblastoma (11,12). …”

Section: Introductionmentioning

confidence: 99%

Recurrence and cancerization of ameloblastoma: multivariate analysis of 87 recurrent craniofacial ameloblastoma to assess risk factors associated with early recurrence and secondary ameloblastic carcinoma

Yang

Liu

Gokavarapu

et al. 2017

Chinese Journal of Cancer Research

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ObjectiveThe recurrence and progression of ameloblastoma are unpredictable. Therefore, we examined the influence of clinical factors on recurrence time and analyzed the clinical factors associated with early recurrence and cancerization. We then developed a staging system to predict early recurrence and cancerization.MethodsAll of the primary craniofacial ameloblastoma patients treated in Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine were recorded. There were 87 recurrent cases used to create a staging system and tested in a Cox regression analysis for risk factors associated with early recurrence or cancerization following surgery.ResultsThere were 890 craniofacial ameloblastoma patients, and 72 cases had recurrence. There were also 15 cases with cancerous recurrence. The overall recurrence rate was 9.78%, and the cancer rate was 1.69%. The primary cases were classified into the following 3 stages based on clinicopathological features: stage I, the maximum tumor diameter ≤6 cm; stage II, the maximum diameter of tumor >6 cm or tumor invasion to the maxilla sinus/orbital floor/soft tissue; and stage III, tumor invasion of the skull base or metastasis into regional lymph nodes. When the method of surgery was controlled by partial correlation, the staging had significance with recurrence time (P=0.004). The Cox analysis showed the tumor stage was correlated with recurrence time (P=0.027) and cancerization time (P=0.002). However, the surgical method did not influence the recurrence time when adjusted for cofounding variables.ConclusionsTumor larger than 6 cm and invasion to soft tissues or adjacent anatomical structures are associated with early recurrence. This staging system can be used to predict the risk factors of early recurrence and cancerization in ameloblastoma patients.

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“…Although wide variation exists, most of the large series studies have reported a prevalence of ameloblastoma among children and adolescents approximately 6%-20% in comparison to the general population. The mean age at presentation is between 13 and 15 year old [6][7][8][9][10][11][12][13][14] . The exact figure of occurrence is rather difficult to determine as these studies and reviews show variation in the upper age limit of the study population.…”

Section: Introductionmentioning

confidence: 99%

Basal cell ameloblastoma in a paediatric patient: a case report and review of oral basal cell tumours

2019

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Basal cell ameloblastoma (BCA) is a rare histological variant of ameloblastoma. It is composed of densely packed nests and strands of basaloid cells with inconspicuous stellate reticulum‐like cells. To date, there are only 24 reported cases of BCA in the English language literature. Ameloblastoma in children is relatively an uncommon tumour and accounts for approximately 15% among all odontogenic tumours. We report a case of BCA in an 8‐year‐old Iban girl who underwent hemimandibulectomy and reconstruction of the mandible with costochondral graft (CCG). A 6 months review showed that healing process was uneventful. She is under regular follow‐up and monitoring since multicystic ameloblastoma tend to recur and also the growth of the CCG is extremely unpredictable.

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The occurrence and pattern of ameloblastoma in children and adolescents: an Indian institutional study of 41 years and review of the literature

Cited by 48 publications

References 20 publications

Ameloblastoma: current etiopathological concepts and management

Ameloblastoma: current etiopathological concepts and management

Recurrence and cancerization of ameloblastoma: multivariate analysis of 87 recurrent craniofacial ameloblastoma to assess risk factors associated with early recurrence and secondary ameloblastic carcinoma

Basal cell ameloblastoma in a paediatric patient: a case report and review of oral basal cell tumours

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