The occurrence, causes, and consequences of estrogens in the aquatic environment

Sumpter, John P.; Jobling, Susan

doi:10.1002/etc.2084

Cited by 95 publications

(56 citation statements)

References 27 publications

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“…Many of these chemicals are released into the aquatic environment and include compounds that can interfere with sex steroid action with the potential to feminize or (de)masculinize organisms. Chemical contaminants with estrogen receptor agonist or androgen receptor antagonist activity are present in wastewater effluents (Hill et al, 2010;Sumpter and Jobling, 2013) and studies to date have indicated that the steroidal estrogens and possibly anti-androgens present in the receiving waters are causing the high levels of feminized fish present in some UK river sites (Jobling et al, 2006(Jobling et al, , 2009. Other EDCs such as organotins, which in the past were used in marine antifouling paints, have caused widespread masculinization of female gastropods and may act as ligands for different nuclear receptors involved in sexual differentiation rather than those for sex steroids (Pascoal et al, 2013;Titley-O'Neal et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds

Álvarez-Muñoz

Indiveri

Rostkowski

et al. 2015

Marine Pollution Bulletin

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Section: Introductionmentioning

confidence: 99%

Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds

Álvarez-Muñoz

Indiveri

Rostkowski

et al. 2015

Marine Pollution Bulletin

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“…For example, antibiotic resistant bacteria have been shown to evolve rapidly in areas subject to continual discharge of antibiotics, such as within wastewater treatment plants (WWTP) and even their immediate receiving environments (Rizzo et al, 2013;Everage et al, 2014;Manaia, 2014). Populations of fish exposed to even low concentrations of estrogenic compounds, have shown skewness in sex ratios and much higher incidents of intersex, among other problems (Vajda et al, 2008;Sumpter and Jobling, 2013).…”

Section: Introductionmentioning

confidence: 99%

Pharmaceuticals and Personal Care Products in Municipal Wastewater and the Marine Receiving Environment Near Victoria Canada

2017

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Concerns over the fate of pharmaceuticals and personal care products (PPCP) within the environment have been growing with the advent of more precise analytical methods. The discharge of municipal wastewater has been identified as a significant source of these contaminants, particularly where wastewater treatment is minimal. Here we present results from a comprehensive monitoring regime located around Victoria, BC, Canada. Samples were collected between 2009 and 2016 from a variety of sources including marine water, sediment and biota adjacent to two major untreated sewage outfalls, as well as the sewage itself. PPCP concentrations within the untreated sewage were high, and the sediment surrounding the outfalls showed corresponding contamination. However, this contamination dropped quickly with distance from the outfall such that by 800 m distance most PPCPs were below detection limits. Tissue samples of resident Northern Horse mussels (Modiolus modiolus) collected adjacent to one of the major sewage outfalls showed high single sample concentrations of the antimicrobial triclosan (317 ng g −1 dry weight), the antibiotic ciprofloxacin (176 ng g −1 dry weight), as well as the antidepressant sertraline (84.1 ng g −1 dry weight). Reference stations from around the region showed very low concentrations of contamination with almost all PPCP concentrations being below detection limits. Within the sewage, concentrations were largely stable overtime, with the exception of triclosan and triclocarban which both showed declines over the study period.

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“…It was observed that irrigation of Medicago sativa plants with sewage water, which contained 0.3 µg•L −1 estrogen, resulted in increased vegetative growth [17]. Although significant progress has been made in establishing the biological and ecological consequences of animal exposure to environmental estrogens (EEs) [6] [18], there is still a big gap of knowledge regarding the effects of EEs on plants, especially crop plants as sources of food for an exponentially growing human population.…”

Section: Introductionmentioning

confidence: 99%

Effects of 17<i>β</i>-Estradiol on Growth, Primary Metabolism, Phenylpropanoid-Flavonoid Pathways and Pathogen Resistance in <i>Arabidopsis thaliana</i>

Upadhyay¹,

Maier²

2016

AJPS

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Mammalian sex hormones are spread in the environment from natural and anthropogenic sources. In the present study, the effect of estradiol on Arabidopsis thaliana growth primary metabolism, phenylpropanoid and flavonoid pathways and pathogen resistance were investigated. Treatments of Arabidopsis plants with 10 and 100 nM 17β-estradiol resulted in enhanced root growth and shoot biomass. In addition, treated plants had an increased rate of photosynthesis with a concomitant increase in carbohydrate and protein accumulation. Plants exposed to higher concentrations of 17β-estradiol (10 μM) had significantly lower root growth, biomass, photosynthesis rate, primary metabolite and phenylpropanoid and flavonoid contents indicating a toxic effect of estradiol. Treatments with increasing estradiol concentrations (10 nM, 100 nM and 10 μM) resulted in the downregulation of phenylpropanoid-flavonoid pathway genes (PAL1, PAL4, CHI and ANS) and subsequent decreased accumulation of phenolics, flavonoids and anthocyanins. Estradiol-treated plants were inoculated with Pseudomonas syringae pv. Tomato DC3000 and basal resistance was determined. Estradiol treatments rendered plants susceptible to the pathogen, thus compromising the plant defense mechanisms. These results indicate that at low concentrations, estradiol functions as a biostimulant of growth, yield and primary metabolism of Arabidopsis. However, estradiol functions as a potential transcriptional regulator of the phenylpropanoid pathway genes in Arabidopsis, having a negative effect on the phenylpropanoid and flavonoid biosynthetic pathways.

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The occurrence, causes, and consequences of estrogens in the aquatic environment

Cited by 95 publications

References 27 publications

Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds

Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds

Pharmaceuticals and Personal Care Products in Municipal Wastewater and the Marine Receiving Environment Near Victoria Canada

Effects of 17<i>β</i>-Estradiol on Growth, Primary Metabolism, Phenylpropanoid-Flavonoid Pathways and Pathogen Resistance in <i>Arabidopsis thaliana</i>

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The occurrence, causes, and consequences of estrogens in the aquatic environment

Cited by 95 publications

References 27 publications

Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds

Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds

Pharmaceuticals and Personal Care Products in Municipal Wastewater and the Marine Receiving Environment Near Victoria Canada

Effects of 17&lt;i&gt;β&lt;/i&gt;-Estradiol on Growth, Primary Metabolism, Phenylpropanoid-Flavonoid Pathways and Pathogen Resistance in &lt;i&gt;Arabidopsis thaliana&lt;/i&gt;

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Effects of 17<i>β</i>-Estradiol on Growth, Primary Metabolism, Phenylpropanoid-Flavonoid Pathways and Pathogen Resistance in <i>Arabidopsis thaliana</i>