The Occurrence of Alzheimer’s Disease and Parkinson’s Disease in Individuals With Osteoporosis: A Longitudinal Follow-Up Study Using a National Health Screening Database in Korea

Kwon, Mi Jung; Kim, Joohee; Kim, Jihee; Cho, Seong Jin; Nam, Eun Sook; Choi, Hyo Geun

doi:10.3389/fnagi.2021.786337

Cited by 27 publications

(26 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, vitamin D deficiency along with other endocrine, nutritional and iatrogenic factors may play an important role in bone mass depletion [ 63 ]. In a large longitudinal study including 78,994 patients with osteoporosis and 78,994 controls (from the Korean National Health Insurance Service-Health Screening Cohort database from 2002 to 2015), the first group disclosed a higher incidence of PD (Incidence: 2.4:1000 vs. 1.4:1000 in the control group), suggesting osteoporosis may be a risk factor for PD [ 64 ]. A similar result was reported by another study conducted on 23,495 individuals with osteoporosis compared with 23,495 controls, which revealed in the first group a significant higher risk of PD (HR 1.31, 95% CI, 1.13–1.50, p < 0.001).…”

Section: Role Of Vitamin D In Parkinson’s Diseasementioning

confidence: 99%

Vitamin D Status and Parkinson’s Disease

et al. 2022

View full text Add to dashboard Cite

Parkinson’s disease (PD) is a complex and progressive neurodegenerative disease, characterized by resting tremor, rigidity, slowness of movement, and postural instability. Furthermore, PD is associated with a wide spectrum of non-motor symptoms that add to overall disability. In recent years, some investigations, from basic science to clinical applications, have focused on the role of vitamin D in PD, often with controversial findings. Vitamin D has widespread effects on several biological processes in the central nervous system, including neurotransmission in dopaminergic neural circuits. Various studies have recorded lower levels of vitamin D in PD patients than in healthy controls. Low vitamin D status has also been correlated with the risk for PD and motor severity, whereas less is known about the effects vitamin D has on cognitive function and other non-motor symptoms. This review aims to better characterize the correlation between vitamin D and PD, clarify the role of vitamin D in PD prevention and treatment, and discuss avenues for future research in this field.

show abstract

Section: Role Of Vitamin D In Parkinson’s Diseasementioning

confidence: 99%

Vitamin D Status and Parkinson’s Disease

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Although we found no causal link between osteoporosis and AD, previous observational studies have shown a strong association between osteoporosis and AD. A cohort study found a 1.49-fold higher prevalence of AD in the osteoporosis group than in the control group after correcting for age and sex, and its results suggested that the presence of osteoporosis increases the potential for AD in adults over 40 years old ( Kwon et al, 2021 ). Another cohort study also found that osteoporosis was positively associated with cognitive and functional decline and that subjects with BMD values in the lowest quartile had a 2-fold increased risk of AD transition compared to controls ( Zhou et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

No genetic causal association between Alzheimer’s disease and osteoporosis: A bidirectional two-sample Mendelian randomization study

Mei

Cai

et al. 2023

Front. Aging Neurosci.

View full text Add to dashboard Cite

ObjectiveMany observational studies have found an association between Alzheimer’s disease (AD) and osteoporosis. However, it is unclear whether there is causal genetic between osteoporosis and AD.MethodsA two-sample Mendelian randomization (MR) study was used to investigate whether there is a causal relationship between osteoporosis and AD. Genes for osteoporosis and AD were obtained from published the genome-wide association studies (GWAS). Single nucleotide polymorphisms (SNPs) with significant genome-wide differences (p < 5 × 10−8) and independent (r2 < 0.001) were selected, and SNPs with F ≥ 10 were further analyzed. Inverse variance weighted (IVW) was used to assess causality, and the results were reported as odds ratios (ORs). Subsequently, heterogeneity was tested using Cochran’s Q test, pleiotropy was tested using the MR–Egger intercept, and leave-one-out sensitivity analysis was performed to assess the robustness of the results.ResultsUsing the IVW method, MR Egger method, and median-weighted method, we found that the results showed no significant causal effect of osteoporosis at different sites and at different ages on AD, regardless of the removal of potentially pleiotropic SNPs. The results were similar for the opposite direction of causality. These results were confirmed to be reliable and stable by sensitivity analysis.ConclusionThis study found that there is no bidirectional causal relationship between osteoporosis and AD. However, they share similar pathogenesis and pathways.

show abstract

“…Osteoporosis was designated as ICD-10 codes M80 (osteoporosis with pathological fracture), M81 (osteoporosis without pathological fracture), and M82 (osteoporosis in diseases classified elsewhere) [ 25 , 26 ]. Amongst them, we chose only people who underwent more than two times treatments in basis upon the bone density test of X-ray or computed tomography (Claim code: HC341-HC345, E7001-E7004) [ 25 , 26 ].…”

Section: Methodsmentioning

confidence: 99%

Potential Association of Osteoporosis and Not Osteoporotic Fractures in Patients with Gout: A Longitudinal Follow-Up Study

et al. 2022

Self Cite

View full text Add to dashboard Cite

Health issues associated with gout and increased occurrence of osteoporosis or fractures have been raised; however, the results are elusive. Herein, we explored the possible link between gout and incident osteoporosis/osteoporotic fractures based on long-term follow-up nationwide data. This study enrolled 16,305 patients with gout and 65,220 controls who were matched by propensity score at a 1:4 ratio on the basis of sex, age, income, and residence from the Korean National Health Insurance Service-Health Screening Cohort database (2002–2015). A Cox proportional hazard model was employed to identify the relevance between gout and incident osteoporosis/fractures, following adjustment for various covariates. In the follow-up period, osteoporosis developed in 761 individuals with gout and 2805 controls (incidence rates: 8.0 and 7.3/1000 person-years, respectively), and each osteoporotic fracture in the distal radius (2.8 vs. 2.7/1000 person-years), hip (1.3 vs. 1.3/1000 person-years), and spine (4.5 vs. 4.5/1000 person-years) occurred in gout and control groups, respectively. After adjustment, the gout group presented an 11% higher development of osteoporosis (95% confidence interval = 1.02–1.20) than the controls (p = 0.011). Subgroup analyses maintained the augment of incident osteoporosis in sufferers with gout, particularly in either men or <60 years. However, no such relevance was identified between gout and incident osteoporotic fractures at any site. In conclusion, gout may result in a slightly elevated likelihood of developing osteoporosis, and not osteoporotic fractures, in the Korean population.

show abstract

The Occurrence of Alzheimer’s Disease and Parkinson’s Disease in Individuals With Osteoporosis: A Longitudinal Follow-Up Study Using a National Health Screening Database in Korea

Cited by 27 publications

References 45 publications

Vitamin D Status and Parkinson’s Disease

Vitamin D Status and Parkinson’s Disease

No genetic causal association between Alzheimer’s disease and osteoporosis: A bidirectional two-sample Mendelian randomization study

Potential Association of Osteoporosis and Not Osteoporotic Fractures in Patients with Gout: A Longitudinal Follow-Up Study

Contact Info

Product

Resources

About