The occurrence of anti-titin antibodies and thymomas

Somnier, Finn E.; Engel, Peter J.

doi:10.1212/wnl.59.1.92

Cited by 49 publications

(47 citation statements)

References 31 publications

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“…Our estimation, in agreement with other fi ndings [10] , fails to confi rm the balanced ratio of 1 in patients with MG and thymoma as previously suggested [12] . Thymoma was not present in equal proportion in the two sexes across the different age groups.…”

Section: Discussionsupporting

confidence: 81%

“…The total patient population was signifi cantly weighed in favor of the female patients. According to other studies [3,4,8,10] , the incidence rates disclosed a different age-related incidence pattern in the two genders with an early increase in the third decade in the female sex, and a later increase with age without definite gender preponderance. The results agree with the observation that MG increases with increasing age, emphasizing the importance of MG in the elderly.…”

Section: Discussionmentioning

confidence: 81%

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Incidence of Myasthenia gravis in the Province of Ferrara

et al. 2004

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Background: The reported annual incidence of myasthenia gravis (MG) ranges from 0.25 to 15 per million. The sex- and age-related pattern of disease incidence is still debated. Methods: An intensive descriptive study was performed in the province of Ferrara (mean population 360,950 people) over the period 1985 through 2000. Results: The average crude annual incidence rate was 2 per 100,000. We confirm a female preponderance in the total population, particularly in the youngest age groups. Conclusions: We observed an early increase in incidence in females, partly due to thymoma-associated MG, while MG without thymoma showed increasing incidence with age nonsignificantly different in the two sexes.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 81%

Incidence of Myasthenia gravis in the Province of Ferrara

et al. 2004

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“…Most of the studies included in this review reported on incidence rates for populations in Europe: the rates from 1970 to 2000 varied between 4.1 [13] and 30/1,000,000/ year [14] . Six studies reported on regions outside Europe: Tanzania, Hong Kong, Japan, North America, Cuba and Curaçao and Aruba and the incidence rates found in these areas ranged from 3.0 to 9.1/1,000,000/year.…”

Section: Incidence Rates Geographical Variationmentioning

confidence: 99%

“…In studies of incidence rates in males, the rates increased up to the 60-to 80-year age band in most studies [13,[15][16][17][18][19][20][21][22][23][24][25] , with 2 showing an increase to the 40-year age band [26,27] and 2 reporting fluctuations in rate with age but an overall increase [28,29] . In females, there was more fluctuation in incidence rates with age with some studies showing a peak in incidence at 20-40 years and then a second one at 50-70 years [15, 17, 19-23, 26, 27, 29] , others just had a peak in incidence in the latter age band [13,18,24] . In some studies [13,20,22,25,29,30] the incidence in the elderly (65 or 70 years upwards) was reported to be 0/1,000,000/year, which indicates possible underdiagnosing or misdiagnosing of patients in this group [20,30] .…”

Section: Incidence Rates Geographical Variationmentioning

confidence: 99%

The Incidence of Myasthenia Gravis: A Systematic Literature Review

2010

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Background: A systematic review of literature published between 1980 and 2007, on the incidence of myasthenia gravis, was undertaken. Methods: All relevant papers found through searches of Medline, Embase and Science Direct were critically appraised and an assessment was made of the reliability of the reported incidence data. Results: Thirty-one studies were included in the review, the majority of which investigated populations in Europe. The incidence rates reported were between 3.0 and 30.0/1,000,000/year. However, it is thought that the rates at the upper end of this range, reported by the prospective studies, provided the most accurate estimates. Overall, incidence rates have increased over time owing to a greater awareness of the disease and improved methods of diagnosis. Conclusions: The most accurate estimate of incidence of myasthenia gravis was around 30/ 1,000,000/year. The incidence in children and adolescents aged 0–19 years was found to be between 1.0 and 5.0/ 1,000,000/year. The rates presented in this review are likely to be an underestimate of the true incidence rates, as mild cases will have been missed and cases in the elderly will have been misdiagnosed.

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“…Ryanodine receptor antibodies are often associated with malignant thymoma [33]. Apart from MG with thymoma, anti-titin antibodies have been observed to be an exclusive feature of late-onset MG [34].…”

Section: Introductionmentioning

confidence: 99%

Presynaptic Membrane Receptor in Human Brain

et al. 2012

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Myasthenia gravis (MG) is an autoimmune disease that results from antibody mediated damage of Acetylcholine receptor (AChR) at the neuromuscular junction. The autoimmune character of MG and pathogenic role of AChR antibodies have been established by several workers i.e., the demonstration of anti-AChR antibodies in about 90 % of MG patients. It has been demonstrated that patients with MG also have antibodies against a second protein named presynaptic membrane receptor (PsmR), which is identified by utilizing b-Bgtx, a ligand which binds to PsmR. Using b-Bgtx Sepharose 4B affinity matrix, the PsmR was purified from different regions of human cadaver brain by affinity chromatography. Purified receptor was characterized both by biochemical and immunological procedures. PsmR purified from different regions of the brain shows a specific activity of 0.37 ± 0.01, 0.39 ± 0.02 and 0.43 ± 0.005 nM/ lg of protein in Parietal lobe,

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The occurrence of anti-titin antibodies and thymomas

Cited by 49 publications

References 31 publications

Incidence of Myasthenia gravis in the Province of Ferrara

Incidence of Myasthenia gravis in the Province of Ferrara

The Incidence of Myasthenia Gravis: A Systematic Literature Review

Presynaptic Membrane Receptor in Human Brain

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