The occurrence of Chlamydia trachomatis in the semen of men participating in an IVF programme

Nagy, Bálint; Corradi, G; Vajda, Zoltán; Gimes, R; Csömör, S

doi:10.1093/oxfordjournals.humrep.a136845

Cited by 31 publications

(17 citation statements)

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“…They failed to find any evidence of Chlamydia trachomatis in prostatic tissue after culture and immunofluoresence or after serological investigations. When urethral smears were cultured from 175 infertile men with a poor post-coital test, the number of positives increased to 15% (Soffer et a/., 1990), which is similar to the 14% registered by Nagy et al (1989) in 184 asymptomatic men participating in an IVF programme. Moreover, Berger et al (1989) failed to demonstrate the presence of Chlamydia trachomatis in the prostatic fluid of 34 men with chronic prostatitis using cultures.…”

Section: Non-bacterial Prostatitismentioning

confidence: 63%

Infection in the male reproductive tract. Impact, diagnosis and treatment in relation to male infertility

Purvis¹,

Christiansen²

1993

Int J of Andrology

177

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The following are the conclusions that can be derived from a review of the literature regarding the role of infection in the aetiology of male infertility. (i) Temporary inflammatory episodes in the male reproductive tract which are self-limiting are probably common. (ii) Caution should be exercised in the use of leukospermia or bacteriospermia as parameters for glandular infection. (iii) There is a need for alternative techniques for detecting non-symptomatic deep pelvic infections in the male; one technique of great promise is rectal ultrasound. (iv) Rectal ultrasound indicates that a large number of men with poor sperm quality have a non-symptomatic, chronic prostatovesiculitis. (v) Increasing evidence implicates Chlamydia trachomatis as being a major cause of chronic non-bacterial prostatitis. (vi) An important aspect of chlamydial infections in men may be that the male accessory sex glands may function as reservoirs for the organism, increasing the probability of infection in the female. (vii) Ureaplasma urealyticum may also play an important aetiological role in male infertility but its significance is confounded by its acknowledged function as a commensal in the reproductive tract. (viii) One of the manifestations of male reproductive tract infection is the induction of sperm autoantibodies. (ix) There is a need for more systematic controlled studies of the effects of antibiotic treatment on sperm quality with different preparations for extended periods using patient groups in which a glandular infection has been verified, e.g. by rectal ultrasonography.

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Section: Non-bacterial Prostatitismentioning

confidence: 63%

Infection in the male reproductive tract. Impact, diagnosis and treatment in relation to male infertility

Purvis¹,

Christiansen²

1993

Int J of Andrology

177

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“…The incidence of C. trachomatis infection in asymp tomatic males has been reported to range from 2 to 16%, depending on the detection method employed [8,22,24], Nagy et al [24] have reported that the frequency of C. tra chomatis isolation from the semen of 184 asymptomatic men participating in an IVF (in vitro fertilization) pro gram was 14.1% when McCoy fibroblast cells were used for culture. Wolff et al [22] reported that the incidence of C. trachomatis isolation from semen samples of 209 infer tile patients was 2.4% when EIA (Chlamydiazyme) was used to study samples of the cellular fraction of semen [22], van den Brule et al [8] reported that the prevalence of asymptomatic C. trachomatis infection was 16% in the semen of artificial insemination donors when the poly merase chain reaction was used for detection.…”

Section: Discussionmentioning

confidence: 99%

<i>Chlamydia trachomatis</i> Infection in the Semen of Asymptomatic Infertile Men: Detection of the Antigen by in situ Hybridization

Yoshida

Kobayashi²,

Negishi³

1994

Urol Int

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The prevalence of Chlamydia trachomatis and other microbes was studied in 94 semen samples from asymptomatic infertile males. Simultaneously, we sought evidence for inflammation of the genital tract by determining the polymorphonuclear granulocyte (PMN)-elastase concentration in the seminal plasma. The C. trachomatis genome was detected in 8 cases using in situ hybridization. The antigen, however, was undetectable by enzyme-linked assay (Chlamydiazyme) in the same samples. Ureaplasma urealyticum was isolated from 16 cases. The PMN-elastase concentration in the semen positive for the C. trachomatis genome was significantly higher than in C trachomatis-negative and U. urealyticum-positive cases, but no significant difference was observed between C. trachomatis-mgative and U. urealyticum-positive cases. C. trachomatis in situ hybridization-positive cases correlated well with C trachomatis-specific IgA antibody positivity and a PMN-elastase concentration over 250 ng/ml. These findings suggest that in situ hybridization is a reliable method for the detection of C. trachomatis infection and that the presence of C. trachomatis, but not U. urealyticum, in the male genital tract correlated well with evidence of inflammation.

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“…Semen abnormalities are associated with chlamydia1 infections [4] and C. truchomatis is attached to spermatozoa recovered from the peritoneal cavity of patients with salpingitis [5]. However, no significant difference was observed between Chlumydiuinfected and noninfected patients when semen parameters (cell count, motility, bovine mucus penetration, and hypoosmotic swelling test) were compared [9]. To date, microbiological behavior of C. truchomtis has been studied in culture of infected MacCoy cells (mouse L cells) and several other tissue culture cell lines.…”

Section: Discussionmentioning

confidence: 99%

Electron Microscopy ofChlamydia trachomatisInfection of the Male Genital Tract

Villegas

Piñón

Shor

et al. 1991

Archives of Andrology

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Semen specimens and testicular and epididymis biopsy from a patient of an infertile marriage were examined by transmission electron microscopy. Intraepithelial vesicles containing C. trachomais were present in remaining cytoplasmic droplets in spermatozoa, desquamated epithelial cells, and stereocilia from epididymis. Elementary bodies were demonstrated in connective tissue from testes and in Leydig cells. The association between the microorganisms and spermatozoa contribute to the decreased motility and necrospermia. The morphologic alterations in epididymis are responsible for decreased sperm maturation. The damage to Leydig cells can be demonstrated only by electron microscopy.

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The occurrence of Chlamydia trachomatis in the semen of men participating in an IVF programme

Cited by 31 publications

References 0 publications

Infection in the male reproductive tract. Impact, diagnosis and treatment in relation to male infertility

Infection in the male reproductive tract. Impact, diagnosis and treatment in relation to male infertility

<i>Chlamydia trachomatis</i> Infection in the Semen of Asymptomatic Infertile Men: Detection of the Antigen by in situ Hybridization

Electron Microscopy ofChlamydia trachomatisInfection of the Male Genital Tract

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