1996
DOI: 10.1007/bf02505276
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The occurrence of cutaneous nerve endings and neuropeptides in vitiligo vulgaris: a case-control study

Abstract: Pioneering studies both in humans and animals have demonstrated an association between the peripheral nervous system and epidermal melanocyte destruction. The presence of certain neuropeptides and neuronal structural markers in peripheral nerve fibres was investigated in involved and uninvolved vitiligo skin and compared with normal healthy skin. A group of 18 vitiligo vulgaris patients and matched healthy volunteers participated in the investigation. The indirect immunofluorescence technique was employed. The… Show more

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Cited by 52 publications
(30 citation statements)
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“…This view has been recently challenged in a case-control study; however, a reduced ability to cope with stress may contribute to the clinical findings (38). There is a marked increase of calcitonin gene related peptide (CGRP) positive nerve fibers in involved skin (39). Catechol-O-methyltransferase (COMT) activity is higher in epidermal homogenates from NSV as compared with controls (40).…”
Section: Melanocyte Destructionmentioning
confidence: 99%
“…This view has been recently challenged in a case-control study; however, a reduced ability to cope with stress may contribute to the clinical findings (38). There is a marked increase of calcitonin gene related peptide (CGRP) positive nerve fibers in involved skin (39). Catechol-O-methyltransferase (COMT) activity is higher in epidermal homogenates from NSV as compared with controls (40).…”
Section: Melanocyte Destructionmentioning
confidence: 99%
“…Th e emergence of segmental vitiligo can be best explained by the neurogenic theory according to which the nerve endings release the neurochemical mediators that inhibit melanogenesis or have toxic eff ects on melanocytes, destroying them. Microscopic examination and ultrastructural investigations in people with segmental vitiligo showed damage to axons and disrupted neuropeptide balance in vitiligo lesions (27,28). As possible provoking factors for the occurrence of vitiligo the following are cited: stress, sun burns, recurrent skin injuries.…”
Section: Th E Etiology and Pathogenesis Of Vitiligomentioning
confidence: 99%
“…Son y›llarda yap›lan çal›flma-lar bu görüflleri desteklemifl ve genel olarak stresli yaflam olaylar› ile deri hastal›klar›n›n ortaya ç›k›fl› aras›nda bir iliflki oldu¤u üzerinde görüfl birli¤ine var›lm›flt›r 8,9,10 . S.Freud'un gelifltirdi¤i psikanalitik söylemden yola ç›kan baz› araflt›rmac›lar, deri hastal›klar›n› psikolojik baz› çat›flmalar›n konversiyon mekanizmalar› arac›l›¤› ile bedensel belirtilere neden olmas›yla aç›klam›fl ya da özgün nörofizyolojik bozukluklara ba¤lam›fllard›r 11 .…”
Section: Psikolojik Etkenlerin Deri Hastal›klar›na Etkisiunclassified