The occurrence of four inheritable morphological variations in mice and their possible relation to treatment with x‐rays

Little, C. C.; Bagg, Halsey J.

doi:10.1002/jez.1400410106

Cited by 66 publications

(11 citation statements)

References 9 publications

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“…A second type of Asian M. musculus Y Chr is shared by 20 of the inbred strains examined, including C57BL/6, C57BL/10, C57BR, C57L, and C58. The progenitor stocks to C57BL, C57BR, C57L, and C58 are known to be related through paternal ancestry, because a single male (mouse #52) was mated to two different females (#57 and #58) to produce the C57 and C58 lineages, respectively (Little and Bagg 1924). The observation that a large number of inbred strains carry the C57BL-type Y Chr may reflect the fact that these strains are related through paternal ancestry, because the progenitors of many inbred strains, including C57BL, can be traced back to A.E.C.…”

Section: Discussionmentioning

confidence: 99%

Geographic origin of the Y Chromosomes in ?old? inbred strains of mice

et al. 1992

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Six distinct Y Chromosomes (Chr) were identified among 39 standard inbred strains of mice with five probes that identified Y Chr-specific restriction fragments on Southern blots. Three Y Chr types, distributed among 31 strains, were of Asian Mus musculus origin. The remaining three Y Chr types, distributed among eight strains, were of M. domesticus origin. The Asian source of the M. musculus Y Chr was confirmed by determining the DNA sequence of 221 bp from an open reading frame within the Sry (sex determining region Y) gene (Gubbay et al., Nature 346: 245-250, 1990) in three inbred strains (C57BL/6J, AKR/J, and SWR/J) and comparing the sequence to the homologous sequences derived from wild caught European and Asian M. musculus males. These data indicate that a minimum of six male mice contributed to the formation of the old inbred strains.

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Section: Discussionmentioning

confidence: 99%

Geographic origin of the Y Chromosomes in ?old? inbred strains of mice

et al. 1992

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“…The observed lesions resemble the abnor malities described in the offspring of X-ray treated mice [2,7], Comparable lesions have also been described in the br/br rabbits by Greene and Saxton [4], In this rabbit stock, it was reported that the primary defect is a blood abnormality, and that it is possible to prevent the amputations by several types of appropriate treatments administered to the pregnant females [16][17][18],…”

Section: Discussionmentioning

confidence: 83%

Phenytoin Administration to Pregnant Mice: a Mutagenic Action?

1981

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Phenytoin orally administered to pregnant NMRI mice results in limb haemorrhages, necrosis, and in most cases in limb amputations in the offspring. By mating these offspring without any treatment, the same type of abnormalities appeared throughout seven successive generations. In the second and third generations, other malformations, such as haemorrhages of the eyelids, and genitourinary defects were observed. These findings raise the question of the mutagenic role of phenytoin. Phenytoin is a drug of considerable medical use, but very little is known about the various possible intermediate steps involved in its action.

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“…Thus, in 1994, Darling and Gossler [20] wrote a review entitled A mouse model for Fraser syndrome. They stated that the first mouse bleb mutants were described by Little and Bagg in 1924 [21], but, as mentioned above, Asayama in Japan in 1906 [6] had already described eight cases of cryptophthalmos among 50 inbred mice.…”

Section: Yours Sincerelymentioning

confidence: 99%

Fraser Syndrome: Two millennia of cryptophthalmos from Pliny the Elder to FRAS, FREM and GRIP: A historical perspective

Fraser¹

2013

OJGen

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From its first description in antiquity, the place of cryptophthalmos in the history of medical genetics is briefly set out until, in the twentieth century, this rare constellation of multiple congenital malformations of which cryptophthalmos is the most striking, even though not obligatory, component, was identified as an inherited autosomal recessive condition. It was given the name of Fraser syndrome and mutant alleles of the genes FRAS1, FREM2 and GRIP1 were identified as being responsible for a proportion of cases. In the remainder of cases, it may be supposed that mutant alleles of other genes, as yet unidentified, are responsible. In general, this association of multiple disparate malformations in an autosomal recessive condition may be expected to throw light on important aspects of gene action in embryogenesis. An aspect of medical genetics, which has become important with respect to the condition, is antenatal diagnosis with the prospect of abortion of affected fetuses.

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The occurrence of four inheritable morphological variations in mice and their possible relation to treatment with x‐rays

Cited by 66 publications

References 9 publications

Geographic origin of the Y Chromosomes in ?old? inbred strains of mice

Geographic origin of the Y Chromosomes in ?old? inbred strains of mice

Phenytoin Administration to Pregnant Mice: a Mutagenic Action?

Fraser Syndrome: Two millennia of cryptophthalmos from Pliny the Elder to FRAS, FREM and GRIP: A historical perspective

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