The occurrence of multiple steroid hormone receptors in disease-free and neoplastic human ovary

Galli, M. C.; Giovanni, Carla De; Nicoletti, Giordano; Grilli, Sandro; Nanni, Patrizia; Prodi, Giorgio; Gola, G.; Rocchetta, R.; Orlandi, C

doi:10.1002/1097-0142(19810315)47:6<1297::aid-cncr2820470611>3.0.co;2-d

Cited by 71 publications

(16 citation statements)

References 16 publications

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“…Receptors for estrogens (ER), progesterone (PR), and androgens (AR) are present in normal ovaries, as well as in benign ovarian tumors (63, [86][87][88][89][90][91][92][93][94][95]. Steroid hormone receptors have also been detected in malignant epithelial ovarian tumors (Table 2).…”

Section: Hormone Receptorssupporting

confidence: 92%

Endocrine Factors in Common Epithelial Ovarian Cancer*

1991

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Section: Hormone Receptorssupporting

confidence: 92%

Endocrine Factors in Common Epithelial Ovarian Cancer*

1991

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“…Moreover, several lines of evidence suggest the importance of estrogens as the relevant hormone. For instance, estrogen receptors have been found in cytosols of normal and benign ovaries (5)(6)(7)(8)(9) and other studies have confirmed the expression of both estrogen receptor a and h in human ovarian corpus luteum tissue (10) and cultured ovarian surface epithelial cells (11). As well, increased estrogenic influences during the menstrual cycle have been shown to increase the proliferation of the epithelium, whereas reports on hormone replacement therapy (HRT) with conjugated estrogens have also indicated increased risk of ovarian cancer.…”

Section: Introductionmentioning

confidence: 80%

Estrogen Bioactivation, Genetic Polymorphisms, and Ovarian Cancer

Sellers

Schildkraut

Pankratz³

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Recent experimental evidence has shown that catechol estrogens can be activated through metabolism to form depurinating DNA adducts and thereby initiate cancer. Limited data are available regarding this pathway in epithelial ovarian cancer. We conducted a case-control study of 503 incident epithelial ovarian cancer cases at the Mayo Clinic in Rochester, MN, and Jacksonville, FL, and a 48-county region in North Carolina. Six hundred nine cancerfree controls were frequency matched to the cases on age, race, and residence. After an interview to obtain data on risk factors, a sample of blood was collected for DNA isolation. Subjects were genotyped for seven common single nucleotide polymorphisms in four genes involved in catechol estrogen formation (CYP1A1 and CYP1B1) or conjugation (COMT and SULT1A1). Data were analyzed using logistic regression, stratified by race, and with adjustment for design factors and potential confounders. None of the individual genotypes were significantly associated with ovarian cancer risk. However, an oligogenic model that considered the joint effects of the four candidate genes provided evidence for an association between combinations of these genes and ovarian cancer status (P = 0.015). Although preliminary, this study provides some support for the hypothesis that lowpenetrance susceptibility alleles may influence risk of epithelial ovarian cancer. (Cancer Epidemiol Biomarkers Prev 2005;14(11):2536 -43)

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“…An effect of diet through a hormonal mechanism is consistent with findings of oestrogen receptors in epithelial ovarian tumours (Friberg et al, 1978;Holt et al, 1979;Galli et al, 1981). It has been suggested that a diet high in animal fats can produce extragenital oestrogen via gut bacteria (Hill et al, 1971) and that oestrogen bioavailability is altered in vegetarian women (Armstrong et al, 1981;Goldin et al, 1981).…”

Section: Resultsmentioning

confidence: 99%

Dietary factors and epithelial ovarian cancer

Shu

Gao²,

Yuan³

et al. 1989

Br J Cancer

129

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Summary Dietary data from a population-based case-control study of 172 epithelial ovarian cancer cases and 172 controls were analysed. A significant (P<0.01) dose-response relationship was found between intake of fat from animal sources and risk of ovarian cancer, but plant fat was not associated. Although the effect of animal fat was confounded by education, an adjusted odds ratio of 1.8 persisted for those in the upper quartile compared to the lower quartile of consumption (P for trend=0.03). After adjustment for animal fat intake, calorific and protein intake had minimal effects on risk. Total vegetables were found to be somewhat protective, but the mechanism of action was unclear. Weight, height and relative weight (weight/height2) were not related to risk of ovarian cancer.Substantial evidence indicates that diet is a major factor in the cause of some of the most important and prevalent human cancers, especially cancers of the digestive tract and hormone-dependent cancers (Williams & Weisburger, 1986). An involvement of dietary fat in the aetiology of ovarian cancer has been suggested by some epidemiological studies (Armstrong & Doll, 1975;Cramer et al., 1984;Rose et al., 1986;La Vecchia et al., 1987). Experimental studies have shown that dietary fat is related to endogenous hormone levels, providing a plausible mechanism for the association (Willett & MacMahon, 1984b Information on usual adult consumption of 63 common foods in Shanghai was obtained. Study subjects were first asked about how often they ate each food (daily, weekly, monthly, yearly, seldom or never), followed by questions to derive the grams of food eaten per unit time. The women, who generally were responsible for buying and preparing the meals for their households, adjusted the quantities purchased by the fraction they consumed. The food composition table published by the Chinese Academy of Medical Sciences (1981) was employed to convert these foods into nutrients. The majority of nutrient values were based on data derived from the Shanghai area; when this information was missing, values from Jiangsu province, and occasionally from Beijing, were utilised. Data were not available on saturated and unsaturated fat in Chinese foods so it was not possible to examine these two variables. Multiplying the reported daily consumption (in grams) of each individual food by the nutrient content per gram in that food, and then summing over all foods, generated for each individual the total daily ingestion of each nutrient. In addition, food groups were formed based on dietary or botanical similarities. For example, meats included pork, pork chops, spareribs, pigs' feet, salted pork, pork liver, organ meats, beef, lamb, chicken and duck; the cruciferous vegetables included greens, cabbage, Chinese cabbage and cauliflower; and alium consisted of foods in the onion family (see Table VI for further details).The odds ratio (OR, estimated relative risk) was employed in measuring the association between diet and ovarian cancer. Based upon the distribution amon...

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The occurrence of multiple steroid hormone receptors in disease-free and neoplastic human ovary

Cited by 71 publications

References 16 publications

Endocrine Factors in Common Epithelial Ovarian Cancer*

Endocrine Factors in Common Epithelial Ovarian Cancer*

Estrogen Bioactivation, Genetic Polymorphisms, and Ovarian Cancer

Dietary factors and epithelial ovarian cancer

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