The Occurrence of Poliomyelitis Following Tonsillectomy

Aycock, W. Lloyd; Luther, Eliot H.

doi:10.1056/nejm192901242000402

Cited by 58 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here it will be noted that in 34.8 per cent of the patients who died there was a history of stress or previous illness, whereas all patients, whether they had paralysis or not, gave a history of stress or illness prior to onset in 20. 3 in only 5.4 per cent, and for the remaining three control groups it varied between 5.4 and 9.0. Too' much emphasis should not be placed upon data of this type, for there are evident weaknesses in history of illness obtained by questioning.…”

Section: Poliomyelitis In the " Special District "mentioning

confidence: 81%

Epidemiology of Poliomyelitis in Detroit in 1939

Top¹,

Vaughan²

1941

Am J Public Health Nations Health

View full text Add to dashboard Cite

Section: Poliomyelitis In the " Special District "mentioning

confidence: 81%

Epidemiology of Poliomyelitis in Detroit in 1939

Top¹,

Vaughan²

1941

Am J Public Health Nations Health

View full text Add to dashboard Cite

“…Our own findings suggest that as regards the central nervous system an immunity of this type might not be very substantial since its influence probably would be restricted to the region of immediate exposure. Recent studies of human pathological material point increasingly to the utilization of several portals of entry in man (35)(36)(37)(38)(39)(40), so that in order to produce effective immunity an antecedent attack must conceivably close a variety of portals leading to the neuraxis along various peripheral nerves. At the moment one can do no more than speculate on the means by which this might be accomplished.…”

Section: Discussionmentioning

confidence: 99%

Second Attacks of Poliomyelitis

Howe

Bodian

1941

Journal of Experimental Medicine

View full text Add to dashboard Cite

1. It was found in forty rhesus monkeys that intracerebral, intraocular, intracutaneous, intraperitoneal, intraspinal, and neural inoculations of poliomyelitis virus produced no lesions in the olfactory bulbs despite the fact that the animals contracted pronounced paralyses. This indicated that the virus could be restricted to certain neuronal systems. 2. Similarly intranasal inoculation of seven animals produced no lesions in the ciliary ganglia. 3. Two monkeys convalescent from an intracutaneous and an intracerebral inoculation respectively had further paralyses after intranasal inoculation of heterologous virus. A third animal convalescent from an intranasal inoculation showed extension of lesions after intranasal and intraocular inoculation with heterologous virus. 4. Two spinal animals in which an attack of poliomyelitis was limited to an isolated segment of spinal cord, contracted typical paralyses in the previously uninvaded portions of the CNS following intranasal inoculation of homologous virus. 5. Four of six convalescent monkeys showed extension of lesions but no clinical signs after homologous virus inoculation through a previously un-invaded portal. 6. Four animals convalescent from a unilateral intranasal inoculation showed evidence of new invasion in the opposite olfactory bulb but no extension of paralyses following a second inoculation of homologous virus into the appropriate nostril. 7. Two animals had second attacks after heterologous second inoculations. The intranasal portal was employed for both exposures. 8. It thus seems apparent that in the rhesus monkey a second attack of poliomyelitis, whether paralytic or not, seems to depend upon the strains of virus used and the degree to which virus is disseminated through the neuraxis during the first exposure. 9. The above experimental data emphasize the difficulty of utilizing the rhesus monkey for experiments seeking to elucidate the mechanisms of immunity in man and suggest that human immunity to poliomyelitis does not result from immunization of the nervous system but rather is the result of some process which prevents infective quantities of active virus from reaching nervous tissue.

show abstract

“…Incubation periods in 29 paralytic cases of poliomyelitis, estimated by Casey.8 B. Intervals between tonsillectomy and onset of bulbar poliomyelitis in 54 cases (combined data of several studies. [4][5][6][7][8] C. Intervals between tonsillectomy and onset of spinal poliomyelitis in 28 cases (from the same studies as (B)).…”

mentioning

confidence: 99%

The Incubation Period of Poliomyelitis

Sartwell¹

1952

Am J Public Health Nations Health

View full text Add to dashboard Cite

The Occurrence of Poliomyelitis Following Tonsillectomy

Cited by 58 publications

References 0 publications

Epidemiology of Poliomyelitis in Detroit in 1939

Epidemiology of Poliomyelitis in Detroit in 1939

Second Attacks of Poliomyelitis

The Incubation Period of Poliomyelitis

Contact Info

Product

Resources

About