The occurrence of proteinuria in dogs treated with masitinib

Abstract

RESULTSMedian age at presentation was 7 years, with 8 males and 7 females. No breed predisposition was highlighted. 9/15 were multi-centric and 4/15 intestinal/mesenteric lymphoma. WHO stage III, IV and IV were reported in 8/15, 5/15 and 2/15 dogs respectively. 6 dogs were sub-stage a and 9 sub-stage b. B-cell and T-cell lymphomas were identified in 2/5 and 3/5 dogs respectively. GPS of 0, 1 and 2 were documented in 3/15, 8/15 and 4/15 dogs. MST for dogs with a mGPS of 0 was 277 days (range 210-1672), mGPS of 1, 164 days (range 76-1491) and mGPS of 2, 7 days (1-64 days). Kaplan-Meier analysis revealed dogs with mGPS of 2 had significantly shorter MSTs than dogs with mGPS 0 or 1. Dogs with an mGPS of 0 had significantly longer MST than dogs with GPS of 1 or 2.