The Occurrence of Psammoma Bodies in Papillary Adenocarcinoma of the Lung

Unterman, David H.; Reingold, Irving M.

doi:10.1093/ajcp/57.3.297

Cited by 22 publications

(14 citation statements)

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“…Psammoma bodies are concentrically lamellated microscopic structures made of calcium that are 25–150 μm in size . They were previously proposed to be degenerated neoplastic cells, proteins secreted from neoplastic cells, or a mixture of these; however, the origin of and mechanisms underlying the generation of psammoma bodies currently remain unknown.…”

Section: Introductionmentioning

confidence: 99%

“…They were previously proposed to be degenerated neoplastic cells, proteins secreted from neoplastic cells, or a mixture of these; however, the origin of and mechanisms underlying the generation of psammoma bodies currently remain unknown. Psammoma bodies are more commonly observed in papillary carcinomas of the thyroid gland, serous papillary adenocarcinomas of the ovary, and meningioma, but are occasionally detected in other neoplasms, including lung cancers . Only one study, published in 1972, has systematically described the significance of psammoma bodies in lung adenocarcinomas .…”

Section: Introductionmentioning

confidence: 99%

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Update on the potential significance of psammoma bodies in lung adenocarcinoma from a modern perspective

Miyake

Okihara²,

Matsumura

et al. 2017

Histopathology

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Update on the potential significance of psammoma bodies in lung adenocarcinoma from a modern perspective

Miyake

Okihara²,

Matsumura

et al. 2017

Histopathology

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“…Thus, the presence of PB in sputum smears could have important diagnostic value, because if we take into account that the cases we found during our research are not too many (9/9), the positive predictive value for PB in sputum smears and the presence of lung adenocarcinoma was 100%. Unterman and Reingold have described a 16% prevalence of psammomatous calcification within papillary adenocarcinoma of the lung in autopsies.…”

Section: Discussionmentioning

confidence: 99%

Calcareous concretions and psammoma bodies in sputum smears: Do these similar structures have different clinical significance?

Martínez‐Girón

Martínez-Torre

Tamargo-Peláez

et al. 2014

Diagnostic Cytopathology

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Different noncellular elements, such as round concentric calcified laminated structures, may be found in sputum smears. If these structures appear isolated on the background of the smear, the term usually used to describe them is "calcareous concretions" (CC). On the contrary, when the structures are part of epithelial cell groups or small tissue fragments, the term used to describe them is "Psammoma bodies" (PB). The aim of this work is to establish the relationship between these structures and pulmonary disease, especially lung carcinoma, by searching for the presence of CC and/or PB in sputum smears. Our study has taken as a basis 16.716 sputum smears from 696 patients obtained during a 7-year period (2003-2009). After reviewing them, it was found that from the total, 66 cases (0.39%) contained round calcified structures, 57 of them (0.34%) corresponding to CC, and the remaining 9 ones (0.05%) corresponding to PB. From these 57 CC cases, 56 corresponded to benign entities, and only one was found with lung carcinoma. On the other hand, from the 9 PB cases all of them (100%) were related to lung adenocarcinoma. We conclude that, even having a similar morphological structure, these aforementioned calcified structures we have observed in sputum smears have different and relevant clinical significance.

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“…Psammoma bodies are usually associated with a micropapillary and a papillary pattern. 1,[35][36][37][38][39] A psammoma body is characterized by the calcification of a concentric lamellate structure and constitutes a portion of an epithelial cluster in cytological specimens. 38…”

Section: Psammoma Bodymentioning

confidence: 99%