The Ocular Hypertension Treatment Study

Higginbotham, Eve J.; Gordon, Mae O.; Beiser, Julia A.; Drake, Michael V.; Bennett, George; Wilson, M. Roy; Kass, Michael A.

doi:10.1001/archopht.122.6.813

Cited by 143 publications

(35 citation statements)

References 34 publications

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“…29,30 Results from the Ocular Hypertension Treatment Study suggest that a greater occurrence of CVD may be linked to the higher incidence of glaucoma in African Americans. 31 …”

Section: Discussionmentioning

confidence: 99%

Differences in Ocular Blood Flow in Glaucoma Between Patients of African and European Descent

Siesky

Harris

Racette

et al. 2015

Journal of Glaucoma

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Purpose To investigate differences in ocular blood flow in individuals of African descent (AD) and European descent (ED) with open angle glaucoma (OAG). Patients and Methods A retrospective data analysis was performed on OAG patients of AD and ED who were previously examined for ocular blood flow within the Department of Ophthalmology at Indiana University School of Medicine. Data analysis included blood pressure, heart rate, visual fields, intraocular pressure, ocular perfusion pressure, and color Doppler imaging of retrobulbar vessels. Color Doppler imaging measurements were performed on ophthalmic, central retinal, and nasal and temporal short posterior ciliary arteries, with peak systolic (PSV) and end diastolic velocities (EDV) as well as the Pourcelot vascular resistive index calculated for each vessel. Two-sample t tests of unequal variance were performed with P values <0.05 considered statistically significant. Results OAG patients of AD had statistically significant lower retrobulbar blood flow values than patients of ED including lower ophthalmic artery PSV (P=0.0001), ophthalmic artery EDV (P=0.0008), central retinal artery PSV (P=0.01), temporal short posterior ciliary artery PSV (P=0.0037), and nasal short posterior ciliary artery PSV (P<0.0001). No significant differences were found in terms of intraocular pressure or visual field parameters. Conclusions Significantly lower blood flow values were identified in all retrobulbar blood vessels in AD compared with ED OAG patients. These findings suggest that the contribution of ocular blood flow to the disease process may be different in AD compared with ED OAG patients.

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“…29,30 Results from the Ocular Hypertension Treatment Study suggest that a greater occurrence of CVD may be linked to the higher incidence of glaucoma in African Americans. 31 …”

Section: Discussionmentioning

confidence: 99%

Differences in Ocular Blood Flow in Glaucoma Between Patients of African and European Descent

Siesky

Harris

Racette

et al. 2015

Journal of Glaucoma

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“…Intraocular pressure (IOP) is the major risk factor for glaucoma development and progression [1,2,3,4] and its thoughtful evaluation is therefore of crucial importance both at diagnosis and follow-up [5]. IOP reduction also reduces the effects of the disease on the visual field and optic nerve head [6,7], and as a consequence also the effects of IOP-lowering treatments need to be monitored over time.…”

Section: Introductionmentioning

confidence: 99%

“…There is evidence by multicenter, prospective randomized trials that reducing mean IOP is beneficial for reducing glaucoma progression [1,2,3,4]. Still, all these trials except one [3] relied on single IOP measurements performed at each visit, regardless of the large variations that frequently occur in glaucoma patients.…”

Section: Introductionmentioning

confidence: 99%

Short- and Long-Term Phasing of Intraocular Pressure in Stable and Progressive Glaucoma

et al. 2013

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Aims: To evaluate short- (ST) and long-term (LT) intraocular pressure (IOP) in patients with stable (SG) and progressive glaucoma (PG). Materials and Methods: Fifty-two patients with treated glaucoma received a baseline 24-hour IOP curve and, every 6 months for 2 years, office-hour curve plus visual field test. Based on field changes, they were divided into 24 SG and 28 PG. ST and LT IOP mean, peak and fluctuation (standard deviation of measurements) were calculated. Parameters determining progression were evaluated by logistic regression. Results: At ST, SG and PG, respectively, had mean IOP of 16.8 ± 2.2 and 15.3 ± 1.8 mm Hg; peak of 19.7 ± 3.3, 17.4 ± 2.3 mm Hg; fluctuation of 2.3 ± 1.2, and 1.6 ± 0.6 mm Hg. LT parameters did not change in SG, whereas a significant increase of mean (+1.0 ± 1.5 mm Hg, p = 0.05), peak (2.0 ± 2.4 mm Hg, p = 0.0002), and fluctuation (0.5 ± 1.1 mm Hg, p = 0.008) occurred in PG. Mean, peak, and fluctuation were correlated, except mean and fluctuation in the long term. Association with progression was shown for change in mean IOP between ST and LT, and ST peak. Conclusions: SG and PG may show different IOP parameters when intensively measured at baseline and follow-up. Mean IOP change between ST and LT periods and ST peak were the parameters associated with progression.

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“…[10,11,18,19] Results from the Ocular Hypertension Treatment Study (OHTS) suggest that increased rates of cardiovascular disease in AD persons may be linked to increased rates of glaucoma. [20] Our study investigated OAG patients of AD and ED with respect to retinal capillary blood flow and it’s impact on glaucomatous ONH structural progression over time in patients currently free from these diseases.…”

Section: Discussionmentioning

confidence: 99%

Optic nerve head morphology in glaucoma patients of African descent is strongly correlated to retinal blood flow

et al. 2014

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BACKGROUND/AIMS To examine the relationship between change in optic nerve head (ONH) morphology and retinal blood flow in patients with open-angle glaucoma (OAG) of African (AD) and European descent (ED) over three years. METHODS 112 patients with OAG (29 AD; 83 ED) underwent assessment of ONH morphology using Heidelberg retinal tomography (HRT-III) and retinal blood flow using confocal scanning laser Doppler. Repeated measures analysis of covariance was used to compare baseline and 3-year measurements and Pearson correlations were calculated to evaluate the relationships. RESULTS In OAG patients of AD, change in superior mean retinal blood flow was strongly, negatively correlated with change in cup/disc (C/D) area ratio (r=−0.78, p=0.020) and cup area (r=−0.75, p=0.0283) and strongly, positively correlated with change in rim area (r=0.74, p=0.0328) over three years. In OAG patients of AD, change in inferior mean retinal blood flow was strongly, negatively correlated with changes in C/D area ratio (r=−0.88, p=0.0156) and linear C/D ratio (r=−0.86, p=0.0265) over three years. In OAG patients of ED, these correlations were weak and did not reach statistical significance. DISCUSSION OAG patients of AD may have a stronger vascular component to their glaucoma pathophysiology than patients of ED.

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The Ocular Hypertension Treatment Study

Cited by 143 publications

References 34 publications

Differences in Ocular Blood Flow in Glaucoma Between Patients of African and European Descent

Differences in Ocular Blood Flow in Glaucoma Between Patients of African and European Descent

Short- and Long-Term Phasing of Intraocular Pressure in Stable and Progressive Glaucoma

Optic nerve head morphology in glaucoma patients of African descent is strongly correlated to retinal blood flow

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