The ocular manifestations of atopic dermatitis and rosacea

Eiseman, Andrew S.

doi:10.1007/s11882-006-0062-z

Cited by 20 publications

(11 citation statements)

References 21 publications

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“…The dermatological condition primarily affects the centre of the face, especially the cheeks, nose, chin and central forehead. Furthermore, ocular manifestations may be present, possibly occurring more frequently than previously presumed 2 . The earliest and not rarely predominant complaints linked to rosacea are intermittent, central facial flushing and erythema.…”

Section: Introductionmentioning

confidence: 99%

Current topical and systemic approaches to treatment of rosacea

Hc¹,

Schöllmann

2009

Acad Dermatol Venereol

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Rosacea is a common, often overlooked, chronic facial dermatosis characterized by intermittent periods of exacerbation and remission. Clinical subtypes and grading of the disease have been defined in the literature. On the basis of a genetic predisposition, there are several intrinsic and extrinsic factors possibly correlating with the phenotypic expression of the disease. Although rosacea cannot be cured, there are several recommended treatment strategies appropriate to control the corresponding symptoms/signs. In addition to adequate skin care, these include topical and systemic medications particularly suitable for the papulopustular subtype of rosacea with moderate to severe intensity. The most commonly used and most established therapeutic regimens are topical metronidazole and topical azelaic acid as well as oral doxycycline. Conventionally, 100-200 mg per day have been used. Today also a controlled release formulation is available, delivering 40 mg per day using non-antibiotic, anti-inflammatory activities of the drug. Anti-inflammatory dose doxycycline in particular allows for a safe and effective short-and long-term therapy of rosacea. Topical metronidazole and topical azelaic acid also appear to be safe and effective for short-term use. There are indications that a combined therapy of anti-inflammatory dose doxycycline and topical metronidazole could possibly have synergy effects. Further interesting therapy options for the short-and long-term therapy of rosacea could be low-dose minocycline and isotretinoin; however, too little data are available with regard to the effectiveness, safety, optimal dosage and appropriate length of treatment for these medications to draw final conclusions.

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Section: Introductionmentioning

confidence: 99%

Current topical and systemic approaches to treatment of rosacea

Hc¹,

Schöllmann

2009

Acad Dermatol Venereol

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“…The earliest symptoms associated with rosacea are intermittent central facial flushing and erythema. Furthermore, the disease may be linked to ocular manifestations [78]. Until today, the pathogenesis of rosacea is not known in detail, yet evidence has been accumulating that rosacea with its common symptoms, such as inflammatory lesions, erythema, teleangiectasia, phymatous changes and ocular symptoms, is of inflammatory nature [79].…”

Section: From Bedside To Bench: the Presentmentioning

confidence: 99%

Antimicrobial Peptides and Skin: A Paradigm of Translational Medicine

Körting

Schöllmann²,

Stauss-Grabo³

et al. 2012

Skin Pharmacol Physiol

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Antimicrobial peptides (AMPs) are small, cationic, amphiphilic peptides with broad-spectrum microbicidal activity against both bacteria and fungi. In mammals, AMPs form the first line of host defense against infections and generally play an important role as effector agents of the innate immune system. The AMP era was born more than 6 decades ago when the first cationic cyclic peptide antibiotics, namely polymyxins and tyrothricin, found their way into clinical use. Due to the good clinical experience in the treatment of, for example, infections of mucus membranes as well as the subsequent understanding of mode of action, AMPs are now considered for treatment of inflammatory skin diseases and for improving healing of infected wounds. Based on the preclinical findings, including pathobiochemistry and molecular medicine, targeted therapy strategies are developed and first results indicate that AMPs influence processes of diseased skin. Importantly, in contrast to other antibiotics, AMPs do not seem to propagate the development of antibiotic-resistant micro-organisms. Therefore, AMPs should be tested in clinical trials for their efficacy and tolerability in inflammatory skin diseases and chronic wounds. Apart from possible fields of application, these peptides appear suited as an example of the paradigm of translational medicine for skin diseases which is today seen as a ‘two-way road’ – from bench to bedside and backwards from bedside to bench.

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“…The main symptom is conjunctival injection, which is sometimes accompanied by chalazion or episcleritis. Rosacea patients should therefore be seen by an ophthalmologist early in the disease course [100]. …”

Section: Inflammatory Conditionsmentioning

confidence: 99%

Cutaneous lesions of the nose

Sand

Thrandorf

et al. 2010

Head Face Med

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Skin diseases on the nose are seen in a variety of medical disciplines. Dermatologists, otorhinolaryngologists, general practitioners and general plastic and dermatologic surgeons are regularly consulted regarding cutaneous lesions on the nose. This article is the second part of a review series dealing with cutaneous lesions on the head and face, which are frequently seen in daily practice by a dermatologic surgeon. In this review, we focus on those skin diseases on the nose where surgery or laser therapy is considered a possible treatment option or that can be surgically evaluated.

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The ocular manifestations of atopic dermatitis and rosacea

Cited by 20 publications

References 21 publications

Current topical and systemic approaches to treatment of rosacea

Current topical and systemic approaches to treatment of rosacea

Antimicrobial Peptides and Skin: A Paradigm of Translational Medicine

Cutaneous lesions of the nose

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