Anthropogenic activities increase methane emissions, contributing to greenhouse gas levels and adversely affecting the environment. Abandoned oil and gas wells potentially leak methane, but data are limited. We analyze methane emissions from abandoned wells (n = 179) in the Cherokee Platform in Oklahoma, a previously unaccounted basin, and compare emissions factors (EFs) to those in the Greenhouse Gas Inventory. We compare the contribution of various characteristics to the propensity for leakage. Higher emissions were observed with shallower wells and with unplugged wells. Plugged wells (n = 20) had an average EF of 96 ± 429 g/day and 65 ± 294 g/day for unplugged wells (n = 159). The majority of wells had no detectable leak. We calculated ethane EFs based on geochemical analysis of gas samples, finding higher EFs for unplugged (1.2 ± 5.5 g/day) versus plugged (0.9 ± 4.6 g/day) wells. The data indicate that in addition to the location of abandoned wells, physical characteristics are necessary to consider in estimating methane emissions. Plain Language Summary The Greenhouse Gas Inventory (GHGI) is a compendium of all known intentional and unintentional sources of greenhouse gas emissions from the United States. Although the GHGI catalogues emissions from many individual leakage points, such as pipelines or abandoned wells, the latter have only been recently added to the GHGI. The amount of data collected and used for analysis is very small and geographically limited compared to the vast number of abandoned wells in the United States. This study examines abandoned wells in Oklahoma, a previously unstudied region, and compares the leakage rates with data in the GHGI. Geographic locations, well plugging statuses, and well depths are important factors that influence leakage rates. This new analysis will aid in remediation efforts as wells in more leakage-prone regions can be prioritized for well plugging and environmental mitigation, thereby decreasing greenhouse gas emissions.