The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large‐scale resting‐state functional brain networks in aging

Deery, Hamish A; Paolo, Robert Di; Moran, Chris; Egan, Gary F.; Jamadar, Sharna

doi:10.1111/psyp.14159

Cited by 70 publications

(72 citation statements)

References 380 publications

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“…While on one hand the limitation of the current study is that we only examined between network connections, on the other hand several theories of cognitive ageing explicitly address changes in functional correlations between functional networks associated with either preservation or decline in cognitive performance in ageing. Specifically, it has been suggested that processes such as compensation and dedifferentiation both might be accompanied by stronger correlations among functionally unrelated networks or weaker anti-correlations among competing networks (Malagurski et al, 2020a,b; Deery et al, 2023). In this context the default mode network is of particular interest as the existing evidence points to anti-correlations between the default mode network and various other networks including fronto-parietal networks at rest and during task performance in young healthy participants (Greicius et al, 2003; Fox et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Modelling cognitive outcomes in the UK Biobank: education, noradrenaline and frontoparietal networks

Bravo-Merodio,

Williams,

Russ

et al. 2023

Preprint

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Cognitive reserve measured by proxies of life experiences is thought to account for the heterogeneity in cognitive ageing. One hypothesis is that cognitively enriched environments acting on the noradrenergic system strengthen the right fronto-parietal networks to facilitate cognitive reserve and maintain cognition throughout the lifetime. We used machine learning and mediation analysis to model interactions between neurobiological features (genetic variants in noradrenergic signalling, structural and functional fronto-parietal connectivity measures) and cognitive reserve (by proxy of education) on cognitive outcomes (general cognitive ability score) in the ageing UK Biobank cohort. We show that: (1) interactions between education and neurobiological variables more fully explain general cognitive ability than either factor alone; (2) among the examined neurobiological features, measures of fronto-parietal connectivity are the strongest mediators of the effect of education on cognitive outcomes. In particular, our findings point to two between-networks connectivity measures representing, connections linking the default mode network with the right fronto-parietal network, and with the executive control network as the key mediators between cognitively enriched environments and cognitive outcomes.

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Section: Discussionmentioning

confidence: 99%

Modelling cognitive outcomes in the UK Biobank: education, noradrenaline and frontoparietal networks

Bravo-Merodio,

Williams,

Russ

et al. 2023

Preprint

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“…Given the continuous aging of the world population, the question to prevent the degradation of cognitive abilities linked to age, and, notably, of memory capacities, is of ever-increasing importance that requires constant therapeutic research. Several decades of preclinical investigations have shown that cognitive impairment associated with physiological or pathological aging is the result of functional deregulation in brain neural networks [ 66 , 67 , 68 ]. The NMDAR subtype of glutamate receptors is critical for the expression of functional plasticity at synapses such as long-term potentiation, which is viewed as the molecular basis of memory formation [ 62 , 69 , 70 , 71 , 72 ], and data have accumulated to show that the expression and/or activity of NMDARs are impacted by age [ 8 , 11 , 12 , 73 ].…”

Section: Discussionmentioning

confidence: 99%

Improved NMDA Receptor Activation by the Secreted Amyloid-Protein Precursor-α in Healthy Aging: A Role for D-Serine?

Billard

Freret

2022

IJMS

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Impaired activation of the N-methyl-D-aspartate subtype of glutamate receptors (NMDAR) by D-serine is linked to cognitive aging. Whether this deregulation may be used to initiate pharmacological strategies has yet to be considered. To this end, we performed electrophysiological extracellular recordings at CA3/CA1 synapses in hippocampal slices from young and aged mice. We show that 0.1 nM of the soluble N-terminal recombinant fragment of the secreted amyloid-protein precursor-α (sAPPα) added in the bath significantly increased NMDAR activation in aged but not adult mice without impacting basal synaptic transmission. In addition, sAPPα rescued the age-related deficit of theta-burst-induced long-term potentiation. Significant NMDAR improvement occurred in adult mice when sAPPα was raised to 1 nM, and this effect was drastically reduced in transgenic mice deprived of D-serine through genetic deletion of the synthesizing enzyme serine racemase. Altogether, these results emphasize the interest to consider sAPPα treatment targeting D-serine-dependent NMDAR deregulation to alleviate cognitive aging.

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“…During aging both changes in conductive tissue properties (e.g. (Mohammed et al, 2017; Thomas et al, 2018)) and functional connectivity occur (Deery et al, 2023). Hypothetically, an interaction between several factors that differently affect MEG and EEG (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…During aging both changes in conductive tissue properties (e.g. (Mohammed et al, 2017;Thomas et al, 2018)) and functional connectivity occur (Deery et al, 2023).…”

Section: Differences In Aperiodic Activity Between Magnetic and Elect...mentioning

confidence: 99%

Age-related changes in “cortical” 1/f dynamics are linked to cardiac activity

Schmidt

Danböck

Trinka

et al. 2022

Preprint

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The power of electrophysiologically measured cortical activity decays 1/fX. The slope of this decay (i.e. the spectral exponent) is modulated by various factors such as age, cognitive states or psychiatric/neurological disorders. Interestingly, a mostly parallel line of research has shown similar effects for the spectral exponent in the electrocardiogram (ECG). This raises the question whether these bodywide changes in spectral exponents are independent or if the 'cortically' measured decay in power is explained by cardiac activity captured by cortical sensors (via volume conduction). Focusing on well-established age-related changes in spectral exponents, we analyzed a total of 1282 recordings of magnetoencephalography (MEG) resting state measurements with concurrent ECG in an age-diverse sample. We show that age-related changes of the spectral exponent of neural power spectra are largely explained by cardiac activity. Our results raise concerns when interpreting aperiodic activity as 'cortical' in absence of ECG recordings.

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The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large‐scale resting‐state functional brain networks in aging

Cited by 70 publications

References 380 publications

Modelling cognitive outcomes in the UK Biobank: education, noradrenaline and frontoparietal networks

Modelling cognitive outcomes in the UK Biobank: education, noradrenaline and frontoparietal networks

Improved NMDA Receptor Activation by the Secreted Amyloid-Protein Precursor-α in Healthy Aging: A Role for D-Serine?

Age-related changes in “cortical” 1/f dynamics are linked to cardiac activity

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