The Olfactory System

Shipley, Michael T.; Ennis, Matthew; Puché, Adam C.

doi:10.1007/978-1-60327-455-5_38

Cited by 41 publications

(39 citation statements)

References 411 publications

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“…Interneurons in the OB GL are heterogeneous in their morphology, neurochemical phenotype, and synaptic properties (Shipley et al, 2004;Kosaka and Kosaka, 2005;Parrish-Aungst et al, 2007), whereas interneurons in the GCL, mostly represented by GABAergic granule cells, are more homogeneous. Little is known about the functional significance of the diversity in neurotransmitter/peptide for olfactory signal processing, and it is unclear whether the different chemically coded subclasses of cells are generated in specific time windows during development or in the adult.…”

Section: Selective Neurochemical Classes Of Periglomerular Interneuromentioning

confidence: 99%

“…3E). Based on their morphology, these cells could be ascribed to nongranule cells types such as Blanes cells and/or Golgi cells, which are present in low density in the GCL of the adult OB (for review, see Shipley et al, 2004). These neurons, found in the large majority of animals transplanted with embryonic cells independently from the host age, were only occasionally observed with neonatal and adult donors.…”

Section: The Majority Of Transplanted Egfp Cells Become Periglomerulamentioning

confidence: 99%

“…SVZ-derived precursors migrate tangentially along the rostral migratory stream (RMS) to the OB, where they differentiate into local interneurons, within the granule (GCL) and glomerular (GL) layers (Luskin, 1993;Lois and Alvarez-Buylla, 1994). Interneurons of the GL and GCL modulate the activity of major output neurons in the OB and play essential roles in olfactory information processing (for review, see Shipley et al, 2004). Functional integration of newly generated neurons into the adult OB circuitry has been recently demonstrated (Belluzzi et al, 2003;Carleton et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…OB interneurons consist of a wide variety of phenotypes that differ in their spatial distribution, neurochemistry, structural features, and synaptic properties (Kosaka et al, 1998;Shipley et al, 2004;Kosaka and Kosaka, 2005;Parrish-Aungst et al, 2007;Pressler and Strowbridge, 2006). Major categories of local OB interneurons are granule (GC) and periglomerular (PG) cells.…”

Section: Introductionmentioning

confidence: 99%

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Generation of Distinct Types of Periglomerular Olfactory Bulb Interneurons during Development and in Adult Mice: Implication for Intrinsic Properties of the Subventricular Zone Progenitor Population

Marchis

Bovetti²,

Carletti³

et al. 2007

J. Neurosci.

157

143

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The subventricular zone (SVZ) of the lateral ventricle develops from residual progenitors of the embryonic lateral ganglionic eminence (LGE) and maintains neurogenic activity throughout life. Precursors from LGE/SVZ migrate to the olfactory bulb (OB) where they differentiate into local interneurons, principally in the granule layer and glomerular layer (GL). By in situ dye labeling, we show that neonatal and adult SVZ progenitors differentially contribute to neurochemically distinct types of periglomerular interneurons in the GL. Namely, calbindin-positive periglomerular cells are preferentially generated during early life, whereas calretinin-and tyrosine hydroxylase-expressing neurons are mainly produced at later ages. Furthermore, homochronic/heterochronic transplantation demonstrates that progenitor cells isolated from the LGE or SVZ at different stages (embryonic day 15 and postnatal days 2 and 30) engraft into the SVZ of neonatal or adult mice, migrate to the OB, and differentiate into local interneurons, including granule and periglomerular cells as well as other types of interneurons. The total number of integrated cells and the relative proportion of granule or periglomerular neurons change, according to the donor age, whereas they are weakly influenced by the recipient age. Analysis of the neurochemical phenotypes acquired by transplanted cells in the GL shows that donor cells of different ages also differentiate according to their origin, regardless of the host age. This suggests that progenitor cells at different ontogenetic stages are intrinsically directed toward specific lineages. Neurogenic processes occurring during development and in adult OB are not equivalent and produce different types of periglomerular interneurons as a consequence of intrinsic properties of the SVZ progenitors.

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Section: Selective Neurochemical Classes Of Periglomerular Interneuromentioning

confidence: 99%

Section: The Majority Of Transplanted Egfp Cells Become Periglomerulamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Generation of Distinct Types of Periglomerular Olfactory Bulb Interneurons during Development and in Adult Mice: Implication for Intrinsic Properties of the Subventricular Zone Progenitor Population

Marchis

Bovetti²,

Carletti³

et al. 2007

J. Neurosci.

157

143

View full text Add to dashboard Cite

show abstract

“…Olfactory receptor neurons (ORNs) are continuously generated throughout life, and dysosmia is often caused by damage to the olfactory pathway, especially the ORNs (Shipley et al, 2008). Olfactory ensheathing cells (OECs) are a special type of glial cells that are known as the only cells that are capable of sustainable regeneration of ORNs (Raisman and Li, 2007).…”

Section: Introductionmentioning

confidence: 99%

Olfactory mucosal microstructural changes in a rat model of acute rhinosinusitis with dysosmia

Liu

2014

Genet. Mol. Res.

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ABSTRACT. This study aimed to examine olfactory mucosal changes in a rat model of acute rhinosinusitis and to determine how acute rhinosinusitis induces dysosmia. Total 100 rats were divided into the experimental (N = 80) and control (N = 20) groups. An acute rhinosinusitis model was established in the experimental rats. From the experimental group, 20 rats each were sacrificed at 1, 2, 3, or 4 weeks. The control group was sacrificed at 1 week without inoculation. Olfaction was tested by the buried food pellet test before killing the rats, and the duration until the pellet was recorded and analyzed by a statistical software program. Mature olfactory receptor neurons (ORNs) and olfactory ensheathing cells (OECs) were examined. The durations spent by the experimental group in the BFPT were 402.9 ± 9.3, 453.7 ± 7.3, 351.9 ± 8.9, and 278.7 ± 8.1 s at 1, 2, 3, and 4 weeks, respectively. These durations were greater than that of the control group (178.3 ± 6.6 s), and the difference was statistically significant (P < 0.01). A reduction in ORNs and thinning of the epithelium were detected in the experimental group, most notably in the 2nd week and less in the fourth week. OECs were reduced in the 1st week, increased in the 2nd week, and almost completely recovered in the fourth week. In addition, some growing OECs were detected in the experimental group. Acute rhinosinusitis decreased both the mature ORNs and OECs, but OECs increased faster than the ORNs.

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Expression of prokineticins and their receptors in the adult mouse brain

Cheng

Leslie

Zhou

2006

J of Comparative Neurology

109

118

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Prokineticins are a pair of regulatory peptides that have been shown to play important roles in gastrointestinal motility, angiogenesis, circadian rhythms, and, recently, olfactory bulb neurogenesis. Prokineticins exert their functions via activation of two closely related G-protein-coupled receptors. Here we report a comprehensive mRNA distribution for both prokineticins (PK1 and PK2) and their receptors (PKR1 and PKR2) in the adult mouse brain with the use of in situ hybridization. PK2 mRNA is expressed in discrete regions of the brain, including suprachiasmatic nucleus, islands of Calleja and medial preoptic area, olfactory bulb, nucleus accumbens shell, hypothalamic arcuate nucleus, and amygdala. PK1 mRNA is expressed exclusively in the brainstem, with high abundance in the nucleus tractus solitarius. PKR2 mRNA is detected throughout the brain, with prominent expression in olfactory regions, cortex, thalamus and hypothalamus, septum and hippocampus, habenula, amygdala, nucleus tractus solitarius, and circumventricular organs such as subfornical organ, median eminence, and area postrema. PKR2 mRNA is also detected in mammillary nuclei, periaqueductal gray, and dorsal raphe. In contrast, PKR1 mRNA is found in fewer brain regions, with moderate expression in the olfactory regions, dentate gyrus, zona incerta, and dorsal motor vagal nucleus. Both PKR1 and PKR2 are also detected in olfactory ventricle and subventricular zone of the lateral ventricle, both of which are rich sources of neuronal precursors. These extensive expression patterns suggest that prokineticins may have a broad array of functions in the central nervous system, including circadian rhythm, neurogenesis, ingestive behavior, reproduction, and autonomic function.

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The Olfactory System

Cited by 41 publications

References 411 publications

Generation of Distinct Types of Periglomerular Olfactory Bulb Interneurons during Development and in Adult Mice: Implication for Intrinsic Properties of the Subventricular Zone Progenitor Population

Generation of Distinct Types of Periglomerular Olfactory Bulb Interneurons during Development and in Adult Mice: Implication for Intrinsic Properties of the Subventricular Zone Progenitor Population

Olfactory mucosal microstructural changes in a rat model of acute rhinosinusitis with dysosmia

Expression of prokineticins and their receptors in the adult mouse brain

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