The Olig family affects central nervous system development and disease

Tan, Botao; Yu, Jing; Yin, Ying; Jia, Gongwei; Jiang, Wei; Yu, Lehua

doi:10.4103/1673-5374.128232

Cited by 12 publications

(2 citation statements)

References 77 publications

(132 reference statements)

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“… 12 Knocking out Olig1 and Olig2 individually or together affected differentiation and maturation of OLs, suggesting functional overlap in the CNS. 10 , 13 , 14 Until now, the role of Olig2 during development of spinal cord attracted more attention. However, studies investigating the expression and function of Olig1 in development and disease are limited.…”

Section: Introductionmentioning

confidence: 99%

Olig1 expression pattern in neural cells during rat spinal cord development

Zhang

Shen

et al. 2016

NDT

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PurposeOur purpose was to systematically investigate the expression pattern and role of Olig1 in neural cells during rat spinal cord development.Animals and methodsSpinal cord tissues were dissected from Sprague–Dawley rats at embryonic day 14.5 (E14.5) and E18.5, postnatal day 0 (P0), P3, P7, postnatal 2 weeks (P2W), P4W, and adults (more than 2 months after birth), respectively. The expression of Olig1 was determined by Western blot and immunostaining. To observe expression of Olig1 in different neural cell types, a double immunohistochemical staining was performed using antibodies against Olig1 with O4, β-tubulin, glial fibrillary acidic protein (GFAP), and myelin basic protein, respectively.ResultsThe expression of Olig1 protein shows a significant level change in rat spinal cord at different developmental time points. Starting with E14.5, the expression gradually increased and peaked at E18.5. Olig1 decreased gradually from P3 and reached its lowest level on P7. However, interestingly, the Olig1 expression increased again from P2W, until adulthood. Olig1 was coexpressed with O4-positive oligodendrocyte progenitor cells (OPCs) and β-tubulin-positive neurons at all time points during development. Olig1 was also coexpressed transiently with GFAP-positive astrocytes at only E14.5. Olig1 was localized in the cytoplasm of O4- and β-tubulin-positive cells during the period from E14.5 to adult.ConclusionThe expression of Olig1 in OPCs and neurons at all time points during development and in astrocytes at E14.5 suggests that Olig1 may play an important role in the generation and maturation of specific neural cells during development of spinal cord. Our results contribute to understanding the mechanism underlying developmental regulation of neural cells by Olig1.

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Section: Introductionmentioning

confidence: 99%

Olig1 expression pattern in neural cells during rat spinal cord development

Zhang

Shen

et al. 2016

NDT

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“…However, the limitations of NSCs such as insufficient proliferation, failing of differentiating towards desired cell types, and not being able to migrate efficiently make it still a long way of utilizing them in clinical practice [2]. It was pointed out that biological behavior of NSCs was controlled by various intrinsic characteristics and extrinsic signals [3–5]. Among these, lipid mediators would be one of the undervalued candidates in regulating NSCs proliferation, migration, and differentiation.…”

Section: Introductionmentioning

confidence: 99%

Effects of FTY720 (Fingolimod) on Proliferation, Differentiation, and Migration of Brain‐Derived Neural Stem Cells

Tan

Luo

Yan

et al. 2016

Stem Cells International

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Insufficient proliferation, differentiation, and migration are the main pitfalls of neural stem cells (NSCs) in reparative therapeutics for the central nervous system (CNS) diseases. The potent lipid mediator sphingosine-1-phosphate (S1P) regulates cells' biological behavior broadly in the CNS. However, the effects of activating S1P on NSCs are not quite clear. In the current study, FTY720 (Fingolimod), an analog of S1P, was employed to induce the proliferation, differentiation, and migration of cultured brain-derived NSCs. The results indicated that proliferation and migration ability of NSCs were promoted by FTY720. Though we observed no obvious neuron prefers differentiation of NSCs, there were more protoplasmic astrocytes developed in the presence of certain concentration of FTY720. This work gives more comprehensive understanding of how FTY720 affects NSCs.

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Thyroid hormone transporter Mct8/Oatp1c1 deficiency compromises proper oligodendrocyte maturation in the mouse CNS

Mayerl

Heuer

2023

Neurobiology of Disease

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The Olig family affects central nervous system development and disease

Cited by 12 publications

References 77 publications

Olig1 expression pattern in neural cells during rat spinal cord development

Olig1 expression pattern in neural cells during rat spinal cord development

Effects of FTY720 (Fingolimod) on Proliferation, Differentiation, and Migration of Brain‐Derived Neural Stem Cells

Thyroid hormone transporter Mct8/Oatp1c1 deficiency compromises proper oligodendrocyte maturation in the mouse CNS

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