2023
DOI: 10.3390/ijms24097741
|View full text |Cite
|
Sign up to set email alerts
|

The Oligostilbene Gnetin H Is a Novel Glycolysis Inhibitor That Regulates Thioredoxin Interacting Protein Expression and Synergizes with OXPHOS Inhibitor in Cancer Cells

Abstract: Since aerobic glycolysis was first observed in tumors almost a century ago by Otto Warburg, the field of cancer cell metabolism has sparked the interest of scientists around the world as it might offer new avenues of treatment for malignant cells. Our current study claims the discovery of gnetin H (GH) as a novel glycolysis inhibitor that can decrease metabolic activity and lactic acid synthesis and displays a strong cytostatic effect in melanoma and glioblastoma cells. Compared to most of the other glycolysis… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
1
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(1 citation statement)
references
References 67 publications
(113 reference statements)
0
1
0
Order By: Relevance
“…The novel glycolytic inhibitor gnetin H (GH) directly controls the gene involved in cellular glucose homeostasis via a cytostatic effect in melanoma and glioblastoma cells. Moreover, used in combination with phenformin, a mitochondrial complex I inhibitor, it is a compounds for therapy-resistant tumours, inducing metabolic catastrophe and apoptosis in cancer cells [ 7 ]. However, apoptosis-inducing anticancer agents such as doxorubicin (DOX) induced cardiovascular toxicity caused by mitochondrial dysfunction.…”
mentioning
confidence: 99%
“…The novel glycolytic inhibitor gnetin H (GH) directly controls the gene involved in cellular glucose homeostasis via a cytostatic effect in melanoma and glioblastoma cells. Moreover, used in combination with phenformin, a mitochondrial complex I inhibitor, it is a compounds for therapy-resistant tumours, inducing metabolic catastrophe and apoptosis in cancer cells [ 7 ]. However, apoptosis-inducing anticancer agents such as doxorubicin (DOX) induced cardiovascular toxicity caused by mitochondrial dysfunction.…”
mentioning
confidence: 99%