The one‐eye trial and fellow eye response to prostaglandin analogues

Dayanir, Volkan; Çakmak, Harun; Berkit, Ilker

doi:10.1111/j.1442-9071.2008.01698.x

Cited by 18 publications

(15 citation statements)

References 23 publications

(54 reference statements)

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“…A retrospective study by Dayanir et al [4] reported that there was a significant correlation of the IOP response in the initial eye (adjusted IOP change) and that of the subsequent eye (unadjusted IOP change) in patients with high tension glaucoma, whereas this relationship was not significant in patients with normal tension glaucoma. Another retrospective study documented that a correlation between the two eyes was higher when using adjusted IOP changes [5].…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of a Monocular Drug Trial in Normal-Tension Glaucoma

Lee

Hwang

Kim

2012

Korean J Ophthalmol

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PurposeTo evaluate the efficacy of a monocular drug trial in eyes with normal-tension glaucoma (NTG).MethodsThis prospective study enrolled 74 patients with NTG. The monocular drug trial was started using latanoprost 0.005% for one week. If the intraocular pressure (IOP) reduction was greater than 15%, the same medication was administered to both eyes for one month. The unadjusted change and adjusted change (the change in the treated eye minus the change in the contralateral eye) in IOP were evaluated, and the predictors of IOP response were analyzed by multivariate linear regression.ResultsAmong the initial 74 patients, 31 (41.9%) were included; others were excluded because they did not meet the requisite conditions. The most significant predictors of IOP response in the initial eye and subsequent eye were the baseline IOPs in both eyes (β = 0.907, 0.771, respectively). The adjusted change in IOP of the initial eye had greater association (β = 0.589) with the IOP after monocular trial in the initial eye than that of unadjusted IOP change (β = 0.279). The adjusted change in IOP also had greater predictability (β = 0.348) for IOP after monocular trial in the subsequent eye than that of the unadjusted IOP change (β = 0.090).ConclusionsAlthough the monocular trial in NTG patients had limited efficacy due to its stringent conditions, it was useful for evaluating the IOP response in the initial eye and for predicting the IOP response in the subsequent eye.

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Section: Discussionmentioning

confidence: 99%

The Efficacy of a Monocular Drug Trial in Normal-Tension Glaucoma

Lee

Hwang

Kim

2012

Korean J Ophthalmol

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“…If office hours diurnal IOP measurements was judged to be high for the patient then glaucoma medications were started as for any open angle glaucoma patient. 7 At the last follow-up, an IOP ≤18 mmHg without any antiglaucoma drops was considered as a complete success, an IOP ≤18 mmHg with one or more antiglaucoma drops was considered as a qualified success and an IOP >18 mmHg despite antiglaucoma drops or need for glaucoma surgery was considered as a failure.…”

Section: Methodsmentioning

confidence: 99%

“…So nuç lar: APAKG'da son preoperatif değerlendirmedeki ortalama İOB (%95 CI), antiglokomatöz ilaç sayısı ve Snellen görme keskinliği 30,9±15,6 mmHg (23,0-38,0), 2,6±1,4 kutu ve 0,4±0,2 sıradan son takipte 15,5±3,9mm Hg (p<0,000, 13,8-17,0), 0,6±0,9 (p<0,000) kutu ve 0,6±0,3 (p=0.001) sıra olarak değişti. KPAKG'da son preoperatif değerlendirmedeki aynı parametreler 18, 0±7,8 mmHg (15,[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]8), 1,6±1,1 kutu ve 0,5±0,2 sıradan son takipte 14, 7±3,6 mmHg (p<0,023,13,[4][5][6][7][8][9][10][11][12][13][14][15][16]0), 0,5±0,8 (p<0,000) kutu ve 0,6±0,3 (p=0,007) sıra olarak değişti. APAKG ve KPAKG'u için ortalama takip süresi (95% CI) sırasıyla 554±646 (268-841) ve 747±820 (438-1041) gün idi.…”

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Primer Açı Kapanması Glokomunda Fakoemülsifikasyon Cerrahisinin İntraoküler Basınç Üzerine Etkisi

Dayanir¹,

Ozdemir²,

Kaplan³

et al. 2012

tjo

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Sum maryPur po se: To investigate whether primary phacoemulsification in acute primary angle closure glaucoma (APACG) and chronic primary angle closure glaucoma (CPACG) will lower intraocular pressure (IOP) or not. Ma te ri al and Met hod: This retrospective, non-comparative, consecutive, interventional case series includes 22 eyes of 20 patients with APACG and 31 eyes of 23 patients with CPACG. All eyes had undergone phacoemulsification surgery without any reference to the presence of cataract. Data about IOP, number of antiglaucoma medications and best corrected visual acuity (BCVA) were collected. Re sults: In APACG mean IOP (95% CI), number of antiglaucoma medications and Snellen visual acuity changed at last preoperative evaluation from 30.9±15.6 mmHg (23.0-38.0), 2.6±1.4 boxes and 0.4±0.2 lines to 15.5±3.9 mm Hg (p<0.000, 13.8-17.0), 0.6±0.9 boxes (p<0.000) and 0.6±0.3 lines (p=0.001) at last follow-up. Same parameters in CPACG changed from 18.0±7.8 mmHg (15.1-20.8), 1.6±1.1 boxes and 0.5±0.2 lines at last preoperative evaluation to 14.7±3.6 mmHg (p<0.023, 13.4-16.0), 0.5±0.8 boxes (p<0.000) and 0.6±0.3 lines (p=0.007) at last follow-up. Mean follow-up (95% CI) for APACG and CPACG were 554±646 (268-841) and 747±820 (438-1041) days respectively. In APACG and CPACG groups 19 eyes (86%) and 16 eyes (52%) had lower IOP respectively at last follow-up. 59% of the eyes with APACG and 61% of the eyes with CPACG were classified as complete success when it was defined as IOP ≤18mmHg without any antiglaucoma medications. Dis cus si on: Primary phacoemulsification without any reference to cataract is a safe and effective procedure in terms of IOP control and reducing the number of antiglaucoma drops in APACG and CPACG. (Turk J Ophthalmol 2012; 42: 438-42) Özet Amaç: Akut primer açı kapanması glokomu (APAKG) ve kronik primer açı kapanması glokomunda (KPAKG) primer fakoemülsifikasyonun intraoküler basıncı (İOB) düşürüp, düşürmeyeceğini araştırmak. Ge reç ve Yön tem: Bu retrospektif, karşılaştırmasız, ardışık, girişimsel vaka serisi APAKG'u olan 20 hastanın 22 gözünü ve KPAKG'u olan 23 hastanın 31 gözünü içermektedir. Kataraktın varlığından bağımsız olarak tüm gözlere fakoemülsifikasyon cerrahisi uygulanmıştır. İOB, antiglokomatöz ilaç sayısı ve en iyi düzeltilmiş görme keskinliği (EDGK) ile ilgili data elde edildi. So nuç lar: APAKG'da son preoperatif değerlendirmedeki ortalama İOB (%95 CI), antiglokomatöz ilaç sayısı ve Snellen görme keskinliği 30,9±15,6 mmHg (23,0-38,0), 2,6±1,4 kutu ve 0,4±0,2 sıradan son takipte 15,5±3,9mm Hg (p<0,000, 13,8-17,0), 0,6±0,9 (p<0,000) kutu ve 0,6±0,3 (p=0.001) sıra olarak değişti. KPAKG'da son preoperatif değerlendirmedeki aynı parametreler 18, 0±7,8 mmHg (15,[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]8), 1,6±1,1 kutu ve 0,5±0,2 sıradan son takipte 14, 7±3,6 mmHg (p<0,023,13,[4][5][6][7][8][9][10][11][12][13][14][15][16]0), 0,5±0,8 (p<0,000) kutu ve 0,6±0,3 (p=0,007) sıra olarak değişti. APAKG ve KPAKG'u için ortalama takip süresi (95% CI) sırasıyla 554±646...

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“…However, a recent study demonstrates the lack of correlation between IOP responses of fellow eyes to the same medication in a one-eye trial [4]. Some studies demonstrate that one-eye trials predict the amount of IOP reduction in the fellow eye only in high-tension glaucoma or in glaucoma suspects [5,6]. The results evaluating the use of one-eye trials have been varied, and the selection of subjects and methods of one-eye trials still need to be refined.…”

Section: Introductionmentioning

confidence: 96%