The Ongoing Debate Regarding Completion Thyroidectomy Versus Primary Thyroid Surgery for Low and Intermediate Differentiated Thyroid Carcinoma: A Meta-Analysis

Mirghani, Hyder; Albalawi, Ibrahim Altedlawi

doi:10.7759/cureus.12033

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…However, others reveal increased recurrent laryngeal nerve (RLN) injuries or hypoparathyroidism without differences in recurrence rates [14][15][16][17]. Other studies found no significantly different outcomes between TT and cT, but these conclusions also require more support [12,18,19]. Defining the optimal surgical strategy and timing remains actively debated to balance risks against prognosis [8,20,21], considering factors such as costs, anesthesia exposures, and patient preferences.…”

Section: Introductionmentioning

confidence: 99%

Initial versus Staged Thyroidectomy for Differentiated Thyroid Cancer: A Retrospective Multi-Dimensional Cohort Analysis of Effectiveness and Safety

Toraih,

Hussein,

Jishu

et al. 2024

Cancers

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The optimal surgical approach for differentiated thyroid cancer remains controversial, with debate regarding the comparative risks of upfront total thyroidectomy versus staged completion thyroidectomy following the initial lobectomy. This study aimed to assess the complication rates associated with these two strategies and identify the optimal timing for completion thyroidectomy using a multi-dimensional analysis of four cohorts: an institutional series (n = 148), the National Surgical Quality Improvement Program (NSQIP) database (n = 39,992), the TriNetX repository (n > 30,000), and a pooled literature review (10 studies, n = 6015). Institutional data revealed higher overall complication rates with total thyroidectomy (18.3%) compared to completion thyroidectomy (6.8%), primarily due to increased temporary hypocalcemia (10% vs. 0%, p = 0.004). The NSQIP analysis demonstrated that total thyroidectomy was associated with a 72% increased risk of transient hypocalcemia (p < 0.001) and a 25% increased risk of permanent hypocalcemia (p < 0.001). TriNetX data confirmed these findings and identified obesity and concurrent neck dissection as risk factors for complications. A meta-analysis showed that total thyroidectomy increased the rates of transient (RR = 1.63) and permanent (RR = 1.23) hypocalcemia (p < 0.001). Institutional and TriNetX data suggested that performing completion thyroidectomy between 1 and 6 months after the initial lobectomy minimized permanent complication rates compared to delays beyond 6 months. In conclusion, for differentiated thyroid cancer, total thyroidectomy is associated with higher risks of transient and permanent hypocalcemia compared to staged completion thyroidectomy. However, performing completion thyroidectomy within 1–6 months of the initial lobectomy may mitigate the risk of permanent complications. These findings can inform personalized surgical decision-making for patients with differentiated thyroid cancer.

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Section: Introductionmentioning

confidence: 99%

Initial versus Staged Thyroidectomy for Differentiated Thyroid Cancer: A Retrospective Multi-Dimensional Cohort Analysis of Effectiveness and Safety

Toraih,

Hussein,

Jishu

et al. 2024

Cancers

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“…Lo anterior se refiere a la a una colaboración de profesionales de la salud de varias especialidades que trabajan juntos para brindar el mejor tratamiento posible para un paciente con una afección particular. En el caso del cáncer de tiroides, un enfoque multidisciplinario implica la colaboración entre endocrinólogos, cirujanos, radiólogos, patólogos y oncólogos (Mirghani, H., & Albalawi II., 2020;Díez, J., & Galofré, J. 2021;Campenni et al, 2020;Zhao H. et al, 2021).…”

Section: Introductionunclassified

Importancia del manejo multidisciplinario en el paciente con cáncer de tiroides diferenciado

et al. 2023

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El cáncer de tiroides diferenciado (DTC) es un tipo de cáncer que afecta a la glándula tiroides y cuya prevalencia ha aumentado en los últimos años. El objetivo del presente trabajo es dar a conocer la importancia del enfoque terapéutico multidisciplinario en la resolución clínica de los pacientes con esta patología. La investigación es de tipo cualitativa-descriptiva, donde se realizó una revisión bibliográfica de artículos científicos en bases de datos de importancia médica. Los resultados indican que, aunque el DTC es diverso, en general tienen buen pronóstico y la mayoría de los pacientes con este tipo de cáncer pueden tratarse de manera multidisciplinar lo cual es eficaz. Cada especialista del equipo multidisciplinario aporta su experiencia y conocimiento para brindar un enfoque integral al tratamiento del cáncer de tiroides. Al trabajar juntos, el equipo puede garantizar que el paciente reciba la mejor atención posible, desde el diagnóstico hasta el control y la vigilancia continuos.

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Dynamic risk assessment in patients with differentiated thyroid cancer

Abelleira,

Jerkovich

2023

Rev Endocr Metab Disord

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The Ongoing Debate Regarding Completion Thyroidectomy Versus Primary Thyroid Surgery for Low and Intermediate Differentiated Thyroid Carcinoma: A Meta-Analysis

Cited by 4 publications

References 27 publications

Initial versus Staged Thyroidectomy for Differentiated Thyroid Cancer: A Retrospective Multi-Dimensional Cohort Analysis of Effectiveness and Safety

Initial versus Staged Thyroidectomy for Differentiated Thyroid Cancer: A Retrospective Multi-Dimensional Cohort Analysis of Effectiveness and Safety

Importancia del manejo multidisciplinario en el paciente con cáncer de tiroides diferenciado

Dynamic risk assessment in patients with differentiated thyroid cancer

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