The onion skin-like organization of the septum arises from multiple embryonic origins to form multiple adult neuronal fates

Wei, Bin; Huang, Zengjin; He, Shan; Sun, Congjian; You, Yun; Liu, F.; Yang, Zhengang

doi:10.1016/j.neuroscience.2012.07.016

Cited by 27 publications

(84 citation statements)

References 47 publications

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“…The distribution of the different molecular markers within the MS/vDB was consistent with its onion-like structure (Wei et al 2012). CaBP positive neurons are arranged in three bands, from the midline outward -PV, CR and CB.…”

Section: J-l)supporting

confidence: 66%

Central relaxin-3 receptor (RXFP3) activation increases ERK phosphorylation in septal cholinergic neurons and impairs spatial working memory

et al. 2016

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The medial septum/diagonal band (MS/DB) is a relay region connecting the hypothalamus and brainstem with the hippocampus, and both the MS/DB and dorsal/ventral hippocampus receive strong topographic GABA/peptidergic projections from the nucleus incertus of the pontine tegmentum. The neuropeptide relaxin-3, released by these neurons, is the cognate ligand for a G i/o -protein-coupled receptor, RXFP3, which is highly expressed within the MS/DB, and both

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Section: J-l)supporting

confidence: 66%

Central relaxin-3 receptor (RXFP3) activation increases ERK phosphorylation in septal cholinergic neurons and impairs spatial working memory

et al. 2016

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“…Postmitotic cholinergic neurons of the septum are thought to express ZIC1 and NKX2-1 ( Wei et al., 2012 ), leaving open the possibility that these cells originate outside the septum, upregulate ZIC4 postmitotically, and hence are labeled in Zic4-Cre mice. In order to temporally control the Cre activity, we generated Zic4-CreER T2 ;R26R-tdTomato transgenic mice and induced recombination at embryonic day (E)9.5 ( Figures S1 A and S1B).…”

Section: Resultsmentioning

confidence: 99%

NKX2-1 Is Required in the Embryonic Septum for Cholinergic System Development, Learning, and Memory

et al. 2017

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SummaryThe transcription factor NKX2-1 is best known for its role in the specification of subsets of cortical, striatal, and pallidal neurons. We demonstrate through genetic fate mapping and intersectional focal septal deletion that NKX2-1 is selectively required in the embryonic septal neuroepithelium for the development of cholinergic septohippocampal projection neurons and large subsets of basal forebrain cholinergic neurons. In the absence of NKX2-1, these neurons fail to develop, causing alterations in hippocampal theta rhythms and severe deficiencies in learning and memory. Our results demonstrate that learning and memory are dependent on NKX2-1 function in the embryonic septum and suggest that cognitive deficiencies that are sometimes associated with pathogenic mutations in NKX2-1 in humans may be a direct consequence of loss of NKX2-1 function.

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“…The embryonic subpallial septum is the source of the GABAergic and cholinergic projection neurons that will make up the medial and lateral divisions of the mature septum and the diagonal band nuclei . The progenitors of the septal anlage express pan‐subpallial transcription factors (Dlx, Ascl1, Olig2, Vax1) ; interestingly, the loss of Vax1 results in complete ablation of the septum while only partially depleting cells derived from other ventral proliferative regions, suggesting that this factor plays a key role in septal development .…”

Section: Septummentioning

confidence: 99%

Radial glia in the ventral telencephalon

García

Harwell

2017

FEBS Letters

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The ventral telencephalon is the developmental origin of the basal ganglia and the source of neuronal and glial cells that integrate into developing circuits in other areas of the brain. Radial glia in the embryonic subpallium give rise to an enormous diversity of mature cell types, either directly or through other transit-amplifying progenitors. Here, we review current knowledge about these subpallial neural stem cells and their progeny, focusing on the period of neurogenesis. We describe their cell biological features and the extrinsic and intrinsic molecular codes that guide their fate specification in defined temporal and spatial sequences. We also discuss the role of clonal lineage in the organization and specification of mature neurons.

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The onion skin-like organization of the septum arises from multiple embryonic origins to form multiple adult neuronal fates

Cited by 27 publications

References 47 publications

Central relaxin-3 receptor (RXFP3) activation increases ERK phosphorylation in septal cholinergic neurons and impairs spatial working memory

Central relaxin-3 receptor (RXFP3) activation increases ERK phosphorylation in septal cholinergic neurons and impairs spatial working memory

NKX2-1 Is Required in the Embryonic Septum for Cholinergic System Development, Learning, and Memory

Radial glia in the ventral telencephalon

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