The Onset of Clinical Manifestations in Inflammatory Bowel Disease Patients

Abstract

BACKGROUND: The diagnosis of inflammatory bowel disease is often delayed because of the lack of an ability to recognize its major clinical manifestations. OBJECTIVE: Our study aimed to describe the onset of clinical manifestations in inflammatory bowel disease patients. METHODS: A cross-sectional study. Investigators obtained data from interviews and the medical records of inflammatory bowel disease patients from a reference centre located in Brazil. RESULTS: A total of 306 patients were included. The mean time between onset of symptoms and diagnosis was 28 months for Crohn’s disease and 19 months for ulcerative colitis. The main clinical manifestations in Crohn’s disease patients were weight loss, abdominal pain, diarrhoea and asthenia. The most relevant symptoms in ulcerative colitis patients were blood in the stool, faecal urgency, diarrhoea, mucus in the stool, weight loss, abdominal pain and asthenia. It was observed that weight loss, abdominal pain and distension, asthenia, appetite loss, anaemia, insomnia, fever, nausea, perianal disease, extraintestinal manifestation, oral thrush, vomiting and abdominal mass were more frequent in Crohn’s patients than in ulcerative colitis patients. The frequencies of urgency, faecal incontinence, faeces with mucus and blood, tenesmus and constipation were higher in ulcerative colitis patients than in Crohn’s disease patients. The mean time from the onset of clinical symptoms to the diagnosis of Crohn’s disease was 37 months for patients with ileocolonic location, 26 months for patients with ileum location and 18 months for patients with colon location. In ulcerative colitis patients, the mean time from the onset of symptoms to diagnosis was 52 months for proctitis, 12 months for left-sided colitis and 12 months for extensive colitis. CONCLUSION: Ulcerative colitis presented a high frequency of intestinal symptoms, and Crohn’s disease showed a high frequency of systemic manifestations at the onset of manifestation. There was a long delay in diagnosis, but individuals with more extensive disease and more obvious symptoms showed a shorter delay.

Profiling Non-Coding RNA Levels With Clinical Classifiers in Pediatric Crohn’s Disease

“…Thermodynamic calculations, binding a nities, and base-pair modeling were conducted using IntaRNA version 2.3.0, in conjunction with Vienna RNA package 2.4.9 2,22,23 . Utilizing this server, possible interactions between target mRNAs such as mir-1244-2, mir-1244-3, mir-1244-4 and query RN7SL2 ncRNA were computed with parameters for the sliding window size set with 150, maximum length of unpaired region with 150, maximum distance of two paired bases with 100, the weight for ED values of target RNA and query RNA were set at 1, and the temperature was set at 37 degrees Celsius.…”

“…In ammatory Bowel Disease (IBD) is a disorder affecting the intestines with two prominent disease types; ulcerative colitis (UC) and Crohn's disease (CD), whereby UC is con ned mostly to the colonic mucosa with persistent chronic in ammation 1 and CD is a transmural disease affecting the entire gastrointestinal tract 2 . Rising incidence of IBD have been attributed to the gut-microbiome interactions, genetic predispositions, and environmental triggers 3 , but more recently attention has been placed on epigenetic mechanisms 4 .…”

Visceral obesity on chronic constipation, inflammation, immune function and cognitive function in patients with inflammatory bowel disease

“…Several studies proved that the prevalence of overweight or obesity for CD patients ranged from 40-52% in western countries 5,6 . These studies only evaluated body mass index (BMI) to de ne obesity and a threshold of obesity was de ned as BMI > 30 kg/m 2 . No published articles evaluate further into impact of visceral obesity based on computed tomography (CT) scans on clinical characteristics in the disease process of IBD patients, especially in Chinese population.…”

Impact of Visceral Obesity on Chronic Obstipation, Inflammation, Immune Function and Cognitive Function Among Patients with Inflammatory Bowel Disease

“…Constipation is a common symptom of IBD, diagnosed by having less than 3 bowel movements per week and / or di culty in bowel movements. More than 10% IBD patients had chronic constipation 2 . Obesity has gained attention for patients with IBD.…”

“…Several studies proved that the prevalence of overweight or obesity for CD patients ranged from 40% to 52% in western countries 5,6 . These studies only evaluated body mass index (BMI) to de ne obesity and a threshold of obesity was de ned as BMI > 30 kg/m 2 . No published articles evaluate further into impact of visceral obesity based on computed tomography (CT) scans on clinical characteristics in the disease process of IBD patients, especially in Chinese population.…”