1971
DOI: 10.1113/expphysiol.1971.sp002096
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The Onset of Functional Capacity in Fetal Guinea‐pig Parathyroid Glands

Abstract: Parathyroid tissue or pharyngeal pouch tissue containing the presumptive primordium of parathyroid III from embryonic guinea‐pigs has been explanted to the chick chorioallantoic membrane in contact with a piece of neonatal rat parietal bone. Histological study of the conjoined grafts, removed 4–7 days later, showed bone resorption, indicative of parathyroid secretory activity, at developmental ages of 23 days and older.

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Cited by 5 publications
(6 citation statements)
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“…Other possibilities are high calcium binding by fetal proteins or large quantities of citrate. The observed fall in fetal plasma calcium concentration between 16 and 18 days is coincident with the initial phase of skeletal calcification and resembles the findings in the guinea pig [Graham and Scothorne, 1970] [Graham andScothorne, 1970 and1971].…”
Section: Discussionsupporting
confidence: 54%
See 1 more Smart Citation
“…Other possibilities are high calcium binding by fetal proteins or large quantities of citrate. The observed fall in fetal plasma calcium concentration between 16 and 18 days is coincident with the initial phase of skeletal calcification and resembles the findings in the guinea pig [Graham and Scothorne, 1970] [Graham andScothorne, 1970 and1971].…”
Section: Discussionsupporting
confidence: 54%
“…This paper presents a study of maternal and fetal levels, from a relatively early stage in gestation, in another species. The rabbit was chosen since there is already some evidence that fetal levels are lower than maternal at 21-23 days of gestation [McIsaac, 1927;Economou-Mavrou and McCance, 1958].The stage in gestation when the homeostatic mechanism for calcium becomes mature in the fetus has not yet been identified, although there is experimental evidence that the parathyroid can elaborate hormone early in embryonic development [Scothorne, 1964: Graham andScothorne, 1971]. In late gestation, when fetal calcium levels are higher than maternal, the fetal level remains constant when the level in the mother is elevated by infusion of calcium chloride Wolkoff, 1967: Greeson et al, 1968].…”
mentioning
confidence: 99%
“…Histologic studies indicate that fetal human parathyroid glands at midpregnancy have the typical features of active adult glands, including the presence of vesicular cells (19,20). In vitro studies strongly suggest that in the first third of gestation secretory activity is present in human, sheep, guinea pig, and chicken fetal parathyroid glands, as indicated by the ability of the glands to induce bone resorption when explanted in close contact with neonatal rat parietal bone (21)(22)(23). Further evidence' for the presence of circulating parathyroid hormone in the fetus is that a fall in plasma Ca occurs in the rat fetus after thyroparathyrodectomy or the injection of antibovine parathyroid hormone (24,25).…”
Section: Discussionmentioning
confidence: 99%
“…Direct evidence that the fetal parathyroid glands are capable of secretion was provided by Scothorne (1964). Additional studies were reported more recently (Graham and Scothorne, 1971;Smith et al, 1972). However, the first demonstration that fetal parathyroid glands can influence fetal calcemia was performed by Pic et al (1965).…”
Section: Introductionmentioning
confidence: 95%