The ontogenies of endometrial and myometrial leptin and adiponectin receptors in pregnant rats: Their putative impact on uterine contractility

Schaffer, Annamária; Ducza, Eszter; Bódi, Nikolett; Bagyánszki, Mária; Szalai, Zita; Mirdamadi, Mohsen; Barna, Tamara; Szűcs, Kálmán Ferenc; Gáspár, Róbert

doi:10.1016/j.lfs.2022.120465

Cited by 6 publications

(7 citation statements)

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“…Conversely leptin did not show any effect on PGF 2α -induced uterine contractions on the last day of the gestation period. The effects of these adipokines in SD rats are in harmony with our earlier experiments [ 13 , 14 ]. The HFHSD-induced relaxing effect of adipokines further confirms obesity-induced uterine dystocia.…”

Section: Discussionsupporting

confidence: 89%

“…In the case of oxytocin-induced contractions, HFHSD ceased the relaxing and contracting effects of kisspeptin and leptin, respectively. The contracting effect of leptin in SD uteri was not detected in our previous study, but in that measurement the contractions were elicited by KCl [ 14 ]. Earlier it was reported that leptin did not modify spontaneous and oxytocin-induced contractions on either human or rat myometria [ 28 ], although another experiment proved its relaxing effect on the human uterus [ 27 ].…”

Section: Discussionmentioning

confidence: 86%

“…The uterine action of leptin has been clarified in human and rat studies [ 27 , 28 ]. Currently, the ontogeny of leptin and adiponectin in uterine action has been revealed during pregnancy in rats, proving their relaxing effects, although neither of them had an effect on uterine contractions at term [ 14 ]. Adiponectin is considered as an anti-inflammatory adipokine balancing the obesity-induced oxidative processes [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…Since both the increase in receptor expression and plasma level can enhance the effect of a given adipokine, these results suggest that the leptin pathway has the strongest, while the adiponectin pathway has the weakest (or neutral), influence on HFHSD-induced modifications in uterine contractions. Our previous studies revealed that both leptin and kisspeptin have a relaxing effect on last-day pregnant uteri [ 13 , 14 ], therefore we anticipated that these alterations should reduce uterine contractions.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the enlarged adipocyte undergoes continuous remodeling from hyperplasia to hypertrophy, therefore the synthesis of these adipokines is also altered in obesity [ 11 , 12 ]. The ontogeny of kisspeptin, leptin and adiponectin receptors through the gestation period and the effects of adipokines on uterine contractions have been proved in rats [ 13 , 14 ]. However, no data are available about their effects on uterine contraction in obese pregnant rats.…”

Section: Introductionmentioning

confidence: 99%

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High Fat High Sucrose Diet Modifies Uterine Contractility and Cervical Resistance in Pregnant Rats: The Roles of Sex Hormones, Adipokines and Cytokines

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Hajagos-Tóth

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Background: In obesity, the adipose tissue becomes a very significant endocrine organ producing different factors called adipokines, such as leptin, adiponectin and kisspeptin; however, no data are available about their actions on uterine contraction in obese pregnant rats. Our aim was to study the impact of obesity on pregnant uterine contraction in a rat model. Methods: Obesity was induced by the consumption of a high fat high sucrose diet (HFHSD) for 9 weeks, including pregnancy. Glucose tolerance, sex hormone, cytokine and adipokine levels were measured. Uterine contractions and cervical resistance, as well as their responses to adipokines, were tested along with the expressions of their uterine receptors. Results: HFHSD increased body weight, and altered glucose tolerance and fat composition. The uterine leptin and kisspeptin pathway affect increased. The levels of proinflammatory cytokines were reduced, while the plasma level of progesterone was increased, resulting in weaker uterine contractions, and improving the uterine relaxing effects of adipokines. HFHSD reduced cervical resistance, but the core effect of adipokines is difficult to determine. Conclusions: Obesity in pregnant rats reduces uterine contractility and cytokine-induced inflammatory processes, and therefore obese pregnant rat methods are partially applicable for modelling human processes.

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Section: Discussionsupporting

confidence: 89%