The ontogeny of inhibition and excitation in the gerbil lateral superior olive

Sanes, DH; Rubel, EW

doi:10.1523/jneurosci.08-02-00682.1988

Cited by 186 publications

(178 citation statements)

References 85 publications

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“…The basic response properties in response to single, binaural stimuli of the neurons we studied were consistent with previous reports on the gerbil LSO (Sanes and Rubel, 1988). The best frequencies among the neurons in our sample ranged from 1.0 to 39.0 kHz, and the majority of the neurons responded throughout the stimulus duration with a primary-like temporal response pattern, although we also recorded from 3 onset cells.…”

Section: Resultssupporting

confidence: 90%

Dynamic changes in level influence spatial coding in the lateral superior olive

Park¹,

Brand

Koch

et al. 2008

Hearing Research

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It is well established that the responses of binaural auditory neurons can adapt and change dramatically depending on the nature of a preceding sound. Examples of how the effects of ensuing stimuli play a functional role in auditory processing include motion sensitivity and precedence-like effects. To date, these types of effects have been documented at the level of the midbrain and above. Little is known about sensitivity to ensuing stimuli below in the superior olivary nuclei where binaural response properties are first established. Here we report on single cell responses in the gerbil lateral superior olive, the initial site where sensitivity to interaural level differences is established. In contrast to our expectations we found a robust sensitivity to ensuing stimuli. The majority of the cells we tested (86%), showed substantial suppression and/or enhancement to a designated target stimulus, depending on the nature of a preceding stimulus. Hence, sensitivity to ensuing stimuli is already established at the first synaptic station of binaural processing.

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Section: Resultssupporting

confidence: 90%

Dynamic changes in level influence spatial coding in the lateral superior olive

Park¹,

Brand

Koch

et al. 2008

Hearing Research

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“…Auditory cortical IRFs were far more heterogeneous and irregular than those described for the auditory nerve, which shows the opposite trend of bandwidth changes with age (25). Moreover, the auditory nerve and brainstem mature very early in the course of development compared with what we observed in the cortex (25)(26)(27)(28)(29).…”

Section: Discussioncontrasting

confidence: 43%

Development of spectral and temporal response selectivity in the auditory cortex

Chang

Bao²,

Imaizumi³

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

150

160

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The mechanisms by which hearing selectivity is elaborated and refined in early development are very incompletely determined. In this study, we documented contributions of progressively maturing inhibitory influences on the refinement of spectral and temporal response properties in the primary auditory cortex. Inhibitory receptive fields (IRFs) of infant rat auditory cortical neurons were spectrally far broader and had extended over far longer duration than did those of adults. The selective refinement of IRFs was delayed relative to that of excitatory receptive fields by an Ϸ2-week period that corresponded to the critical period for plasticity. Local application of a GABA A receptor antagonist revealed that intracortical inhibition contributes to this progressive receptive field maturation for response selectivity in frequency. Conversely, it had no effect on the duration of IRFs or successive-signal cortical response recovery times. The importance of exposure to patterned acoustic inputs was suggested when both spectral and temporal IRF maturation were disrupted in rat pups reared in continuous, moderate-intensity noise. They were subsequently renormalized when animals were returned to standard housing conditions as adults.

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“…Gerbil (Meriones unguiculatus) pups at P8-21 were used for these studies. The age range represents the time during which auditory functional properties are known to mature (53)(54)(55)(56)(57)(58). All protocols were reviewed and approved by the New York University Institutional Animal Care and Use Committee.…”

Section: Methodsmentioning

confidence: 99%

Developmental hearing loss eliminates long-term potentiation in the auditory cortex

Kotak

Breithaupt

Sanes³

2007

Proc. Natl. Acad. Sci. U.S.A.

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Severe hearing loss during early development is associated with deficits in speech and language acquisition. Although functional studies have shown a deafness-induced alteration of synaptic strength, it is not known whether long-term synaptic plasticity depends on auditory experience. In this study, sensorineural hearing loss (SNHL) was induced surgically in developing gerbils at postnatal day 10, and excitatory synaptic plasticity was examined subsequently in a brain slice preparation that preserves the thalamorecipient auditory cortex. Extracellular stimuli were applied at layer 6 (L6), whereas evoked excitatory synaptic potentials (EPSPs) were recorded from L5 neurons by using a whole-cell current clamp configuration. In control neurons, the conditioning stimulation of L6 significantly altered EPSP amplitude for at least 1 h. Approximately half of neurons displayed long-term potentiation (LTP), whereas the other half displayed long-term depression (LTD). In contrast, SNHL neurons displayed only LTD after the conditioning stimulation of L6. Finally, the vast majority of neurons recorded from control prehearing animals (postnatal days 9 -11) displayed LTD after L6 stimulation. Thus, normal auditory experience may be essential for the maturation of synaptic plasticity mechanisms.deafness ͉ long-term depression S evere hearing loss is known to affect auditory processing in humans. This loss includes impairments of signal detection in noise or in a multiple source environment, and disruption of intensity discrimination, frequency discrimination, and temporal resolution (1-4). Even transient bouts of conductive hearing loss can disrupt auditory processing, and months or years may be required for normal perception to resolve (5, 6). Because severe hearing loss during development is implicated in the deficient acquisition of auditory perceptual skills and language, which presumably require learning, we have examined whether synaptic plasticity is also affected.At a structural level, hearing impairments can lead to neuron death or atrophy and alter process outgrowth (7). Furthermore, direct examination of neuron function in brain slice preparations from deaf animals has revealed significant physiological changes to intrinsic and synaptic properties. In both the inferior colliculus and auditory cortex (ACx), early sensorineural hearing loss (SNHL) alters the balance of excitatory and inhibitory synaptic strength (8-10). A similar disruption in synaptic physiology and certain intrinsic properties also occurs in the auditory brainstem of the congenitally deaf mutant mouse (11,12).Both long-term potentiation (LTP) and depression (LTD) have been characterized in a series of studies on the rat ACx (13-18). For example, an NMDA receptor-mediated LTP in the ACx can be induced by stimulation of afferents innervating the ACx via the white matter (13), whereas thalamo-and corticocortical synapse activation can induce LTD (16). These cellular mechanisms may serve as a substrate for use-dependent alteration of coding properties in...

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The ontogeny of inhibition and excitation in the gerbil lateral superior olive

Cited by 186 publications

References 85 publications

Dynamic changes in level influence spatial coding in the lateral superior olive

Dynamic changes in level influence spatial coding in the lateral superior olive

Development of spectral and temporal response selectivity in the auditory cortex

Developmental hearing loss eliminates long-term potentiation in the auditory cortex

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